Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1500 | Etoposide | Topo II | Chemotherapy | 1.4287 | -0.0766 | 0.2499 | -0.0148 | 1.3319 | 1.7871 | 0.95725 |
| BT-20 | Etoposide | Topo II | Chemotherapy | 0.30148 | -0.3834 | 0.4591 | 0.1362 | 1.2176 | 0.48057 | 0.99643 |
| MDA-MB-134-VI | Etoposide | Topo II | Chemotherapy | 0.086844 | -0.5248 | 0.6635 | 0.0687 | 0.6849 | 0.28885 | 0.9792 |
| HCC1954 | Etoposide | Topo II | Chemotherapy | 0.17121 | -0.2651 | 0.5015 | 0.2166 | 0.9804 | 0.2578 | 0.98586 |
| HCC1937 | Etoposide | Topo II | Chemotherapy | 0.35445 | -0.1182 | 0.3932 | 0.1412 | 0.8265 | 0.49943 | 0.98817 |
| MDA-MB-453 | Etoposide | Topo II | Chemotherapy | 0.38265 | -0.0601 | 0.3658 | 0.0418 | 1.5864 | 0.41689 | 0.99692 |
| PDX1328 | Etoposide | Topo II | Chemotherapy | 0.80493 | -0.2805 | 0.3502 | 0.0172 | 1.4732 | 1.1571 | 0.98432 |
| T47D | Etoposide | Topo II | Chemotherapy | 0.041662 | -0.1861 | 0.6661 | 0.0533 | 1.1976 | 0.051932 | 0.98563 |
| HCC1143 | Etoposide | Topo II | Chemotherapy | 0.46267 | -0.1664 | 0.3837 | 0.1279 | 1.8259 | 0.55287 | 0.99758 |
| SK-BR-3 | Etoposide | Topo II | Chemotherapy | 0.39826 | -0.3169 | 0.4040 | 0.1186 | 1.5701 | 0.532 | 0.99524 |
| Hs 578T | Etoposide | Topo II | Chemotherapy | 0.41322 | -0.1361 | 0.3770 | 0.1666 | 2.0332 | 0.46109 | 0.99901 |
| HCC1419 | Etoposide | Topo II | Chemotherapy | 0.73579 | 0.0317 | 0.3201 | 0.0034 | 1.8770 | 0.70309 | 0.96133 |
| PDX1258 | Etoposide | Topo II | Chemotherapy | 0.31701 | -0.1807 | 0.3942 | 0.1360 | 1.0906 | 0.41876 | 0.99346 |
| HCC1806 | Etoposide | Topo II | Chemotherapy | 0.096233 | -0.5629 | 0.6490 | 0.2019 | 0.9767 | 0.2057 | 0.99535 |
| CAL-85-1 | Etoposide | Topo II | Chemotherapy | 0.41623 | -0.2411 | 0.4065 | 0.1218 | 1.3731 | 0.57431 | 0.99814 |
| SUM149PT | Etoposide | Topo II | Chemotherapy | 0.12658 | -0.1961 | 0.5269 | 0.2243 | 1.3281 | 0.1575 | 0.99818 |
| HCC70 | Etoposide | Topo II | Chemotherapy | 0.36498 | -0.1518 | 0.4535 | 0.0513 | 2.1004 | 0.41879 | 0.96872 |
| MCF 10A | Etoposide | Topo II | Chemotherapy | 0.28398 | -0.0699 | 0.4155 | 0.0691 | 1.3527 | 0.31593 | 0.99713 |
| CAL-51 | Etoposide | Topo II | Chemotherapy | 0.24029 | -0.2097 | 0.4669 | 0.0707 | 1.1885 | 0.32971 | 0.99772 |
| MDA-MB-231 | Etoposide | Topo II | Chemotherapy | 0.7036 | 0.1203 | 0.2978 | 0.0095 | 1.5558 | 0.62323 | 0.99162 |
| HCC38 | Etoposide | Topo II | Chemotherapy | 0.33384 | -0.4242 | 0.4494 | 0.1891 | 1.4384 | 0.50554 | 0.99763 |
| SUM159PT | Etoposide | Topo II | Chemotherapy | 0.41904 | -0.1489 | 0.3736 | 0.1389 | 1.7468 | 0.47824 | 0.99862 |
| SUM1315MO2 | Etoposide | Topo II | Chemotherapy | 0.29244 | 0.0416 | 0.3833 | 0.1087 | 0.7536 | 0.26458 | 0.97369 |
| HME1 | Etoposide | Topo II | Chemotherapy | 0.13797 | -0.3838 | 0.5421 | 0.1754 | 1.3297 | 0.19469 | 0.98888 |
| HCC1428 | Etoposide | Topo II | Chemotherapy | 0.21399 | -0.0320 | 0.4009 | 0.0511 | 1.7833 | 0.20625 | 0.98346 |