Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| SUM1315MO2 | Topotecan | 3.1623 | Topo I | Chemotherapy | -0.1166 | 0.33834 |
| MDA-MB-231 | Ipatasertib | 3.1623 | AKT | PI3K/mTOR | 1.0049 | -0.00480 |
| MCF7 | Topotecan | 3.1623 | Topo I | Chemotherapy | -0.1545 | 0.27758 |
| BT-20 | Taselisib | 3.1623 | PI3Ka, g, d | PI3K/mTOR | -0.1041 | 0.36006 |
| HCC1806 | ABT-737 | 3.1623 | Bcl2/XL | Misc | 1.1888 | 0.00960 |
| MDA-MB-157 | AZD7762 | 3.1623 | CHK1/2 | Cell cycle | -0.6731 | 0.55132 |
| HCC1419 | Ceritinib | 3.1623 | ALK | RTK | 0.3238 | 0.00545 |
| T47D | Ipatasertib | 3.1623 | AKT | PI3K/mTOR | 0.1331 | 0.02540 |
| HCC1954 | ABT-737 | 3.1623 | Bcl2/XL | Misc | 0.8263 | 0.14531 |
| BT-20 | Bleomycin | 3.1623 | Radiation | Misc | -0.0603 | 0.30083 |
| MDA-MB-157 | Topotecan | 3.1623 | Topo I | Chemotherapy | -0.7299 | 0.63056 |
| SUM1315MO2 | Dasatinib | 3.1623 | BCR/ABL | MAPK/nRTK | -0.1622 | 0.26947 |
| HCC1806 | Buparlisib | 3.1623 | pan PI3K | PI3K/mTOR | -0.1855 | 0.49892 |
| CAL-85-1 | Cediranib | 3.1623 | VEGFR/cKIT | RTK | 0.3863 | 0.11888 |
| MCF 10A | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.4544 | -0.00579 |
| Hs 578T | Taselisib | 3.1623 | PI3Ka, g, d | PI3K/mTOR | 0.2467 | 0.13162 |
| HCC1143 | Saracatinib | 3.1623 | SRC | MAPK/nRTK | 0.4818 | 0.10250 |
| MCF7 | Etoposide | 3.1623 | Topo II | Chemotherapy | -0.0441 | 0.04288 |
| BT-20 | Ipatasertib | 3.1623 | AKT | PI3K/mTOR | 0.2981 | 0.08956 |
| HCC1806 | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.3241 | 0.57687 |
| CAL-51 | Taselisib | 3.1623 | PI3Ka, g, d | PI3K/mTOR | -0.0046 | 0.33491 |
| MDA-MB-468 | INK-128 | 3.1623 | mTORC1/2 | PI3K/mTOR | 0.0573 | 0.21117 |
| HCC1419 | Bleomycin | 3.1623 | Radiation | Misc | 0.5469 | 0.01203 |
| MDA-MB-157 | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.7766 | 0.77243 |
| T47D | Taselisib | 3.1623 | PI3Ka, g, d | PI3K/mTOR | 0.0034 | 0.07274 |