Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MCF 10A Volasertib
PLK
Cell cycle
0.022128
 -0.0887 0.4466 0.1711 3.5358
0.023168
0.99997
HCC1806 Abemaciclib
CDK4/6
Cell cycle
0.59453
 -0.4440 0.3921 0.1035 0.6190
3.5069
0.96621
HCC38 Palbociclib
CDK4/6
Cell cycle
0.059804
 0.1474 0.3722 0.0411 1.0985
0.037879
0.98636
HCC38 Volasertib
PLK
Cell cycle
0.0081934
 -0.2598 0.6001 0.1943 3.2088
0.0091367
0.99678
HCC38 Dinaciclib
pan CDK
Cell cycle
0.012678
 -0.4422 0.6326 0.2241 4.1199
0.014763
0.99821
HCC1806 Volasertib
PLK
Cell cycle
0.0027998
 -0.1323 0.7262 0.2950 5.0000
0.0029495
0.99776
MCF 10A Palbociclib
CDK4/6
Cell cycle
1.9503
 0.4544 0.1883 -0.0047 0.6492
0.23713
0.99244
MCF7 Palbociclib
CDK4/6
Cell cycle
0.074952
 0.2542 0.3461 0.0139 1.0473
0.035667
0.99237
Hs 578T Abemaciclib
CDK4/6
Cell cycle
0.077629
 -0.5825 0.6343 0.1966 0.4160
1.0889
0.95772
Hs 578T Palbociclib
CDK4/6
Cell cycle
0.15611
 0.3049 0.3195 0.0363 0.7223
0.037735
0.98196
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944
Hs 578T Volasertib
PLK
Cell cycle
0.0025675
 -0.3123 0.8198 0.3337 3.0081
0.0029864
0.9987
Hs 578T Dinaciclib
pan CDK
Cell cycle
0.0089363
 -0.2388 0.6160 0.2121 4.9934
0.0096082
0.99916
HCC1806 Dinaciclib
pan CDK
Cell cycle
0.013395
 -0.4585 0.6439 0.3114 3.4710
0.016174
0.99891
MCF 10A Abemaciclib
CDK4/6
Cell cycle
0.34027
 0.1513 0.3811 -0.0012 0.5714
0.28176
0.99756
SK-BR-3 Dinaciclib
pan CDK
Cell cycle
0.0068129
 -0.6209 0.8362 0.3009 3.4320
0.008573
0.99807
BT-20 Abemaciclib
CDK4/6
Cell cycle
0.061268
 -0.2160 0.5694 0.0435 0.4177
0.17789
0.93347
MCF7 Volasertib
PLK
Cell cycle
0.0028671
 -0.0338 0.6070 0.1245 4.2176
0.002824
0.99423
MDA-MB-231 Palbociclib
CDK4/6
Cell cycle
0.11065
 0.2066 0.3469 0.0101 0.7428
0.05699
0.98815
MCF7 AZD7762
CHK1/2
Cell cycle
0.04144
 -0.1856 0.5977 0.1318 0.8993
0.048851
0.95892
MCF7 Dinaciclib
pan CDK
Cell cycle
0.0083068
 -0.2493 0.6441 0.1256 3.5461
0.009348
0.9995
HCC1806 AZD7762
CHK1/2
Cell cycle
0.016629
 -0.4822 0.8897 0.3907 1.6771
0.023183
0.99277
MCF 10A AZD7762
CHK1/2
Cell cycle
1.8064
 -0.1800 0.2246 0.0802 0.8472
6.6065
0.99793
HCC70 Dinaciclib
pan CDK
Cell cycle
0.01286
 -0.9093 0.8338 0.3254 5.0000
0.015807
0.9991
HCC70 Volasertib
PLK
Cell cycle
0.0065224
 -0.2049 0.6421 0.1395 3.2698
0.0072379
0.9841