Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-134-VI Volasertib
PLK
Cell cycle
0.0027209
 -0.6274 1.0260 0.2671 5.0000
0.0032225
0.99553
HCC1500 ABT-737
Bcl2/XL
Misc
0.0085142
 -0.7359 1.1288 0.3716 0.9283
0.022222
0.99554
HCC1395 Ceritinib
ALK
RTK
1.6025
 -0.6268 0.2363 0.0809 1.8434
2.6534
0.99554
BT-549 Ceritinib
ALK
RTK
2.961
 -0.2284 0.1416 0.0526 1.8781
4.216
0.99556
PDX1258 Tivantinib
MET
RTK
0.39607
 -0.2089 0.3834 0.1084 1.2903
0.54289
0.9956
HCC1806 Vorinostat
HDAC
Misc
1.1276
 0.0178 0.2397 0.0491 1.3263
1.2167
0.99564
MCF7 Dasatinib
BCR/ABL
MAPK/nRTK
0.069398
 0.1574 0.4829 0.0400 1.6265
0.055227
0.99565
T47D Tivantinib
MET
RTK
0.3478
 -0.1544 0.3824 0.1267 3.7033
0.37139
0.99567
Hs 578T Vorinostat
HDAC
Misc
0.90288
 -0.1689 0.2728 0.1049 2.2431
1.0225
0.99568
CAL-85-1 Cediranib
VEGFR/cKIT
RTK
2.4003
 -0.2379 0.1869 0.0514 1.1002
6.5151
0.99569
HCC70 Abemaciclib
CDK4/6
Cell cycle
1.885
 -0.8264 0.2315 0.0832 2.5102
2.8439
0.99569
SK-BR-3 Tivantinib
MET
RTK
0.27263
 -0.3523 0.4830 0.2060 2.4177
0.34098
0.99571
SK-BR-3 Doxorubicin
Chemo
Chemotherapy
0.0067336
 -0.6156 0.9421 0.3142 1.5278
0.010801
0.99572
HCC38 Ceritinib
ALK
RTK
1.8283
 -0.4039 0.2184 0.0883 2.6153
2.323
0.99573
HCC1428 Tivantinib
MET
RTK
0.2516
 0.0341 0.3664 0.1106 2.2041
0.23715
0.99573
MDA-MB-468 Ceritinib
ALK
RTK
0.76749
 -0.7415 0.4050 0.1730 1.6622
1.3833
0.99574
SUM149PT Taxol
Chemo
Chemotherapy
0.0015927
 -0.2583 0.8405 0.3816 3.1045
0.0017914
0.99574
BT-20 INK-128
mTORC1/2
PI3K/mTOR
0.012881
 -0.0045 0.5675 0.1137 1.3697
0.01193
0.99574
MDA-MB-468 Etoposide
Topo II
Chemotherapy
0.48754
 -0.5132 0.4291 0.1644 1.8475
0.69756
0.99577
MDA-MB-468 Neratinib
EGFR/HER2
RTK
0.15781
 -0.3825 0.3861 0.1513 0.8303
0.41607
0.99579
MDA-MB-231 Ceritinib
ALK
RTK
0.86565
 -0.3326 0.3444 0.1014 1.9065
1.1609
0.99581
HCC1937 Ceritinib
ALK
RTK
3.5257
 -0.5730 0.1368 0.0730 2.2956
5.6897
0.99584
HCC1428 Ceritinib
ALK
RTK
1.2414
 -0.8673 0.3014 0.1288 1.6178
2.4481
0.99584
BT-549 Volasertib
PLK
Cell cycle
0.0088352
 -0.2289 0.5676 0.1490 2.4967
0.0098732
0.99586
MDA-MB-231 ABT-737
Bcl2/XL
Misc
3.031
 -0.1204 0.1616 0.0795 1.1097
8.1572
0.99586