Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-120 Ipatasertib
AKT
PI3K/mTOR
58.682
 0.5993 0.1297 -0.0033 0.4437
5.6283
0.9635
PDX1328 Ipatasertib
AKT
PI3K/mTOR
4.7978
 0.3012 0.1323 0.0153 0.6377
26.7942
0.95509
HCC1500 Ipatasertib
AKT
PI3K/mTOR
Inf
 1.0500 -0.0314 -0.0045 0.0000
Inf
-1.0541
SUM159PT Ipatasertib
AKT
PI3K/mTOR
9.2403
 0.4884 0.1149 0.0020 0.9180
2.8242
0.99791
HCC1395 Ipatasertib
AKT
PI3K/mTOR
0.93351
 0.1903 0.2795 0.0199 0.6198
0.7738
0.97632
MDA-MB-468 Ipatasertib
AKT
PI3K/mTOR
2.3697
 0.3091 0.2229 0.0266 0.5702
1.4742
0.96355
HCC1954 Ipatasertib
AKT
PI3K/mTOR
1.4342
 0.2509 0.2145 0.0288 0.9249
0.80694
0.98539
PDXHCI002 Ipatasertib
AKT
PI3K/mTOR
Inf
 1.0500 -0.0488 -0.0112 0.0000
Inf
-59.6281
T47D Ipatasertib
AKT
PI3K/mTOR
0.13653
 0.1331 0.4303 0.0112 1.0853
0.10541
0.99474
HME1 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.6353 0.0365 0.0079 1.2722
3.6876
0.93611
HCC1937 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.5349 0.1565 0.0058 1.0014
0.36202
0.97156
CAL-85-1 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.4714 0.1662 -0.0047 1.3900
0.27338
0.96561
MCF 10A Ipatasertib
AKT
PI3K/mTOR
Inf
 0.6472 0.0600 -0.0019 1.0758
4.7959
0.99868
HCC70 Ipatasertib
AKT
PI3K/mTOR
0.1397
 -0.2624 0.4974 0.0860 0.8534
0.21677
0.98567
BT-549 Ipatasertib
AKT
PI3K/mTOR
12.6362
 0.4956 0.1735 0.0097 0.5079
1.6786
0.97652