Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Fascaplysin | UACC-893 | -4.4776 | 0.9920 | -6.4296 | -6.4285 | -6.5724 | 3.9560 | 0.0046 | 0.0046 | 5.6547 |
| Imatinib | MDA-MB-453 | -3.2480 | 0.9413 | -4.7725 | -4.7724 | -5.0029 | 1.5870 | 0.0000 | 0.0046 | 5.9356 |
| Carboplatin | HCC1806 | -2.8697 | 0.9862 | -4.6327 | -4.6326 | -4.8368 | 1.3335 | 0.0000 | 0.0047 | 6.0367 |
| Sunitinib | MDA-MB-134-VI | -3.7773 | 0.9658 | -4.9123 | -4.9109 | -5.0599 | 3.6070 | 0.0046 | 0.0047 | 6.6684 |
| Fascaplysin | SUM225CWN | -4.4776 | 0.9848 | -6.9386 | -6.9375 | -7.2700 | 1.8930 | 0.0038 | 0.0048 | 4.9975 |
| IKK16 | BT-20 | -4.1759 | 0.9599 | -5.3159 | -5.3147 | -5.4623 | 3.4685 | 0.0046 | 0.0048 | 6.9221 |
| Sunitinib | BT-483 | -3.7773 | 0.9482 | -4.8363 | -4.8355 | -5.0244 | 3.9990 | 0.0049 | 0.0049 | 6.5248 |
| NSC 663284 | BT-20 | -3.7773 | 0.9674 | -5.2248 | -5.2249 | -5.5083 | 1.6885 | 0.0000 | 0.0049 | 6.2020 |
| CGC-11144 | MCF12A | -3.1500 | 0.9901 | -6.0770 | -6.0770 | -6.2451 | 0.7874 | 0.0000 | 0.0049 | 4.2375 |
| IKK16 | HCC1395 | -4.1759 | 0.9762 | -5.5859 | -5.5862 | -5.8341 | 1.6360 | 0.0000 | 0.0049 | 6.5435 |
| NSC 663284 | MCF 10A | -3.7773 | 0.9765 | -5.6693 | -5.6674 | -5.7118 | 2.5110 | 0.0049 | 0.0049 | 5.7116 |
| CGC-11144 | HCC1937 | -3.1500 | 0.9900 | -6.6190 | -6.6173 | -6.7567 | 2.0810 | 0.0050 | 0.0050 | 6.5606 |
| (Z)-4-Hydroxytamoxifen | SUM185PE | -3.7773 | 0.9923 | -4.9263 | -4.9251 | -5.0872 | 4.0000 | 0.0050 | 0.0050 | 7.0261 |
| NSC 663284 | HCC1419 | -3.7773 | 0.9496 | -5.3373 | -5.3377 | -5.7659 | 1.4760 | 0.0000 | 0.0050 | 5.9643 |
| Imatinib | HCC1419 | -3.2480 | 0.9854 | -4.4645 | -4.4631 | -4.6953 | 3.8055 | 0.0051 | 0.0051 | 6.7375 |
| Trichostatin A | SK-BR-3 | -2.3010 | 0.9858 | -5.1370 | -5.1345 | -5.2881 | 1.6250 | 0.0051 | 0.0052 | 4.2956 |
| Imatinib | SUM149PT | -3.2480 | 0.9675 | -4.6360 | -4.6354 | -4.6881 | 3.9880 | 0.0052 | 0.0052 | 6.6917 |
| Fascaplysin | HCC1806 | -4.4776 | 0.9717 | -6.5146 | -6.5131 | -6.5995 | 2.3115 | 0.0053 | 0.0053 | 5.5217 |
| 5-FU | MCF12A | -1.7167 | 0.9774 | -4.6097 | -4.6098 | -4.8465 | 0.7850 | 0.0000 | 0.0053 | 4.4501 |
| Fascaplysin | 600MPE | -4.4776 | 0.9843 | -6.4026 | -6.4010 | -6.5333 | 3.9995 | 0.0053 | 0.0053 | 5.6846 |
| NSC 663284 | SUM149PT | -3.7773 | 0.9808 | -5.6728 | -5.6714 | -5.7412 | 2.9745 | 0.0053 | 0.0053 | 5.9823 |
| IKK16 | SUM225CWN | -4.1759 | 0.9778 | -5.3949 | -5.3935 | -5.5350 | 3.4750 | 0.0054 | 0.0054 | 6.7101 |
| NSC 663284 | UACC-812 | -3.7773 | 0.9777 | -5.2943 | -5.2946 | -5.6379 | 1.5900 | 0.0000 | 0.0054 | 6.1324 |
| Imatinib | T47D | -3.2480 | 0.9692 | -4.6025 | -4.6027 | -4.8049 | 1.7295 | 0.0000 | 0.0054 | 6.3271 |
| Fascaplysin | HCC1428 | -4.4776 | 0.9933 | -7.2466 | -7.2446 | -7.4391 | 2.6515 | 0.0054 | 0.0054 | 4.4905 |