LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alpelisib | 180614_BG_02 | 12312 | 0.0199 | 56 | 190 | 6 | 5 | Alpelisib | 0.997999808 | treatment | 72 | 1 | MCF10A-GM_2 | 246 | 0.0196 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00041 | 0.8528 |
| Trametinib | 180622_BG_6 | 17616 | 0.0230 | 87 | 320 | 10 | 4 | Trametinib | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_2 | 407 | 0.0226 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00354 | 0.9451 |
| Dasatinib | 180614_BG_02 | 15269 | 0.0196 | 54 | 246 | 11 | 16 | Dasatinib | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_2 | 300 | 0.0193 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00073 | 0.9488 |
| Vorinostat | 180614_BG_02 | 12198 | 0.0186 | 31 | 196 | 7 | 9 | Vorinostat | 0.316033316 | treatment | 72 | 1 | MCF10A-GM_2 | 227 | 0.0183 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00173 | 0.8488 |
| Dasatinib | 180622_BG_6 | 1778 | 0.1612 | 65 | 232 | 12 | 3 | Dasatinib | 3.193598006 | treatment | 72 | 2 | MCF10A-GM_2 | 297 | 0.1431 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.11701 | 0.1800 |
| Dasatinib | 180622_BG_6 | 841 | 0.4573 | 130 | 314 | 7 | 11 | Dasatinib | 9.98 | treatment | 72 | 2 | MCF10A-GM_2 | 444 | 0.3455 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.31940 | 0.0023 |
| Palbociclib | 180622_BG_6 | 3314 | 0.0437 | 96 | 53 | 6 | 15 | Palbociclib | 3.160329361 | treatment | 72 | 2 | MCF10A-GM_2 | 149 | 0.0430 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.01690 | 0.3515 |
| Etoposide | 180614_BG_02 | 4012 | 0.0355 | 46 | 98 | 10 | 6 | Etoposide | 0.316033316 | treatment | 72 | 1 | MCF10A-GM_2 | 144 | 0.0346 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01465 | 0.4242 |
| Taxol | 180614_BG_02 | 17049 | 0.0180 | 35 | 273 | 12 | 5 | Paclitaxel | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_2 | 308 | 0.0177 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00225 | 0.9999 |
| Taxol | 180614_BG_02 | 679 | 0.6935 | 153 | 424 | 11 | 7 | Paclitaxel | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_2 | 577 | 0.4594 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.43940 | -0.0613 |
| Palbociclib | 180622_BG_6 | 1487 | 0.0795 | 98 | 28 | 9 | 10 | Palbociclib | 10.01326667 | treatment | 72 | 2 | MCF10A-GM_2 | 126 | 0.0781 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.05199 | 0.1349 |
| Trametinib | 180614_BG_02 | 12915 | 0.0120 | 18 | 137 | 10 | 19 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_2 | 155 | 0.0119 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00814 | 0.8737 |
| Alpelisib | 180614_BG_02 | 16954 | 0.0137 | 33 | 199 | 13 | 15 | Alpelisib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_2 | 232 | 0.0135 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00650 | 0.9972 |
| Palbociclib | 180622_BG_6 | 5421 | 0.0292 | 120 | 42 | 9 | 15 | Palbociclib | 0.997999609 | treatment | 72 | 2 | MCF10A-GM_2 | 162 | 0.0290 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.00289 | 0.5045 |
| Trametinib | 180622_BG_6 | 14842 | 0.0175 | 74 | 187 | 10 | 19 | Trametinib | 0.000998 | treatment | 72 | 2 | MCF10A-GM_2 | 261 | 0.0173 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00884 | 0.8738 |
| Palbociclib | 180622_BG_6 | 12146 | 0.0216 | 102 | 162 | 8 | 6 | Palbociclib | 0.099799997 | treatment | 72 | 2 | MCF10A-GM_2 | 264 | 0.0213 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00485 | 0.7937 |
| Etoposide | 180614_BG_02 | 10483 | 0.0164 | 22 | 150 | 9 | 13 | Etoposide | 0.099799999 | treatment | 72 | 1 | MCF10A-GM_2 | 172 | 0.0161 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00385 | 0.7842 |
| Palbociclib | 180622_BG_6 | 17105 | 0.0184 | 74 | 242 | 9 | 16 | Palbociclib | 0.031603333 | treatment | 72 | 2 | MCF10A-GM_2 | 316 | 0.0181 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00799 | 0.9327 |
| Trametinib | 180614_BG_02 | 16908 | 0.0187 | 50 | 267 | 10 | 4 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_2 | 317 | 0.0184 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00159 | 0.9960 |
| Vorinostat | 180614_BG_02 | 16639 | 0.0162 | 11 | 259 | 10 | 10 | Vorinostat | 0.099799999 | treatment | 72 | 1 | MCF10A-GM_2 | 270 | 0.0160 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00403 | 0.9885 |
| Alpelisib | 180614_BG_02 | 17099 | 0.0205 | 34 | 317 | 13 | 13 | Alpelisib | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_2 | 351 | 0.0201 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00012 | 1.0012 |
| Dasatinib | 180622_BG_6 | 6772 | 0.0457 | 80 | 233 | 10 | 20 | Dasatinib | 0.316033316 | treatment | 72 | 2 | MCF10A-GM_2 | 313 | 0.0442 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.01805 | 0.5793 |
| Palbociclib | 180622_BG_6 | 5819 | 0.0292 | 111 | 62 | 4 | 21 | Palbociclib | 0.332666627 | treatment | 72 | 2 | MCF10A-GM_2 | 173 | 0.0289 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.00275 | 0.5279 |
| Dasatinib | 180614_BG_02 | 16726 | 0.0193 | 62 | 262 | 12 | 9 | Dasatinib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_2 | 324 | 0.0190 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00099 | 0.9909 |
| Palbociclib | 180622_BG_6 | 20385 | 0.0339 | 137 | 559 | 13 | 8 | Palbociclib | 0.003326667 | treatment | 72 | 2 | MCF10A-GM_2 | 696 | 0.0330 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.00689 | 1.0080 |