Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| PD173074 | 184A1 | -4.4776 | 0.8593 | -5.0370 | -4.8249 | -5.0956 | 1.9590 | 0.3079 | 0.3593 | 8.3583 |
| Temsirolimus | SUM225CWN | -3.8761 | 0.8593 | -6.0851 | -6.0846 | NaN | 0.3143 | 0.0000 | 0.1682 | 4.9875 |
| XRP44X | HCC2185 | -3.8761 | 0.8594 | -6.1671 | -5.9741 | -6.2836 | 3.9985 | 0.3949 | 0.3949 | 6.7505 |
| XRP44X | ZR75B | -3.8761 | 0.8594 | -6.0381 | -5.4220 | -5.9202 | 1.7480 | 0.4581 | 0.4582 | 6.8995 |
| Z-Leu-Leu-Norvalinal | SUM1315MO2 | -4.1759 | 0.8595 | -5.9989 | -5.9987 | -6.8638 | 0.9127 | 0.0000 | 0.0212 | 5.7823 |
| Doxorubicin | MDA-MB-468 | -6.2596 | 0.8596 | -6.9948 | -6.9180 | -7.1414 | 1.9500 | 0.1211 | 0.1824 | 7.4972 |
| NU6102 | BT-549 | -4.1759 | 0.8598 | -4.5400 | -4.5400 | -4.5428 | 1.2360 | 0.0000 | 0.2619 | 7.9008 |
| NU6102 | HCC38 | -4.1759 | 0.8599 | -4.9315 | -4.9316 | -5.0834 | 1.3550 | 0.0000 | 0.0864 | 6.8630 |
| Bortezomib | MDA-MB-361 | -3.7773 | 0.8601 | -4.3489 | -3.8887 | -4.8480 | 0.6586 | 0.3148 | 0.5610 | 8.4566 |
| Docetaxel | HCC2185 | -5.0000 | 0.8601 | -8.4610 | -5.0000 | -8.5299 | 2.8345 | 0.6559 | 0.6559 | 7.0951 |
| PD173074 | ZR-75-1 | -4.4776 | 0.8601 | -4.6280 | -4.6280 | -4.9060 | 1.5490 | 0.0000 | 0.3647 | 7.8117 |
| AG1478 | HCC1419 | -3.7773 | 0.8604 | -5.5218 | -4.4282 | -5.8626 | 2.5230 | 0.3929 | 0.4050 | 7.2197 |
| 17-AAG | HCC1187 | -4.0000 | 0.8605 | -5.4455 | -5.2561 | -5.6429 | 2.1765 | 0.2686 | 0.2708 | 6.9055 |
| Nutlin 3a | HCC1937 | -4.1759 | 0.8610 | -4.5521 | -4.4253 | -4.5974 | 2.8750 | 0.2258 | 0.3795 | 8.2752 |
| IKK16 | HCC1187 | -4.1759 | 0.8613 | -5.2939 | -5.2932 | -5.3874 | 3.5105 | 0.0024 | 0.0026 | 6.5265 |
| Trametinib | SUM229PE | -4.7773 | 0.8615 | -8.0593 | -6.8511 | -8.2068 | 0.6907 | 0.3234 | 0.3271 | 5.4947 |
| Vinorelbine | MCF 10F | -4.3335 | 0.8616 | -7.8480 | -7.6827 | -7.8817 | 3.1090 | 0.3278 | 0.3278 | 5.3146 |
| Temsirolimus | MCF 10A | -3.8761 | 0.8618 | -6.1221 | -6.1219 | NaN | 0.3292 | 0.0000 | 0.1542 | 5.0694 |
| GSK461364 | 600MPE | -4.4776 | 0.8618 | -4.8362 | -4.8362 | -4.8631 | 4.0000 | 0.0000 | 0.0355 | 7.9370 |
| TCS 2312 | MDA-MB-175-VII | -4.4776 | 0.8619 | -5.6106 | -4.4776 | -5.9556 | 0.9789 | 0.3623 | 0.5772 | 7.8359 |
| CGC-11047 | HCC1187 | -2.3010 | 0.8621 | -2.8646 | -2.8646 | -3.4233 | 2.6940 | 0.0000 | 0.0607 | 7.3689 |
| Nutlin 3a | SUM1315MO2 | -4.1759 | 0.8622 | -4.4465 | -4.4465 | -4.7517 | 1.6350 | 0.0000 | 0.2503 | 8.0487 |
| Afatinib | HCC1937 | -4.1759 | 0.8622 | -5.4529 | -5.4531 | -6.0631 | 0.9720 | 0.0000 | 0.0542 | 6.1316 |
| GSK1838705A | MDA-MB-231 | -4.1759 | 0.8626 | -5.3939 | -5.3805 | -5.4071 | 3.9890 | 0.0575 | 0.0575 | 7.2303 |
| Temsirolimus | MDA-MB-361 | -3.8761 | 0.8626 | -5.0426 | -5.0426 | -6.5629 | 0.4436 | 0.0000 | 0.2351 | 6.2507 |