Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A Trametinib
0.0001
MEK
MAPK/nRTK
 0.9875 -0.00048
HCC1806 Volasertib
0.0001
PLK
Cell cycle
 1.0118 0.00039
BT-549 Volasertib
0.0001
PLK
Cell cycle
 1.0344 -0.00418
BT-549 Taxol
0.0001
Chemo
Chemotherapy
 1.0080 0.01654
MCF 10A Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0023 -0.00057
Hs 578T Volasertib
0.0001
PLK
Cell cycle
 0.9564 -0.00165
Hs 578T Trametinib
0.0001
MEK
MAPK/nRTK
 0.9824 -0.00001
Hs 578T Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9649 0.00169
MCF7 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0167 -0.00027
HCC1806 Trametinib
0.0001
MEK
MAPK/nRTK
 1.0301 0.00613
HCC1806 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0433 -0.00285
Hs 578T Taxol
0.0001
Chemo
Chemotherapy
 0.6739 0.08314
MCF7 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 0.9564 0.00563
Hs 578T Luminespib
0.0001
HSP90
Misc
 0.9779 0.00503
HCC1806 Taxol
0.0001
Chemo
Chemotherapy
 0.7362 0.03761
HCC1806 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0343 -0.00199
MDA-MB-231 Trametinib
0.0001
MEK
MAPK/nRTK
 0.9350 0.00624
HCC1806 Luminespib
0.0001
HSP90
Misc
 1.0518 -0.00289
Hs 578T Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0888 0.00475
SK-BR-3 Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9624 0.01103
SK-BR-3 Taxol
0.0001
Chemo
Chemotherapy
 0.6966 0.06856
MCF 10A Taxol
0.0001
Chemo
Chemotherapy
 0.9571 0.00191
MCF 10A Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0083 0.00069
HCC38 Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9911 -0.00389
HCC38 Volasertib
0.0001
PLK
Cell cycle
 0.9979 0.00341