Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC38 Volasertib
PLK
Cell cycle
0.0081934
 -0.2598 0.6001 0.1943 3.2088
0.0091367
0.99678
HCC38 Dinaciclib
pan CDK
Cell cycle
0.012678
 -0.4422 0.6326 0.2241 4.1199
0.014763
0.99821
HCC38 Cisplatin
Chemo
Chemotherapy
0.99272
 -0.1031 0.2567 0.1098 1.4350
1.1794
0.99675
HCC38 Doxorubicin
Chemo
Chemotherapy
0.0095452
 -0.4061 0.7803 0.2872 1.4810
0.01343
0.99228
HCC38 Taxol
Chemo
Chemotherapy
0.0014659
 -0.3078 0.8432 0.2758 2.3201
0.0017274
0.99328
HCC38 Topotecan
Topo I
Chemotherapy
0.0068073
 -0.5041 1.0724 0.3904 1.2181
0.011735
0.99338
HCC38 Etoposide
Topo II
Chemotherapy
0.33384
 -0.4242 0.4494 0.1891 1.4384
0.50554
0.99763
HCC38 Dasatinib
BCR/ABL
MAPK/nRTK
5.6901
 0.3322 0.1453 0.0365 0.6048
34.9918
0.97158
HCC38 Trametinib
MEK
MAPK/nRTK
0.22023
 0.1854 0.2076 0.0234 0.6910
0.35783
0.98881
HCC38 Saracatinib
SRC
MAPK/nRTK
29.3313
 0.6139 0.1013 0.0162 0.4862
24.1837
0.94737
HCC38 ABT-737
Bcl2/XL
Misc
0.99805
 -0.4209 0.2963 0.1000 0.9364
2.8897
0.99657
HCC38 Vorinostat
HDAC
Misc
0.95999
 -0.2851 0.2909 0.1227 1.6239
1.3226
0.99701
HCC38 Luminespib
HSP90
Misc
0.0071367
 -0.2087 0.6295 0.1926 5.0000
0.0076296
0.99771
HCC38 A-1210477
Mcl-1
Misc
14.9391
 0.8870 0.0151 0.0032 4.9989
15.3353
0.65537
HCC38 Olaparib
PARP
Misc
8.4247
 0.4254 0.0719 0.0230 1.0282
24.5229
0.97772
HCC38 Bleomycin
Radiation
Misc
0.19854
 -0.2318 0.4852 0.1896 1.1991
0.27457
0.99721
HCC38 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.7055 0.1225 0.0092 1.1410
0.22841
0.9721
HCC38 Alpelisib
PI3Ka
PI3K/mTOR
22.4126
 0.6801 0.0440 0.0092 0.7155
102.9667
0.92013
HCC38 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.7028
 0.0628 0.2018 0.0249 0.6728
13.8343
0.97542
HCC38 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9515 -0.0246 0.0013 0.0000
Inf
-0.17011
HCC38 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.01047
 -0.2107 0.5383 0.0927 0.8737
0.015621
0.99367
HCC38 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.4735 0.4865 0.0140 0.0000
Inf
0.060078
HCC38 INK-128
mTORC1/2
PI3K/mTOR
0.01911
 -0.0087 0.5361 0.0402 1.3664
0.018127
0.99621
HCC38 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.9760 -0.0258 -0.0006 0.0000
Inf
-0.90907
HCC38 Buparlisib
pan PI3K
PI3K/mTOR
1.2697
 -0.2762 0.2554 0.0711 1.4831
1.8745
0.99552