Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
Hs 578T Olaparib
PARP
Misc
8.9082
 0.4435 0.0997 0.0101 1.0369
25.6993
0.93656
Hs 578T Ipatasertib
AKT
PI3K/mTOR
4.5924
 0.4423 0.2458 0.0093 0.5006
0.34659
0.98155
SK-BR-3 Cabozantinib
VEGFR2/MET
RTK
9.7073
 0.4422 0.0013 0.0011 5.0000
12.0523
0.95604
HCC1419 Palbociclib
CDK4/6
Cell cycle
0.48725
 0.4414 0.2239 -0.0054 1.2398
0.053717
0.97241
MDA-MB-231 Bleomycin
Radiation
Misc
6.333
 0.4365 0.1320 0.0030 1.0810
2.968
0.97684
HCC1419 Trametinib
MEK
MAPK/nRTK
0.031029
 0.4259 0.2875 -0.0031 1.4893
0.0089457
0.98063
HCC38 Olaparib
PARP
Misc
8.4247
 0.4254 0.0719 0.0230 1.0282
24.5229
0.97772
MDA-MB-468 Cabozantinib
VEGFR2/MET
RTK
8.9681
 0.4233 0.0441 0.0115 1.7711
16.6732
0.9812
Hs 578T Everolimus
mTOR1
PI3K/mTOR
0.0056053
 0.4204 0.5273 0.0278 0.4084
2.87e-05
0.64462
CAL-120 Trametinib
MEK
MAPK/nRTK
0.046732
 0.4153 0.2938 0.0276 1.2901
0.011053
0.98433
MDA-MB-468 Trametinib
MEK
MAPK/nRTK
0.4421
 0.4075 0.2132 0.0255 0.4592
0.27448
0.99227
MDA-MB-157 Trametinib
MEK
MAPK/nRTK
0.11147
 0.4063 0.3010 0.0221 0.6435
0.009777
0.98841
HCC1395 Everolimus
mTOR1
PI3K/mTOR
0.0025601
 0.4042 0.5551 0.0370 0.4448
5.3346e-05
0.76727
SUM1315MO2 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.4018 0.4539 0.0330 0.0000
Inf
0.42807
PDX1258 Ipatasertib
AKT
PI3K/mTOR
4.4024
 0.3985 0.1556 0.0120 0.7553
1.2185
0.94717
PDX1328 PF-4708671
p70S6K
PI3K/mTOR
8.0727
 0.3935 0.0744 0.0073 1.0548
22.8735
0.93815
MDA-MB-453 Saracatinib
SRC
MAPK/nRTK
8.3734
 0.3925 0.0634 0.0273 1.5016
17.4019
0.95549
BT-20 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.3900 0.5932 0.0889 0.0000
Inf
0.031152
T47D Saracatinib
SRC
MAPK/nRTK
3.9647
 0.3892 0.1722 0.0087 0.6928
1.6318
0.9752
HCC1143 Saracatinib
SRC
MAPK/nRTK
3.0304
 0.3881 0.2375 0.0437 0.4638
1.6973
0.97807
SUM159PT Palbociclib
CDK4/6
Cell cycle
1.1058
 0.3876 0.1990 -0.0006 0.6326
0.40763
0.99661
CAL-85-1 Olaparib
PARP
Misc
5.0606
 0.3870 0.1367 0.0158 0.7846
3.2235
0.97652
CAL-51 Ipatasertib
AKT
PI3K/mTOR
2.978
 0.3866 0.2238 0.0226 0.5898
0.68363
0.98798
MCF7 Everolimus
mTOR1
PI3K/mTOR
0.0026919
 0.3865 0.5643 0.0341 0.2603
1.8439e-05
0.90097
SUM1315MO2 Alpelisib
PI3Ka
PI3K/mTOR
6.462
 0.3829 0.1169 0.0203 0.5997
40.3568
0.94056