Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | Cabozantinib | VEGFR2/MET | RTK | Inf | 0.6624 | 0.0628 | -0.0003 | 4.9832 | 4.0443 | 0.74358 |
| MDA-MB-468 | Cabozantinib | VEGFR2/MET | RTK | 8.9681 | 0.4233 | 0.0441 | 0.0115 | 1.7711 | 16.6732 | 0.9812 |
| MDA-MB-134-VI | Cabozantinib | VEGFR2/MET | RTK | 10.9194 | 0.6362 | -0.0167 | -0.0063 | 5.0000 | 12.725 | 0.88168 |
| MDA-MB-453 | Cabozantinib | VEGFR2/MET | RTK | 9.0899 | 0.4645 | -0.0045 | 0.0208 | 4.5355 | 6.5788 | 0.94161 |
| HCC38 | Cabozantinib | VEGFR2/MET | RTK | 8.2108 | 0.3009 | 0.0376 | 0.0168 | 4.3352 | 8.1748 | 0.98657 |
| PDXHCI002 | Cabozantinib | VEGFR2/MET | RTK | 7.2097 | 0.2341 | 0.0443 | 0.0248 | 1.8969 | 12.8614 | 0.98302 |
| SUM149PT | Cabozantinib | VEGFR2/MET | RTK | 5.7589 | 0.2895 | 0.0383 | 0.0198 | 4.7896 | 4.9143 | 0.99303 |
| HCC1419 | Cabozantinib | VEGFR2/MET | RTK | 10.7779 | 0.6224 | -0.0111 | -0.0016 | 5.0000 | 12.9768 | 0.90031 |
| MCF 10A | Cabozantinib | VEGFR2/MET | RTK | 25.9104 | 0.8434 | -0.0114 | 0.0040 | 4.9998 | 11.7694 | 0.81226 |
| SK-BR-3 | Cabozantinib | VEGFR2/MET | RTK | 9.7073 | 0.4422 | 0.0013 | 0.0011 | 5.0000 | 12.0523 | 0.95604 |
| CAL-120 | Cabozantinib | VEGFR2/MET | RTK | 7.3417 | 0.2574 | 0.0848 | 0.0071 | 1.8478 | 13.277 | 0.98262 |
| MDA-MB-157 | Cabozantinib | VEGFR2/MET | RTK | 2.7778 | 0.1490 | 0.2101 | 0.0326 | 0.5335 | 21.7804 | 0.97157 |
| HCC1954 | Cabozantinib | VEGFR2/MET | RTK | 10.9106 | 0.6390 | -0.0135 | -0.0074 | 5.0000 | 13.0234 | 0.87916 |
| CAL-51 | Cabozantinib | VEGFR2/MET | RTK | 7.7705 | 0.3063 | 0.0598 | 0.0166 | 1.8325 | 14.1514 | 0.98918 |
| HCC1500 | Cabozantinib | VEGFR2/MET | RTK | 4.6683 | 0.1837 | 0.0599 | 0.0128 | 4.9992 | 4.2912 | 0.97044 |
| MDA-MB-231 | Cabozantinib | VEGFR2/MET | RTK | 4.8325 | 0.0749 | 0.1413 | 0.0336 | 1.2384 | 11.7338 | 0.95871 |
| BT-549 | Cabozantinib | VEGFR2/MET | RTK | 10.1855 | 0.5329 | 0.0124 | 0.0096 | 5.0000 | 12.5665 | 0.95054 |
| Hs 578T | Cabozantinib | VEGFR2/MET | RTK | 6.3728 | 0.2155 | 0.1335 | 0.0452 | 1.3885 | 14.0588 | 0.89112 |
| MCF7 | Cabozantinib | VEGFR2/MET | RTK | 4.8819 | -0.0993 | 0.1069 | 0.0302 | 1.8080 | 8.9638 | 0.99698 |
| HCC1395 | Cabozantinib | VEGFR2/MET | RTK | 5.5518 | 0.1138 | 0.0722 | 0.0131 | 1.6522 | 9.2961 | 0.98977 |
| HCC1937 | Cabozantinib | VEGFR2/MET | RTK | 14.4371 | 0.7602 | 0.0053 | 0.0067 | 4.9892 | 11.0339 | 0.95897 |
| PDX1258 | Cabozantinib | VEGFR2/MET | RTK | 8.2309 | 0.2796 | 0.0244 | 0.0160 | 3.8695 | 8.9263 | 0.98303 |
| PDX1328 | Cabozantinib | VEGFR2/MET | RTK | 1.8826 | -0.1622 | 0.2366 | 0.0206 | 0.7816 | 7.6768 | 0.95877 |
| SUM1315MO2 | Cabozantinib | VEGFR2/MET | RTK | 4.5316 | 0.1095 | 0.1089 | 0.0163 | 1.1058 | 12.2361 | 0.99069 |
| HME1 | Cabozantinib | VEGFR2/MET | RTK | 3.2402 | -0.1052 | 0.1020 | 0.0260 | 2.6885 | 3.6278 | 0.98973 |