Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Taxol | Chemo | Chemotherapy | 0.0020158 | -0.5760 | 0.9854 | 0.4456 | 2.0677 | 0.0028795 | 0.99355 |
| BT-20 | AZD7762 | CHK1/2 | Cell cycle | 1.081 | -0.5785 | 0.2831 | 0.1722 | 1.5948 | 1.8464 | 0.99406 |
| BT-20 | Volasertib | PLK | Cell cycle | 0.0056337 | -0.5339 | 0.7904 | 0.3461 | 2.3226 | 0.0076094 | 0.99851 |
| BT-20 | Dinaciclib | pan CDK | Cell cycle | 0.018482 | -0.6979 | 0.6791 | 0.3193 | 3.4864 | 0.02362 | 0.99822 |
| BT-20 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0152 | -0.0415 | -0.0034 | 0.0000 | Inf | -7.4504 |
| BT-20 | Palbociclib | CDK4/6 | Cell cycle | 0.043794 | 0.1624 | 0.3972 | 0.0216 | 1.2275 | 0.030066 | 0.99055 |
| BT-20 | Dasatinib | BCR/ABL | MAPK/nRTK | 0.67985 | 0.2835 | 0.3289 | 0.0839 | 0.5423 | 0.27245 | 0.98321 |
| BT-20 | Luminespib | HSP90 | Misc | 0.005967 | -0.0490 | 0.5621 | 0.1453 | 4.4759 | 0.0060667 | 0.99656 |
| BT-20 | A-1210477 | Mcl-1 | Misc | 14.9935 | 0.8209 | -0.0262 | 0.0007 | 4.9994 | 12.3309 | 0.67398 |
| BT-549 | Dasatinib | BCR/ABL | MAPK/nRTK | 0.59323 | 0.3705 | 0.2386 | 0.0271 | 1.7859 | 0.13859 | 0.96413 |
| BT-549 | Etoposide | Topo II | Chemotherapy | 0.181 | -0.1948 | 0.4726 | 0.1408 | 1.1701 | 0.22766 | 0.99526 |
| BT-549 | Trametinib | MEK | MAPK/nRTK | 5.2409 | 0.5983 | 0.1292 | 0.0152 | 0.5005 | 0.36186 | 0.97942 |
| BT-549 | Taxol | Chemo | Chemotherapy | 0.0027257 | -0.2074 | 0.6989 | 0.2304 | 1.9420 | 0.0030953 | 0.98743 |
| BT-549 | Doxorubicin | Chemo | Chemotherapy | 0.006482 | -0.3312 | 0.7603 | 0.1972 | 1.5744 | 0.0079126 | 0.9824 |
| BT-549 | Topotecan | Topo I | Chemotherapy | 0.0084727 | -0.2410 | 0.8509 | 0.2269 | 1.4734 | 0.010061 | 0.9801 |
| BT-549 | Saracatinib | SRC | MAPK/nRTK | Inf | 0.5558 | 0.0348 | 0.0015 | 3.3790 | 3.6758 | 0.97565 |
| BT-549 | Volasertib | PLK | Cell cycle | 0.0088352 | -0.2289 | 0.5676 | 0.1490 | 2.4967 | 0.0098732 | 0.99586 |
| BT-549 | AZD7762 | CHK1/2 | Cell cycle | 0.066029 | -0.4824 | 0.6356 | 0.2312 | 1.6999 | 0.087287 | 0.97383 |
| BT-549 | Dinaciclib | pan CDK | Cell cycle | 0.012371 | -0.2923 | 0.5913 | 0.1485 | 3.7837 | 0.013904 | 0.99899 |
| BT-549 | Abemaciclib | CDK4/6 | Cell cycle | 3.9707 | 0.0333 | 0.1267 | 0.0188 | 1.2825 | 7.5655 | 0.99654 |
| BT-549 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0401 | -0.0011 | 0.0000 | Inf | -9.2879 |
| BT-549 | Cisplatin | Chemo | Chemotherapy | 1.016 | 0.0674 | 0.2835 | 0.0552 | 1.0827 | 1.0937 | 0.98489 |
| BT-549 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9359 | -0.0225 | 0.0062 | 0.0000 | Inf | 0.067883 |
| BT-549 | Luminespib | HSP90 | Misc | 0.0053858 | -0.1064 | 0.6123 | 0.1201 | 5.0000 | 0.0055748 | 0.99911 |
| BT-549 | Vorinostat | HDAC | Misc | 2.3739 | 0.1131 | 0.1887 | 0.0291 | 0.8756 | 3.9571 | 0.99525 |