Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-468 Volasertib
PLK
Cell cycle
0.002104
 -0.4485 0.9279 0.3934 2.9173
0.0026072
0.99938
PDX1258 Taxol
Chemo
Chemotherapy
0.0021522
 -0.0818 0.6797 0.2357 1.2501
0.0022935
0.98829
CAMA-1 Taxol
Chemo
Chemotherapy
0.0022699
 -0.4944 0.9525 0.3547 2.4920
0.0029769
0.99478
SK-BR-3 Luminespib
HSP90
Misc
0.0022783
 -0.0766 0.7140 0.1099 2.5203
0.0024311
0.9977
MDA-MB-231 Taxol
Chemo
Chemotherapy
0.0023185
 -0.1204 0.7021 0.2576 1.1720
0.0026636
0.96432
MDA-MB-453 Taxol
Chemo
Chemotherapy
0.002374
 0.0356 0.6674 0.1683 1.2620
0.0023576
0.81734
PDX1328 Luminespib
HSP90
Misc
0.0023764
 -0.4697 0.8697 0.1444 1.9222
0.0032941
0.9864
HCC1937 Taxol
Chemo
Chemotherapy
0.0024514
 0.0104 0.6576 0.2104 2.2541
0.0024561
0.99541
SUM1315MO2 Taxol
Chemo
Chemotherapy
0.0024623
 -0.3258 0.7931 0.2940 2.0093
0.0030737
0.99498
HCC1954 Taxol
Chemo
Chemotherapy
0.0024667
 -0.3961 0.8347 0.4142 1.6514
0.0034177
0.98666
PDXHCI002 Taxol
Chemo
Chemotherapy
0.0024935
 -0.5117 0.9207 0.3881 2.7479
0.0031656
0.99139
PDX1328 Volasertib
PLK
Cell cycle
0.0025124
 -0.5731 0.9694 0.2182 2.8453
0.0032751
0.99856
HCC1395 Everolimus
mTOR1
PI3K/mTOR
0.0025601
 0.4042 0.5551 0.0370 0.4448
5.3346e-05
0.76727
Hs 578T Volasertib
PLK
Cell cycle
0.0025675
 -0.3123 0.8198 0.3337 3.0081
0.0029864
0.9987
MDA-MB-231 Trametinib
MEK
MAPK/nRTK
0.0026306
 -0.1785 0.7224 0.2816 1.1618
0.0033911
0.99829
SK-BR-3 INK-128
mTORC1/2
PI3K/mTOR
0.0026508
 -0.5064 0.9712 0.2693 1.0983
0.0044617
0.98817
MCF 10A Taxol
Chemo
Chemotherapy
0.0026843
 -0.1256 0.7023 0.2576 1.8234
0.003018
0.9967
MCF7 Everolimus
mTOR1
PI3K/mTOR
0.0026919
 0.3865 0.5643 0.0341 0.2603
1.8439e-05
0.90097
MDA-MB-134-VI Volasertib
PLK
Cell cycle
0.0027209
 -0.6274 1.0260 0.2671 5.0000
0.0032225
0.99553
BT-549 Taxol
Chemo
Chemotherapy
0.0027257
 -0.2074 0.6989 0.2304 1.9420
0.0030953
0.98743
CAL-85-1 Taxol
Chemo
Chemotherapy
0.0027273
 -0.3464 0.7931 0.3351 2.0210
0.0033785
0.95638
HCC1395 Topotecan
Topo I
Chemotherapy
0.0027504
 -0.5835 1.0761 0.3115 0.5889
0.0088299
0.93292
HCC1806 Volasertib
PLK
Cell cycle
0.0027998
 -0.1323 0.7262 0.2950 5.0000
0.0029495
0.99776
CAL-120 Luminespib
HSP90
Misc
0.0028134
 -0.1149 0.6933 0.1709 1.6073
0.0031386
0.99357
HCC1428 Luminespib
HSP90
Misc
0.0028629
 -0.0043 0.6375 0.0972 5.0000
0.0028677
0.99886