Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Olaparib | PARP | Misc | 27.0584 | 0.7191 | 0.0232 | -0.0045 | 0.7530 | 116.2527 | 0.78542 |
| HCC1500 | Ipatasertib | AKT | PI3K/mTOR | Inf | 1.0500 | -0.0314 | -0.0045 | 0.0000 | Inf | -1.0541 |
| CAMA-1 | Abemaciclib | CDK4/6 | Cell cycle | 0.007859 | 0.2222 | 0.6130 | -0.0040 | 1.3608 | 0.0046978 | 0.97968 |
| PDXHCI002 | Alpelisib | PI3Ka | PI3K/mTOR | 30.4631 | 0.6296 | 0.0630 | -0.0034 | 0.7047 | 10.7379 | 0.92415 |
| BT-20 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0152 | -0.0415 | -0.0034 | 0.0000 | Inf | -7.4504 |
| MDA-MB-134-VI | A-1210477 | Mcl-1 | Misc | Inf | 1.0500 | -0.0366 | -0.0033 | 0.0000 | Inf | -3.0589 |
| HCC1806 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 1.0500 | -0.0207 | -0.0033 | 0.0000 | Inf | -0.67606 |
| CAL-120 | Ipatasertib | AKT | PI3K/mTOR | 58.682 | 0.5993 | 0.1297 | -0.0033 | 0.4437 | 5.6283 | 0.9635 |
| HCC1143 | Palbociclib | CDK4/6 | Cell cycle | 0.27702 | 0.2820 | 0.2546 | -0.0033 | 0.9158 | 0.11143 | 0.98993 |
| HCC1419 | Trametinib | MEK | MAPK/nRTK | 0.031029 | 0.4259 | 0.2875 | -0.0031 | 1.4893 | 0.0089457 | 0.98063 |
| HCC1419 | Abemaciclib | CDK4/6 | Cell cycle | 0.10375 | 0.2278 | 0.4350 | -0.0030 | 0.6549 | 0.0234 | 0.9117 |
| MDA-MB-134-VI | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8589 | -0.0381 | -0.0029 | 0.0000 | Inf | 0.38211 |
| MCF 10A | Alpelisib | PI3Ka | PI3K/mTOR | 17.193 | 0.5787 | 0.1126 | -0.0029 | 0.4411 | 201.6709 | 0.99492 |
| MCF 10A | INK-128 | mTORC1/2 | PI3K/mTOR | 0.024199 | 0.1716 | 0.4673 | -0.0027 | 1.3149 | 0.017581 | 0.99992 |
| MDA-MB-134-VI | PF-4708671 | p70S6K | PI3K/mTOR | 11.8417 | 0.7092 | -0.0287 | -0.0026 | 5.0000 | 12.2595 | 0.80506 |
| MCF 10A | Pictilisib | pan PI3K | PI3K/mTOR | 1.8745 | 0.1934 | 0.2623 | -0.0025 | 0.4160 | 26.2875 | 0.97592 |
| CAMA-1 | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.6790 | 0.1521 | -0.0025 | 0.1987 | 999.7954 | 0.90943 |
| PDX1328 | Olaparib | PARP | Misc | Inf | 0.7634 | 0.0268 | -0.0025 | 5.0000 | 1.7254 | 0.86133 |
| CAL-120 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9240 | 0.0139 | -0.0025 | 0.0000 | Inf | 0.39826 |
| SUM159PT | Pictilisib | pan PI3K | PI3K/mTOR | 1.2625 | 0.0942 | 0.2390 | -0.0024 | 0.9852 | 1.2984 | 0.99746 |
| HCC1143 | Ipatasertib | AKT | PI3K/mTOR | 80.6794 | 0.7509 | 0.0662 | -0.0023 | 0.4354 | 999.9134 | 0.83579 |
| MCF 10A | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.7207 | 0.0475 | -0.0020 | 1.0315 | 4.381 | 0.99443 |
| HCC1806 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9450 | 0.0145 | -0.0020 | 0.0000 | Inf | 0.32254 |
| PDX1328 | Palbociclib | CDK4/6 | Cell cycle | 0.028878 | 0.1110 | 0.4289 | -0.0020 | 1.3039 | 0.020889 | 0.9674 |
| MCF 10A | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.6472 | 0.0600 | -0.0019 | 1.0758 | 4.7959 | 0.99868 |