Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Gemcitabine | ZR75B | -3.8416 | 0.7019 | -7.6686 | -3.8416 | -7.4014 | 3.9460 | 0.7177 | 0.7177 | 7.4982 |
| Bortezomib | AU565 | -3.7773 | 0.9948 | -7.6683 | -7.6678 | -7.7217 | 3.7605 | 0.0035 | 0.0035 | 2.9784 |
| Geldanamycin | SUM185PE | -4.0000 | 0.9622 | -7.6670 | -7.5819 | -7.8045 | 3.2290 | 0.2000 | 0.2000 | 4.6139 |
| Omipalisib | BT-474 | -4.4776 | 0.9827 | -7.6646 | -7.5992 | -8.3285 | 0.7338 | 0.0520 | 0.0564 | 4.2655 |
| Ispinesib | BT-20 | -4.4776 | 0.9307 | -7.6586 | -7.5079 | -7.8227 | 2.0120 | 0.2162 | 0.2162 | 5.0491 |
| Docetaxel | BT-483 | -5.0000 | 0.7596 | -7.6580 | -5.0000 | -7.5839 | 1.6960 | 0.7542 | 0.7542 | 8.0907 |
| Omipalisib | MDA-MB-453 | -4.4776 | 0.9438 | -7.6551 | -7.6413 | -8.4034 | 0.5528 | 0.0102 | 0.0332 | 3.9920 |
| Vinorelbine | HCC1187 | -4.3335 | 0.8827 | -7.6535 | -7.6178 | -7.7931 | 3.9930 | 0.1407 | 0.1407 | 4.5048 |
| Topotecan | BT-549 | -3.9626 | 0.9871 | -7.6526 | -7.6260 | -7.7001 | 2.6710 | 0.0748 | 0.0748 | 3.5874 |
| Taxol | HCC202 | -4.4776 | 0.8745 | -7.6526 | -4.4776 | -8.0799 | 0.7451 | 0.5002 | 0.5024 | 6.4149 |
| GSK923295 | HCC1954 | -4.4776 | 0.9367 | -7.6491 | -7.5936 | -7.7045 | 2.7265 | 0.1315 | 0.1315 | 4.6766 |
| GSK461364 | SK-BR-3 | -4.4776 | 0.8909 | -7.6476 | -7.5380 | -7.6994 | 3.9790 | 0.3129 | 0.3129 | 5.8281 |
| Gemcitabine | ZR-75-1 | -3.8416 | 0.9262 | -7.6441 | -3.8416 | -7.4682 | 2.3580 | 0.6182 | 0.6182 | 6.7463 |
| Omipalisib | ZR-75-1 | -4.4776 | 0.9752 | -7.6386 | -7.4713 | -8.0848 | 0.9233 | 0.1479 | 0.1496 | 4.7729 |
| MG-132 | 184B5 | -4.1759 | 0.9692 | -7.6379 | -7.5323 | -7.8110 | 1.3330 | 0.1381 | 0.1381 | 4.3089 |
| Ispinesib | HCC1954 | -4.4776 | 0.9862 | -7.6346 | -7.6273 | -7.6930 | 3.8165 | 0.0307 | 0.0307 | 4.0712 |
| Geldanamycin | T47D | -4.0000 | 0.9769 | -7.6310 | -7.4618 | -7.8048 | 3.1990 | 0.3566 | 0.3566 | 5.2630 |
| Trametinib | ZR75B | -4.7773 | 0.7284 | -7.6263 | -4.7773 | -4.7773 | 0.5066 | 0.8157 | 0.8221 | 8.3485 |
| GSK923295 | SUM52PE | -4.4776 | 0.9727 | -7.6256 | -7.5380 | -7.6586 | 3.9030 | 0.2728 | 0.2728 | 5.4051 |
| Bortezomib | HCC1187 | -3.7773 | 0.9896 | -7.6223 | -7.6220 | -7.8008 | 3.0070 | 0.0000 | 0.0000 | 3.0973 |
| GSK923295 | AU565 | -4.4776 | 0.9743 | -7.6196 | -7.5660 | -7.7122 | 2.9380 | 0.1295 | 0.1295 | 4.6744 |
| Torkinib | MCF 10A | -4.3010 | 0.9476 | -7.6170 | -7.2991 | -7.5499 | 0.5381 | 0.1629 | 0.1764 | 4.6086 |
| Taxol | SUM185PE | -4.4776 | 0.9568 | -7.6056 | -4.4776 | -7.6561 | 2.0200 | 0.5571 | 0.5571 | 7.2149 |
| Ispinesib | HCC1806 | -4.4776 | 0.9677 | -7.6056 | -7.5647 | -7.6317 | 3.4310 | 0.1391 | 0.1391 | 4.7889 |
| GSK923295 | SUM1315MO2 | -4.4776 | 0.9754 | -7.6036 | -7.0706 | -7.6782 | 2.7190 | 0.4822 | 0.4822 | 6.3987 |