Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Docetaxel | 184B5 | -5.0000 | 0.8431 | -8.6610 | -5.0000 | -8.3663 | 2.1670 | 0.6800 | 0.6800 | 7.7232 |
| 5-DFUR | 184B5 | -2.3010 | 0.8541 | -2.7726 | -2.7726 | -3.6487 | 0.3219 | 0.0000 | 0.4135 | 7.0046 |
| Nutlin 3a | 184B5 | -4.1759 | 0.9183 | -4.9725 | -4.9726 | -5.2634 | 1.6990 | 0.0000 | 0.1206 | 7.1532 |
| Ispinesib | 184B5 | -4.4776 | 0.9283 | -5.7096 | -5.7086 | -6.0282 | 1.8341 | 0.0029 | 0.0888 | 6.5769 |
| Ixabepilone | 184B5 | -4.4045 | 0.9619 | -6.4745 | -6.4747 | -7.0501 | 0.6073 | 0.0000 | 0.0553 | 5.4131 |
| Cisplatin | 184B5 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | 184B5 | -4.0000 | 0.9840 | -7.5290 | -7.4996 | -7.6292 | 3.9990 | 0.1172 | 0.1172 | 4.1652 |
| Ibandronate | 184B5 | -2.8239 | 0.9723 | -3.5250 | -3.5251 | -3.6415 | 2.4920 | 0.0000 | 0.0176 | 7.4721 |
| Tozasertib | 184B5 | -4.0000 | 0.9641 | -5.3720 | -5.3719 | -5.7560 | 0.7204 | 0.0000 | 0.0932 | 6.4426 |
| MG-132 | 184B5 | -4.1759 | 0.9692 | -7.6379 | -7.5323 | -7.8110 | 1.3330 | 0.1381 | 0.1381 | 4.3089 |
| Carboplatin | 184B5 | -2.8697 | 0.9700 | -4.9237 | -4.9237 | -5.2930 | 1.0740 | 0.0000 | 0.0062 | 5.6519 |
| GSK923295 | 184B5 | -4.4776 | 0.7603 | -4.9213 | -4.9213 | -5.6113 | 1.2381 | 0.0000 | 0.2486 | 7.3003 |
| Imatinib | 184B5 | -3.2480 | 0.9858 | -4.5110 | -4.5095 | -4.6356 | 2.8725 | 0.0039 | 0.0042 | 6.5564 |
| Gefitinib | 184B5 | -4.4776 | 0.9725 | -7.3466 | -6.6212 | -7.4590 | 0.9009 | 0.3889 | 0.3905 | 6.2609 |
| CGC-11047 | 184B5 | -2.3010 | 0.8980 | -3.2456 | -3.2456 | -3.3430 | 2.7040 | 0.0000 | 0.0028 | 7.9739 |
| CGC-11144 | 184B5 | -3.1500 | 0.9953 | -5.4775 | -5.4718 | -5.6580 | 1.9745 | 0.0145 | 0.0146 | 5.2227 |
| Lestaurtinib | 184B5 | -4.4776 | 0.9783 | -6.2066 | -6.2065 | -6.5206 | 0.9772 | 0.0000 | 0.0200 | 5.8920 |
| Erlotinib | 184B5 | -4.1759 | 0.9338 | -6.4349 | -5.4362 | -6.3665 | 0.8467 | 0.4286 | 0.4395 | 6.8308 |
| Everolimus | 184B5 | -4.1759 | 0.7009 | -5.0564 | -5.0563 | NaN | 0.2937 | 0.0000 | 0.3554 | 6.4059 |
| LBH589 | 184B5 | -4.4776 | 0.9694 | -6.6326 | -6.4825 | -7.0115 | 0.6120 | 0.0953 | 0.1368 | 5.8331 |
| GSK1070916 | 184B5 | -4.4776 | 0.9613 | -5.3762 | -5.3761 | -6.1627 | 0.5692 | 0.0000 | 0.2357 | 7.0319 |
| IKK16 | 184B5 | -4.1759 | 0.9731 | -5.5839 | -5.5837 | -5.7947 | 1.9490 | 0.0000 | 0.0018 | 6.7393 |
| Sunitinib | 184B5 | -3.7773 | 0.9902 | -5.1233 | -5.1228 | -5.2864 | 2.5950 | 0.0021 | 0.0045 | 6.6070 |
| Bortezomib | 184B5 | -3.7773 | 0.9844 | -7.5418 | -7.4975 | -7.7046 | 2.0090 | 0.0924 | 0.0924 | 3.6326 |
| Gemcitabine | 184B5 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |