Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC70 Trametinib
0.0001
MEK
MAPK/nRTK
 1.0478 0.01201
MCF7 Luminespib
0.0001
HSP90
Misc
 1.0129 -0.00003
MCF7 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 0.9564 0.00563
HCC70 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0432 0.00401
HCC1806 Volasertib
0.0001
PLK
Cell cycle
 1.0118 0.00039
MDA-MB-231 Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9345 0.00720
PDX1258 Luminespib
0.0001
HSP90
Misc
 1.0799 0.00305
MDA-MB-231 Volasertib
0.0001
PLK
Cell cycle
 1.0247 0.00180
MDA-MB-231 Taxol
0.0001
Chemo
Chemotherapy
 0.7633 0.02094
PDX1328 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0810 0.00602
Hs 578T Trametinib
0.0001
MEK
MAPK/nRTK
 0.9824 -0.00001
HCC1806 Luminespib
0.0001
HSP90
Misc
 1.0518 -0.00289
HCC1806 Taxol
0.0001
Chemo
Chemotherapy
 0.7362 0.03761
Hs 578T Luminespib
0.0001
HSP90
Misc
 0.9779 0.00503
Hs 578T Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0888 0.00475
MDA-MB-231 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0116 0.00659
SK-BR-3 Taxol
0.0001
Chemo
Chemotherapy
 0.6966 0.06856
MCF 10A Volasertib
0.0001
PLK
Cell cycle
 1.0023 0.00027
HCC1806 Trametinib
0.0001
MEK
MAPK/nRTK
 1.0301 0.00613
MCF 10A Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0083 0.00069
MCF 10A Taxol
0.0001
Chemo
Chemotherapy
 0.9571 0.00191
MCF 10A Luminespib
0.0001
HSP90
Misc
 0.9989 0.00064
HCC1806 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0433 -0.00285
MDA-MB-134-VI Taxol
0.0001
Chemo
Chemotherapy
 0.2401 0.22859
MDA-MB-134-VI Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0884 0.00731