Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| NSC 663284 | AU565 | -3.7773 | 0.9878 | -5.6613 | -5.6574 | -5.8312 | 1.8550 | 0.0085 | 0.0088 | 5.8452 |
| Doxorubicin | AU565 | -6.2596 | 0.9064 | -7.2888 | -7.2496 | -7.4293 | 1.8740 | 0.0680 | 0.0814 | 7.0531 |
| 5-FU | AU565 | -1.7167 | 0.9613 | -4.4707 | -4.0266 | -5.2077 | 0.7024 | 0.1849 | 0.2294 | 5.7445 |
| Triciribine | AU565 | -4.4776 | 0.9816 | -7.3716 | -7.3323 | -7.6135 | 0.7532 | 0.0324 | 0.0389 | 4.5358 |
| Pevonedistat | AU565 | -4.1759 | 0.9700 | -6.7649 | -6.6571 | -6.8026 | 2.3630 | 0.2215 | 0.2215 | 5.6749 |
| Trichostatin A | AU565 | -2.3010 | 0.9924 | -5.4325 | -5.4300 | -5.5016 | 2.8975 | 0.0083 | 0.0083 | 4.0767 |
| Gemcitabine | AU565 | -3.8416 | 0.9938 | -7.7556 | -7.6986 | -7.8877 | 2.5020 | 0.1406 | 0.1406 | 3.7074 |
| PD173074 | AU565 | -4.4776 | 0.9380 | -5.1283 | -5.0852 | -5.1382 | 3.9970 | 0.1635 | 0.1656 | 8.0550 |
| MG-132 | AU565 | -4.1759 | 0.9201 | -6.6274 | -6.6094 | -6.7017 | 3.6365 | 0.0712 | 0.0712 | 5.2001 |
| AG1478 | AU565 | -3.7773 | 0.9725 | -5.2063 | -5.1690 | -5.2744 | 2.3610 | 0.0909 | 0.0913 | 7.2424 |
| Vinorelbine | AU565 | -4.3335 | 0.9787 | -8.2355 | -8.2178 | -8.2931 | 3.9965 | 0.0760 | 0.0760 | 3.4210 |
| Trametinib | AU565 | -4.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 9.1204 |
| 5-DFUR | AU565 | -2.3010 | 0.8667 | -5.3030 | -4.3049 | -5.2191 | 0.5622 | 0.3626 | 0.3754 | 6.0160 |
| LBH589 | AU565 | -4.4776 | 0.9834 | -6.9676 | -6.9639 | -7.0587 | 2.7590 | 0.0109 | 0.0109 | 4.9219 |
| Taxol | AU565 | -4.4776 | 0.9817 | -8.0346 | -8.0127 | -8.1165 | 3.4830 | 0.0920 | 0.0920 | 3.9264 |
| MG-132 | AU565 | -4.1759 | 0.9861 | -6.8929 | -6.8879 | -7.0390 | 2.1840 | 0.0128 | 0.0128 | 4.5793 |
| Erlotinib | AU565 | -4.1759 | 0.9595 | -5.0055 | -4.9647 | -5.1425 | 1.3900 | 0.0614 | 0.1230 | 7.4829 |
| Afatinib | AU565 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Bortezomib | AU565 | -3.7773 | 0.9948 | -7.6683 | -7.6678 | -7.7217 | 3.7605 | 0.0035 | 0.0035 | 2.9784 |
| Docetaxel | AU565 | -5.0000 | 0.9874 | -8.2250 | -8.1981 | -8.3478 | 2.8860 | 0.1007 | 0.1007 | 4.2729 |
| Temsirolimus | AU565 | -3.8761 | 0.8897 | -6.2321 | -6.2320 | NaN | 0.2802 | 0.0000 | 0.1795 | 4.9226 |
| Topotecan | AU565 | -3.9626 | 0.9944 | -7.7496 | -7.7184 | -7.7936 | 2.4000 | 0.0780 | 0.0780 | 3.5241 |
| Everolimus | AU565 | -4.1759 | 0.8377 | -5.6639 | -5.6636 | NaN | 0.3874 | 0.0000 | 0.2096 | 6.1953 |
| CGC-11144 | AU565 | -3.1500 | 0.9771 | -6.1935 | -6.1874 | -6.3518 | 1.3880 | 0.0097 | 0.0102 | 4.1883 |
| TCS 2312 | AU565 | -4.4776 | 0.9759 | -6.4866 | -6.4847 | -6.5654 | 3.9990 | 0.0109 | 0.0109 | 5.8846 |