Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Taxol | Chemo | Chemotherapy | 0.0013411 | -0.5065 | 0.9773 | 0.3742 | 1.1642 | 0.0024269 | 0.99734 |
| SK-BR-3 | Luminespib | HSP90 | Misc | 0.0022783 | -0.0766 | 0.7140 | 0.1099 | 2.5203 | 0.0024311 | 0.9977 |
| HCC1937 | Taxol | Chemo | Chemotherapy | 0.0024514 | 0.0104 | 0.6576 | 0.2104 | 2.2541 | 0.0024561 | 0.99541 |
| HCC1143 | Taxol | Chemo | Chemotherapy | 0.0020688 | -0.3349 | 0.8388 | 0.3074 | 2.5955 | 0.0024565 | 0.99279 |
| T47D | Doxorubicin | Chemo | Chemotherapy | 0.0018887 | -0.3611 | 0.9189 | 0.1014 | 1.2268 | 0.0024801 | 0.96538 |
| SK-BR-3 | Neratinib | EGFR/HER2 | RTK | 0.0016518 | -0.2530 | 0.8909 | 0.2029 | 0.7723 | 0.0025421 | 0.9721 |
| MDA-MB-468 | Volasertib | PLK | Cell cycle | 0.002104 | -0.4485 | 0.9279 | 0.3934 | 2.9173 | 0.0026072 | 0.99938 |
| MDA-MB-231 | Taxol | Chemo | Chemotherapy | 0.0023185 | -0.1204 | 0.7021 | 0.2576 | 1.1720 | 0.0026636 | 0.96432 |
| HCC1500 | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.0017504 | -0.4967 | 0.9053 | 0.2022 | 1.3577 | 0.0027734 | 0.99119 |
| MCF7 | Trametinib | MEK | MAPK/nRTK | Inf | 0.5581 | 0.2767 | 0.0114 | 1.2083 | 0.0027903 | 0.99413 |
| MCF7 | INK-128 | mTORC1/2 | PI3K/mTOR | 0.00298 | -0.0450 | 0.7258 | 0.1347 | 1.1028 | 0.0028216 | 0.99089 |
| MCF7 | Volasertib | PLK | Cell cycle | 0.0028671 | -0.0338 | 0.6070 | 0.1245 | 4.2176 | 0.002824 | 0.99423 |
| HCC1428 | Luminespib | HSP90 | Misc | 0.0028629 | -0.0043 | 0.6375 | 0.0972 | 5.0000 | 0.0028677 | 0.99886 |
| BT-20 | Taxol | Chemo | Chemotherapy | 0.0020158 | -0.5760 | 0.9854 | 0.4456 | 2.0677 | 0.0028795 | 0.99355 |
| MDA-MB-134-VI | Trametinib | MEK | MAPK/nRTK | 0.0020578 | -0.2707 | 0.7601 | 0.0782 | 1.0824 | 0.0028809 | 0.99008 |
| MDA-MB-157 | Taxol | Chemo | Chemotherapy | 0.002046 | -0.6700 | 0.9482 | 0.3487 | 1.9966 | 0.0029397 | 0.97064 |
| HCC1806 | Volasertib | PLK | Cell cycle | 0.0027998 | -0.1323 | 0.7262 | 0.2950 | 5.0000 | 0.0029495 | 0.99776 |
| CAMA-1 | Taxol | Chemo | Chemotherapy | 0.0022699 | -0.4944 | 0.9525 | 0.3547 | 2.4920 | 0.0029769 | 0.99478 |
| Hs 578T | Volasertib | PLK | Cell cycle | 0.0025675 | -0.3123 | 0.8198 | 0.3337 | 3.0081 | 0.0029864 | 0.9987 |
| MCF 10A | Taxol | Chemo | Chemotherapy | 0.0026843 | -0.1256 | 0.7023 | 0.2576 | 1.8234 | 0.003018 | 0.9967 |
| SUM1315MO2 | Taxol | Chemo | Chemotherapy | 0.0024623 | -0.3258 | 0.7931 | 0.2940 | 2.0093 | 0.0030737 | 0.99498 |
| BT-549 | Taxol | Chemo | Chemotherapy | 0.0027257 | -0.2074 | 0.6989 | 0.2304 | 1.9420 | 0.0030953 | 0.98743 |
| CAL-120 | Luminespib | HSP90 | Misc | 0.0028134 | -0.1149 | 0.6933 | 0.1709 | 1.6073 | 0.0031386 | 0.99357 |
| PDXHCI002 | Taxol | Chemo | Chemotherapy | 0.0024935 | -0.5117 | 0.9207 | 0.3881 | 2.7479 | 0.0031656 | 0.99139 |
| MDA-MB-134-VI | Volasertib | PLK | Cell cycle | 0.0027209 | -0.6274 | 1.0260 | 0.2671 | 5.0000 | 0.0032225 | 0.99553 |