Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | BT-549 | -4.3010 | 0.9734 | -7.1280 | -7.1278 | -7.5059 | 0.5019 | 0.0000 | 0.0367 | 4.4051 |
| Olomoucine II | BT-549 | -3.8761 | 0.9558 | -5.6701 | -5.6198 | -5.7029 | 1.5420 | 0.0813 | 0.0829 | 6.3945 |
| Baicalein | BT-549 | -3.7773 | 0.9586 | -4.6665 | -4.6045 | -4.6742 | 1.8410 | 0.1153 | 0.1353 | 7.3849 |
| Docetaxel | BT-549 | -5.0000 | 0.9751 | -8.5540 | -8.3753 | -8.5191 | 1.7370 | 0.2542 | 0.2542 | 4.8575 |
| Doxorubicin | CAMA-1 | -6.2596 | 0.9750 | -6.5136 | -6.5136 | -6.9555 | 1.5700 | 0.0000 | 0.2853 | 8.0312 |
| XRP44X | CAMA-1 | -3.8761 | 0.9426 | -6.1091 | -5.9382 | -6.1744 | 3.4615 | 0.3672 | 0.3672 | 6.4770 |
| CGC-11047 | CAMA-1 | -2.3010 | 0.9190 | -2.7147 | -2.7148 | -2.8581 | 2.9430 | 0.0000 | 0.0571 | 7.0804 |
| Tozasertib | CAMA-1 | -4.0000 | 0.9263 | -4.2342 | -4.2342 | -4.2323 | 3.2830 | 0.0001 | 0.1456 | 7.9614 |
| MG-132 | CAMA-1 | -4.1759 | 0.8250 | -6.5769 | -6.5282 | -6.7204 | 3.1330 | 0.1484 | 0.1484 | 5.4384 |
| MG-132 | CAMA-1 | -4.1759 | 0.9825 | -6.6329 | -6.6194 | -6.7944 | 3.1845 | 0.0409 | 0.0409 | 4.9827 |
| Temsirolimus | CAMA-1 | -3.8761 | 0.9061 | -6.1471 | -6.1472 | -7.3708 | 0.3358 | 0.0000 | 0.1473 | 5.1614 |
| (Z)-4-Hydroxytamoxifen | CAMA-1 | -3.7773 | 0.8957 | -4.3451 | -4.3451 | -4.4415 | 3.3760 | 0.0000 | 0.0120 | 7.4837 |
| Ibandronate | CAMA-1 | -2.8239 | 0.9353 | -3.6538 | -3.6125 | -3.8697 | 2.7190 | 0.1001 | 0.1246 | 7.4016 |
| Nutlin 3a | CAMA-1 | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.0974 |
| GSK1059615 | CAMA-1 | -3.8761 | 0.9730 | -5.5201 | -5.3972 | -5.8029 | 1.1190 | 0.1362 | 0.1485 | 6.5521 |
| CPT-11 | CAMA-1 | -4.0696 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.8674 |
| Imatinib | CAMA-1 | -3.2480 | 0.9889 | -4.5860 | -4.5847 | -4.7328 | 3.1970 | 0.0056 | 0.0059 | 6.5864 |
| IKK16 | CAMA-1 | -4.1759 | 0.9341 | -5.4409 | -5.4409 | -5.5702 | 2.7570 | 0.0000 | 0.0003 | 6.4513 |
| Etoposide | CAMA-1 | -3.4776 | 0.9467 | -5.0031 | -4.7789 | -5.4490 | 1.0133 | 0.1952 | 0.2616 | 6.6985 |
| Sunitinib | CAMA-1 | -3.7773 | 0.9798 | -4.9863 | -4.9856 | -5.0970 | 4.0000 | 0.0030 | 0.0031 | 6.6815 |
| Pevonedistat | CAMA-1 | -4.1759 | 0.9062 | -7.1969 | -6.7206 | -7.3820 | 1.5490 | 0.4241 | 0.4260 | 6.0696 |
| Sigma A6730 | CAMA-1 | -4.1759 | 0.8885 | -4.9314 | -4.9314 | -5.2633 | 1.1930 | 0.0000 | 0.1115 | 6.9279 |
| Gemcitabine | CAMA-1 | -3.8416 | 0.8152 | -7.2376 | -3.8416 | -6.5058 | 0.5254 | 0.6609 | 0.6664 | 7.2283 |
| Taxol | CAMA-1 | -4.4776 | 0.9765 | -7.9036 | -7.7533 | -7.9616 | 3.9990 | 0.3749 | 0.3749 | 5.6568 |
| Bosutinib | CAMA-1 | -4.0000 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.5865 |