Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1806 Etoposide
Topo II
Chemotherapy
0.096233
 -0.5629 0.6490 0.2019 0.9767
0.2057
0.99535
SK-BR-3 Etoposide
Topo II
Chemotherapy
0.39826
 -0.3169 0.4040 0.1186 1.5701
0.532
0.99524
PDX1328 Topotecan
Topo I
Chemotherapy
0.0059222
 -0.9128 1.0720 0.1509 0.4616
0.063175
0.94441
HCC1419 Doxorubicin
Chemo
Chemotherapy
0.025082
 -0.4663 0.5904 0.0473 0.5199
0.10425
0.94593
SK-BR-3 Topotecan
Topo I
Chemotherapy
0.016549
 -0.2711 0.7941 0.1919 1.9350
0.01923
0.98214
SK-BR-3 Taxol
Chemo
Chemotherapy
0.0019068
 -0.3401 0.8905 0.3665 2.3888
0.0023578
0.96349
PDX1328 Doxorubicin
Chemo
Chemotherapy
0.013267
 -0.7789 0.8023 0.1468 1.4934
0.021574
0.96338
SK-BR-3 Doxorubicin
Chemo
Chemotherapy
0.0067336
 -0.6156 0.9421 0.3142 1.5278
0.010801
0.99572
SK-BR-3 Cisplatin
Chemo
Chemotherapy
5.1075
 0.2490 0.0978 0.0114 1.4151
5.7965
0.99044
Hs 578T Etoposide
Topo II
Chemotherapy
0.41322
 -0.1361 0.3770 0.1666 2.0332
0.46109
0.99901
PDX1328 Etoposide
Topo II
Chemotherapy
0.80493
 -0.2805 0.3502 0.0172 1.4732
1.1571
0.98432
Hs 578T Topotecan
Topo I
Chemotherapy
0.0049855
 -0.4488 1.0175 0.4717 1.1814
0.0076404
0.9429
HCC1806 Taxol
Chemo
Chemotherapy
0.0014225
 -0.2113 0.8398 0.3493 2.1569
0.0016621
0.96243
PDX1258 Etoposide
Topo II
Chemotherapy
0.31701
 -0.1807 0.3942 0.1360 1.0906
0.41876
0.99346
Hs 578T Taxol
Chemo
Chemotherapy
0.0010154
 -0.3752 0.9535 0.4788 1.2811
0.0015458
0.95438
MDA-MB-453 Taxol
Chemo
Chemotherapy
0.002374
 0.0356 0.6674 0.1683 1.2620
0.0023576
0.81734
HCC1937 Taxol
Chemo
Chemotherapy
0.0024514
 0.0104 0.6576 0.2104 2.2541
0.0024561
0.99541
MDA-MB-453 Topotecan
Topo I
Chemotherapy
0.0066897
 -0.5289 0.9258 0.1604 1.0131
0.010358
0.92364
Hs 578T Doxorubicin
Chemo
Chemotherapy
0.0041078
 -0.3466 0.8007 0.2450 1.2269
0.0052684
0.96807
PDX1328 Cisplatin
Chemo
Chemotherapy
0.77968
 -0.4217 0.3154 0.0259 1.3251
1.2886
0.9879
Hs 578T Cisplatin
Chemo
Chemotherapy
1.5413
 0.0125 0.2347 0.0930 1.4392
1.6968
0.99339
MDA-MB-453 Doxorubicin
Chemo
Chemotherapy
0.0058313
 -0.3476 0.7915 0.1805 1.7510
0.0071438
0.98132
MDA-MB-453 Etoposide
Topo II
Chemotherapy
0.38265
 -0.0601 0.3658 0.0418 1.5864
0.41689
0.99692
HCC1937 Topotecan
Topo I
Chemotherapy
0.0155
 -0.4282 0.8369 0.2949 0.6712
0.03544
0.94323
PDX1258 Taxol
Chemo
Chemotherapy
0.0021522
 -0.0818 0.6797 0.2357 1.2501
0.0022935
0.98829