Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
Hs 578T Pictilisib
pan PI3K
PI3K/mTOR
1.1555
 0.0345 0.3109 0.0488 0.4397
14.0561
0.97858
HCC1954 Ipatasertib
AKT
PI3K/mTOR
1.4342
 0.2509 0.2145 0.0288 0.9249
0.80694
0.98539
HCC1954 Alpelisib
PI3Ka
PI3K/mTOR
1.2292
 -0.3408 0.2652 0.1073 0.8509
4.4679
0.99224
HCC1954 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0070107
 -0.3632 0.9490 0.3748 1.0954
0.010784
0.99379
HCC1954 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9607 -0.0374 -0.0050 0.0000
Inf
-1.0282
HCC1954 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0096629
 -0.3280 0.5536 0.1704 0.7380
0.018218
0.98125
HCC1954 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.3263 0.6531 0.1358 0.0000
Inf
0.52018
HCC1954 INK-128
mTORC1/2
PI3K/mTOR
0.014251
 -0.0830 0.5651 0.1455 1.3479
0.013876
0.98856
HCC1954 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.8349 -0.0093 -0.0064 1.3800
7.2097
0.65841
HCC1954 Buparlisib
pan PI3K
PI3K/mTOR
0.52073
 -0.4576 0.4002 0.1883 1.6194
0.7982
0.9975
HCC1954 Pictilisib
pan PI3K
PI3K/mTOR
0.94449
 -0.2272 0.3087 0.1077 0.8502
2.3595
0.9976
HCC70 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.9348 -0.0227 0.0035 0.0000
Inf
0.040075
HCC70 INK-128
mTORC1/2
PI3K/mTOR
0.0048011
 -0.1620 0.7024 0.0912 1.1840
0.0050026
0.97794
HCC70 Everolimus
mTOR1
PI3K/mTOR
0.24351
 0.3727 0.4764 0.0448 0.1135
51.0339
0.79604
HCC70 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0058452
 -0.5550 0.6451 0.1234 0.5307
0.026938
0.94991
HCC70 TGX221
PI3Kb
PI3K/mTOR
0.092754
 0.0049 0.4729 0.0591 0.8818
0.076452
0.9787
HCC70 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.15092
 -0.6846 0.5796 0.1546 0.7043
0.64661
0.98584
HCC70 Alpelisib
PI3Ka
PI3K/mTOR
4.4987
 0.0981 0.1182 0.0196 1.0448
12.8744
0.95143
HCC70 Ipatasertib
AKT
PI3K/mTOR
0.1397
 -0.2624 0.4974 0.0860 0.8534
0.21677
0.98567
Hs 578T Buparlisib
pan PI3K
PI3K/mTOR
0.68631
 -0.3434 0.3760 0.1520 1.4596
1.0562
0.9918
Hs 578T PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.9143 0.0252 0.0005 2.0096
0.1778
0.76824
Hs 578T INK-128
mTORC1/2
PI3K/mTOR
0.0090588
 -0.0708 0.6226 0.1010 1.2366
0.0087974
0.98428
Hs 578T Everolimus
mTOR1
PI3K/mTOR
0.0056053
 0.4204 0.5273 0.0278 0.4084
2.87e-05
0.64462
Hs 578T Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0070774
 -0.2174 0.5683 0.1373 0.7608
0.010409
0.98427
Hs 578T TGX221
PI3Kb
PI3K/mTOR
34.4921
 0.7094 0.0668 0.0103 0.5623
243.351
0.9333