LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist A in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20361)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_4
 Neratinib 72 0.3333 0.1249 0.2789 0.25439 0.1756 1.6016 0.8850
4.64310812021e-11
MCF10A-GM_5
 Neratinib 72 0.3531 0.1178 0.2790 0.30699 0.0908 1.4312 0.9264
3.44724249146e-13
MCF10A-GM_3
 Vorinostat 72 1.1270 0.0140 0.2901 1.24865 -0.0667 1.2227 0.9848
1.11022302463e-16
MCF10A-GM_1
 Vorinostat 72 1.1221 0.0197 0.2903 1.23808 -0.0618 1.1857 0.9886
1.11022302463e-16
MCF10A-GM_2
 Vorinostat 72 1.1217 0.0167 0.2934 1.30060 -0.0891 1.1078 0.9862
1.11022302463e-16
MCF10A-GM_3
 Palbociclib 72 0.6883 0.0974 0.3032 0.58742 0.0550 0.7356 0.9773
6.93889390391e-14
MCF10A-GM_2
 Palbociclib 72 0.5075 0.1059 0.3396 0.44124 0.0438 0.6549 0.9544
1.88525861589e-11
MCF10A-GM_2
 Neratinib 72 0.2054 0.0672 0.3563 0.18651 0.0602 1.3299 0.9097
3.26805249529e-12
MCF10A-GM_1
 Palbociclib 72 0.3755 0.0386 0.3583 0.32427 0.0472 0.6762 0.9684
9.82769421398e-13
MCF10A-GM_3
 Neratinib 72 0.2022 0.0710 0.3721 0.18743 0.0439 1.2090 0.8942
1.85039761291e-11
MCF10A-GM_1
 Neratinib 72 0.1969 0.0642 0.3725 0.18049 0.0506 1.2255 0.8983
1.20580212482e-11
MCF10A-GM_9
 Dasatinib 72 0.4467 -0.1284 0.4150 0.83179 -0.2801 0.7155 0.9765
1.11022302463e-16
MCF10A-GM_7
 Dasatinib 72 0.3822 -0.1253 0.4260 0.60000 -0.2136 0.7889 0.9676
1.11022302463e-16
MCF10A-GM_9
 Etoposide 72 0.3309 0.0254 0.4307 0.33219 -0.0027 1.3774 0.9906
1.11022302463e-16
MCF10A-GM_8
 Etoposide 72 0.3062 0.0111 0.4362 0.30305 0.0072 1.4070 0.9958
1.11022302463e-16
MCF10A-GM_4
 Dasatinib 72 0.3273 -0.1411 0.4382 0.51788 -0.2003 0.7342 0.9688
1.11022302463e-16
MCF10A-GM_8
 Dasatinib 72 0.3362 -0.1510 0.4405 0.46460 -0.1541 0.8309 0.9643
1.11022302463e-16
MCF10A-GM_7
 Etoposide 72 0.3042 0.0190 0.4408 0.30097 0.0071 1.3586 0.9944
1.11022302463e-16
MCF10A-GM_5
 Dasatinib 72 0.3227 -0.1921 0.4426 0.48669 -0.1945 0.7999 0.9614
3.33066907388e-16
MCF10A-GM_6
 Etoposide 72 0.2631 0.0338 0.4508 0.25611 0.0190 1.4355 0.9907
1.11022302463e-16
MCF10A-GM_6
 Dasatinib 72 0.3435 -0.1607 0.4528 0.66326 -0.2814 0.6786 0.9728
1.11022302463e-16
MCF10A-GM_5
 Etoposide 72 0.2715 0.0390 0.4546 0.26956 0.0047 1.3382 0.9912
1.11022302463e-16
MCF10A-GM_2
 Etoposide 72 0.2479 0.0064 0.4665 0.24608 0.0050 1.3936 0.9932
1.11022302463e-16
MCF10A-GM_1
 Dasatinib 72 0.2837 -0.1309 0.4667 0.43854 -0.2021 0.7795 0.9729
1.11022302463e-16
MCF10A-GM_2
 Dasatinib 72 0.3007 -0.1486 0.4680 0.61942 -0.3062 0.6611 0.9635
1.11022302463e-16