LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist A in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20361)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_7
 Etoposide 72 0.3042 0.0190 0.4408 0.30097 0.0071 1.3586 0.9944
1.11022302463e-16
MCF10A-GM_1
 Vorinostat 72 1.1221 0.0197 0.2903 1.23808 -0.0618 1.1857 0.9886
1.11022302463e-16
MCF10A-GM_8
 Vorinostat 72 1.4114 0.0224 0.2573 1.60992 -0.0799 1.1262 0.9912
1.11022302463e-16
MCF10A-GM_9
 Etoposide 72 0.3309 0.0254 0.4307 0.33219 -0.0027 1.3774 0.9906
1.11022302463e-16
MCF10A-GM_5
 Vorinostat 72 1.3313 0.0338 0.2592 1.36448 -0.0168 1.3398 0.9902
1.11022302463e-16
MCF10A-GM_6
 Etoposide 72 0.2631 0.0338 0.4508 0.25611 0.0190 1.4355 0.9907
1.11022302463e-16
MCF10A-GM_4
 Etoposide 72 0.2572 0.0358 0.4719 0.25672 0.0011 1.2747 0.9927
1.11022302463e-16
MCF10A-GM_1
 Palbociclib 72 0.3755 0.0386 0.3583 0.32427 0.0472 0.6762 0.9684
9.82769421398e-13
MCF10A-GM_9
 Vorinostat 72 1.5617 0.0388 0.2396 1.73350 -0.0679 1.2213 0.9929
1.11022302463e-16
MCF10A-GM_5
 Etoposide 72 0.2715 0.0390 0.4546 0.26956 0.0047 1.3382 0.9912
1.11022302463e-16
MCF10A-GM_4
 Vorinostat 72 1.2988 0.0419 0.2685 1.40992 -0.0509 1.1821 0.9889
1.11022302463e-16
MCF10A-GM_6
 Vorinostat 72 1.3632 0.0467 0.2659 1.48443 -0.0521 1.1625 0.9892
1.11022302463e-16
MCF10A-GM_1
 Trametinib 72 0.0037 0.0635 0.6324 0.00299 0.1133 1.2768 0.9809
1.11022302463e-16
MCF10A-GM_1
 Neratinib 72 0.1969 0.0642 0.3725 0.18049 0.0506 1.2255 0.8983
1.20580212482e-11
MCF10A-GM_2
 Neratinib 72 0.2054 0.0672 0.3563 0.18651 0.0602 1.3299 0.9097
3.26805249529e-12
MCF10A-GM_9
 Trametinib 72 0.0038 0.0688 0.6336 0.00308 0.1142 1.3043 0.9848
1.11022302463e-16
MCF10A-GM_3
 Neratinib 72 0.2022 0.0710 0.3721 0.18743 0.0439 1.2090 0.8942
1.85039761291e-11
MCF10A-GM_7
 Trametinib 72 0.0039 0.0719 0.6340 0.00325 0.1062 1.3464 0.9839
1.11022302463e-16
MCF10A-GM_3
 Trametinib 72 0.0032 0.0891 0.6444 0.00254 0.1236 1.1674 0.9882
1.11022302463e-16
MCF10A-GM_2
 Trametinib 72 0.0031 0.0932 0.6454 0.00247 0.1261 1.2703 0.9864
1.11022302463e-16
MCF10A-GM_4
 Trametinib 72 0.0035 0.0966 0.6434 0.00287 0.1094 1.2248 0.9799
1.11022302463e-16
MCF10A-GM_3
 Palbociclib 72 0.6883 0.0974 0.3032 0.58742 0.0550 0.7356 0.9773
6.93889390391e-14
MCF10A-GM_5
 Trametinib 72 0.0037 0.1008 0.6277 0.00294 0.1274 1.3150 0.9855
1.11022302463e-16
MCF10A-GM_8
 Trametinib 72 0.0040 0.1027 0.6263 0.00331 0.1110 1.2895 0.9906
1.11022302463e-16
MCF10A-GM_4
 Palbociclib 72 1.0359 0.1030 0.2711 1.08666 -0.0193 0.7905 0.9851
2.44249065418e-15