Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 Ipatasertib
AKT
PI3K/mTOR
3.3435
 0.3560 0.1553 0.0254 0.8518
1.1231
0.9503
HCC70 Bleomycin
Radiation
Misc
0.39804
 -0.1146 0.4192 0.0530 0.9765
0.54995
0.95046
BT-549 Cabozantinib
VEGFR2/MET
RTK
10.1855
 0.5329 0.0124 0.0096 5.0000
12.5665
0.95054
CAMA-1 Bleomycin
Radiation
Misc
1.6866
 -0.0365 0.2741 0.0341 0.6542
9.0438
0.951
HCC1428 Abemaciclib
CDK4/6
Cell cycle
0.0097947
 0.0492 0.6359 0.0146 0.9863
0.0062766
0.95101
SUM1315MO2 Cisplatin
Chemo
Chemotherapy
1.275
 0.2028 0.2961 0.0592 0.4798
3.6243
0.95111
PDX1328 Cediranib
VEGFR/cKIT
RTK
0.95412
 -0.8534 0.3764 0.0972 1.1127
2.5609
0.95134
HCC70 Alpelisib
PI3Ka
PI3K/mTOR
4.4987
 0.0981 0.1182 0.0196 1.0448
12.8744
0.95143
T47D Dasatinib
BCR/ABL
MAPK/nRTK
12.5697
 0.4961 0.1933 0.0086 0.2753
679.7315
0.95229
PDXHCI002 Dasatinib
BCR/ABL
MAPK/nRTK
0.50855
 0.0322 0.3757 0.0065 0.4070
3.0924
0.95256
SUM159PT Abemaciclib
CDK4/6
Cell cycle
0.28398
 -0.4677 0.4585 0.1015 0.4799
2.802
0.95259
CAMA-1 Cisplatin
Chemo
Chemotherapy
0.91281
 -0.0042 0.3350 0.0351 0.4780
9.0889
0.95264
BT-20 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.018077
 -0.3749 0.7363 0.2005 0.7541
0.028401
0.95352
HME1 Topotecan
Topo I
Chemotherapy
0.0072669
 -0.3399 0.8727 0.2534 1.2621
0.0091245
0.95352
HCC1419 Olaparib
PARP
Misc
Inf
 0.6322 0.0273 -0.0012 2.1535
5.2752
0.95353
MDA-MB-157 Pictilisib
pan PI3K
PI3K/mTOR
2.0533
 0.1874 0.2583 0.0226 0.3801
36.9459
0.95358
MCF7 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0083619
 -0.2545 0.7677 0.1823 0.5107
0.014367
0.95432
MCF7 Abemaciclib
CDK4/6
Cell cycle
0.023572
 -0.2684 0.7018 0.0913 0.3795
0.13917
0.95433
Hs 578T Taxol
Chemo
Chemotherapy
0.0010154
 -0.3752 0.9535 0.4788 1.2811
0.0015458
0.95438
PDXHCI002 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.6002
 -0.1369 0.3740 0.0320 0.4025
9.1998
0.95462
MDA-MB-468 Taxol
Chemo
Chemotherapy
0.001354
 -0.5218 1.0076 0.5243 1.2795
0.0023644
0.95471
PDX1328 Ipatasertib
AKT
PI3K/mTOR
4.7978
 0.3012 0.1323 0.0153 0.6377
26.7942
0.95509
MDA-MB-453 Saracatinib
SRC
MAPK/nRTK
8.3734
 0.3925 0.0634 0.0273 1.5016
17.4019
0.95549
SK-BR-3 Cabozantinib
VEGFR2/MET
RTK
9.7073
 0.4422 0.0013 0.0011 5.0000
12.0523
0.95604
HCC1806 Topotecan
Topo I
Chemotherapy
0.0052709
 -0.5458 1.0747 0.3515 1.0834
0.0094879
0.95633