Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1395 Olaparib
PARP
Misc
1.8714
 0.0945 0.2530 0.0681 0.4756
18.8563
0.97211
HCC1395 Bleomycin
Radiation
Misc
0.10419
 -0.4023 0.6070 0.1775 0.6889
0.30452
0.9971
HCC1395 Ipatasertib
AKT
PI3K/mTOR
0.93351
 0.1903 0.2795 0.0199 0.6198
0.7738
0.97632
HCC1395 Everolimus
mTOR1
PI3K/mTOR
0.0025601
 0.4042 0.5551 0.0370 0.4448
5.3346e-05
0.76727
HCC1395 ABT-737
Bcl2/XL
Misc
Inf
 0.8607 -0.0001 0.0132 4.9721
4.7028
0.58916
HCC1395 Vorinostat
HDAC
Misc
3.2812
 -0.0589 0.1137 0.0365 2.1496
3.8175
0.99171
HCC1395 Saracatinib
SRC
MAPK/nRTK
3.7809
 0.1199 0.1181 0.0202 0.9275
10.2114
0.93832
HCC1395 Luminespib
HSP90
Misc
0.0049953
 -0.1520 0.6195 0.0752 3.9193
0.0052747
0.99634
HCC1395 Dasatinib
BCR/ABL
MAPK/nRTK
0.074545
 -0.3369 0.6018 0.0918 1.9595
0.089698
0.98974
HCC1395 A-1210477
Mcl-1
Misc
14.7951
 0.8591 0.0009 0.0010 5.0000
13.8656
0.73508
HCC1395 INK-128
mTORC1/2
PI3K/mTOR
0.010854
 -0.0258 0.5582 0.0314 1.5212
0.0094351
0.98264
HCC1395 Trametinib
MEK
MAPK/nRTK
0.17156
 0.4498 0.1903 0.0218 1.7439
0.023111
0.97973
HCC1395 Cisplatin
Chemo
Chemotherapy
0.49099
 -0.2215 0.3857 0.0943 0.9090
0.84369
0.97444
HCC1395 Doxorubicin
Chemo
Chemotherapy
0.01793
 -0.4166 0.6370 0.1543 1.1158
0.025315
0.96347
HCC1395 Dinaciclib
pan CDK
Cell cycle
0.012405
 -0.4966 0.6520 0.1554 2.9854
0.015612
0.99791
HCC1395 Taxol
Chemo
Chemotherapy
0.003883
 -0.4582 0.8386 0.2364 2.6973
0.0049059
0.99722
HCC1395 Palbociclib
CDK4/6
Cell cycle
0.096119
 0.3481 0.2811 0.0192 1.5258
0.037341
0.98658
HCC1395 AZD7762
CHK1/2
Cell cycle
0.02128
 -0.6899 0.8845 0.2607 2.2723
0.028104
0.96763
HCC1395 Volasertib
PLK
Cell cycle
0.0032085
 -0.2962 0.7641 0.1714 2.7096
0.00378
0.99662
HCC1395 Topotecan
Topo I
Chemotherapy
0.0027504
 -0.5835 1.0761 0.3115 0.5889
0.0088299
0.93292
HCC1395 Etoposide
Topo II
Chemotherapy
0.42007
 -0.2253 0.3885 0.1200 1.3744
0.55409
0.99622
HCC1395 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.6588 0.0192 0.0018 1.5703
5.6441
0.9103
HCC1419 Neratinib
EGFR/HER2
RTK
0.0011485
 -0.5015 0.9927 0.1818 0.5367
0.0038194
0.97246
HCC1419 Tivantinib
MET
RTK
0.47955
 0.1634 0.2618 0.0408 2.6512
0.40663
0.98985
HCC1419 Cediranib
VEGFR/cKIT
RTK
5.0599
 -0.0329 0.0545 0.0124 4.9952
5.1984
0.99032