Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-51 Olaparib
PARP
Misc
7.1917
 0.3596 0.1163 0.0073 0.8214
27.3972
0.94373
HCC1428 Cabozantinib
VEGFR2/MET
RTK
Inf
 0.6310 0.0204 -0.0008 2.9241
4.2982
0.94377
HCC1395 TGX221
PI3Kb
PI3K/mTOR
8.4625
 0.4581 0.0950 0.0125 0.6815
16.0341
0.94431
PDX1328 Topotecan
Topo I
Chemotherapy
0.0059222
 -0.9128 1.0720 0.1509 0.4616
0.063175
0.94441
SUM1315MO2 Abemaciclib
CDK4/6
Cell cycle
0.049304
 -0.1445 0.5815 0.0291 0.5067
0.075697
0.94514
HCC1419 Topotecan
Topo I
Chemotherapy
0.0071886
 -0.7857 0.9904 0.1711 0.4002
0.11192
0.94532
HCC1500 Olaparib
PARP
Misc
6.3506
 0.2744 0.0985 0.0084 1.0887
17.4212
0.94589
HCC1419 Doxorubicin
Chemo
Chemotherapy
0.025082
 -0.4663 0.5904 0.0473 0.5199
0.10425
0.94593
HCC1954 ABT-737
Bcl2/XL
Misc
9.9512
 0.4962 0.0404 0.0618 1.0240
27.9634
0.94601
MCF 10A A-1210477
Mcl-1
Misc
Inf
 0.9527 0.0018 0.0006 4.5125
3.8181
0.94609
HCC1937 Alpelisib
PI3Ka
PI3K/mTOR
18.8171
 0.6577 0.0501 0.0085 0.8078
73.2808
0.94623
MDA-MB-134-VI Ipatasertib
AKT
PI3K/mTOR
8.0392
 0.4925 0.0150 0.0096 4.9968
3.7717
0.94642
PDX1258 Ipatasertib
AKT
PI3K/mTOR
4.4024
 0.3985 0.1556 0.0120 0.7553
1.2185
0.94717
HCC1143 Topotecan
Topo I
Chemotherapy
0.0094142
 -0.4304 0.9040 0.3002 1.1711
0.013874
0.94725
HCC38 Saracatinib
SRC
MAPK/nRTK
29.3313
 0.6139 0.1013 0.0162 0.4862
24.1837
0.94737
BT-20 Olaparib
PARP
Misc
15.2735
 0.6064 0.0657 0.0087 0.8235
57.982
0.94742
MDA-MB-134-VI Pictilisib
pan PI3K
PI3K/mTOR
2.6892
 -0.1516 0.1775 0.0232 0.9649
8.3966
0.94749
PDXHCI002 Topotecan
Topo I
Chemotherapy
0.0066461
 -0.7006 1.0199 0.1157 0.8130
0.015555
0.94766
PDX1328 Dasatinib
BCR/ABL
MAPK/nRTK
0.035818
 -0.3368 0.6929 0.0612 0.7466
0.064434
0.94799
PDX1258 Olaparib
PARP
Misc
11.9912
 0.5770 0.0287 0.0113 1.2287
29.2905
0.94883
MCF7 Taxol
Chemo
Chemotherapy
0.0013771
 -0.1059 0.7722 0.1589 1.1560
0.0016261
0.94939
MDA-MB-468 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7230 0.1032 0.0343 0.5264
0.7426
0.94963
HCC70 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0058452
 -0.5550 0.6451 0.1234 0.5307
0.026938
0.94991
SUM1315MO2 Olaparib
PARP
Misc
2.0295
 0.0911 0.2452 0.0432 0.5075
17.6824
0.94995
CAL-120 Abemaciclib
CDK4/6
Cell cycle
0.247
 -0.1408 0.4780 0.0849 0.3730
4.696
0.95026