Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-120 Taxol
Chemo
Chemotherapy
0.0028769
 -0.1987 0.7463 0.3104 2.6390
0.0032354
0.97877
MDA-MB-468 Etoposide
Topo II
Chemotherapy
0.48754
 -0.5132 0.4291 0.1644 1.8475
0.69756
0.99577
MCF 10A Topotecan
Topo I
Chemotherapy
0.009871
 -0.2000 0.7653 0.1401 1.1478
0.01069
0.95965
MDA-MB-468 Cisplatin
Chemo
Chemotherapy
1.2638
 -0.2866 0.2872 0.0977 1.4057
1.9559
0.99503
MCF 10A Taxol
Chemo
Chemotherapy
0.0026843
 -0.1256 0.7023 0.2576 1.8234
0.003018
0.9967
MDA-MB-468 Topotecan
Topo I
Chemotherapy
0.015779
 -0.6577 1.0692 0.4464 2.1036
0.023029
0.99528
CAL-120 Topotecan
Topo I
Chemotherapy
0.007493
 -0.3364 0.9130 0.2556 1.1649
0.010414
0.97973
CAL-120 Doxorubicin
Chemo
Chemotherapy
0.009438
 -0.2475 0.6969 0.1356 1.3775
0.011488
0.99278
CAL-120 Cisplatin
Chemo
Chemotherapy
2.9328
 0.1876 0.1824 0.0229 0.9231
4.0426
0.98856
PDX1328 Topotecan
Topo I
Chemotherapy
0.0059222
 -0.9128 1.0720 0.1509 0.4616
0.063175
0.94441
PDX1328 Etoposide
Topo II
Chemotherapy
0.80493
 -0.2805 0.3502 0.0172 1.4732
1.1571
0.98432
MDA-MB-468 Doxorubicin
Chemo
Chemotherapy
0.0054214
 -0.3392 0.9121 0.3191 2.4137
0.0067542
0.99424
MDA-MB-231 Etoposide
Topo II
Chemotherapy
0.7036
 0.1203 0.2978 0.0095 1.5558
0.62323
0.99162
MDA-MB-231 Taxol
Chemo
Chemotherapy
0.0023185
 -0.1204 0.7021 0.2576 1.1720
0.0026636
0.96432
PDX1328 Cisplatin
Chemo
Chemotherapy
0.77968
 -0.4217 0.3154 0.0259 1.3251
1.2886
0.9879
PDX1328 Doxorubicin
Chemo
Chemotherapy
0.013267
 -0.7789 0.8023 0.1468 1.4934
0.021574
0.96338
MDA-MB-231 Topotecan
Topo I
Chemotherapy
0.029665
 -0.3241 0.7044 0.0793 0.6645
0.059258
0.94327
MCF 10A Cisplatin
Chemo
Chemotherapy
4.2937
 0.3794 0.0952 0.0149 2.1287
2.4561
0.99519
MDA-MB-468 Taxol
Chemo
Chemotherapy
0.001354
 -0.5218 1.0076 0.5243 1.2795
0.0023644
0.95471
CAL-120 Etoposide
Topo II
Chemotherapy
0.47956
 -0.1663 0.3810 0.0949 1.2763
0.62593
0.99712
HCC1954 Cisplatin
Chemo
Chemotherapy
1.2467
 -0.0741 0.2747 0.0807 1.1281
1.7233
0.97383
MCF 10A Doxorubicin
Chemo
Chemotherapy
0.010766
 -0.3242 0.6549 0.1054 1.4229
0.012388
0.96407
PDX1328 Taxol
Chemo
Chemotherapy
0.002983
 -0.5332 0.9047 0.1888 3.1886
0.0036802
0.98401
HCC1954 Doxorubicin
Chemo
Chemotherapy
0.0071835
 -0.3378 0.7296 0.2544 1.4590
0.0086345
0.96869
MDA-MB-231 Doxorubicin
Chemo
Chemotherapy
0.0050428
 -0.4864 0.8179 0.2092 1.0560
0.0077676
0.95921