Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| T47D | AZD7762 | 3.1623 | CHK1/2 | Cell cycle | 0.2905 | 0.06193 |
| T47D | Volasertib | 0.0031623 | PLK | Cell cycle | 1.0642 | -0.00098 |
| T47D | Volasertib | 1.0 | PLK | Cell cycle | -0.1585 | 0.16311 |
| T47D | Volasertib | 0.001 | PLK | Cell cycle | 1.0155 | -0.00006 |
| T47D | Volasertib | 0.31623 | PLK | Cell cycle | -0.0906 | 0.16641 |
| T47D | Volasertib | 0.01 | PLK | Cell cycle | 0.8485 | 0.00521 |
| T47D | Volasertib | 0.1 | PLK | Cell cycle | -0.0044 | 0.13769 |
| T47D | Dinaciclib | 0.0031623 | pan CDK | Cell cycle | 1.1013 | -0.00122 |
| T47D | Cisplatin | 0.0010833 | Chemo | Chemotherapy | 1.0538 | -0.00313 |
| T47D | Trametinib | 0.0001 | MEK | MAPK/nRTK | 0.9279 | 0.00423 |
| T47D | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.2109 | 0.12913 |
| T47D | Dinaciclib | 0.031623 | pan CDK | Cell cycle | -0.0592 | 0.05833 |
| T47D | Topotecan | 0.0010833 | Topo I | Chemotherapy | 0.8845 | -0.00136 |
| T47D | Cisplatin | 0.1 | Chemo | Chemotherapy | 0.9180 | -0.00007 |
| T47D | Cisplatin | 0.0033333 | Chemo | Chemotherapy | 1.0424 | 0.00001 |
| T47D | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.8837 | 0.00193 |
| T47D | Cisplatin | 10.0 | Chemo | Chemotherapy | 0.1019 | 0.03321 |
| T47D | Cisplatin | 0.31623 | Chemo | Chemotherapy | 0.8420 | -0.00135 |
| T47D | Cisplatin | 3.1623 | Chemo | Chemotherapy | 0.2284 | 0.01447 |
| T47D | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.1901 | 0.17524 |
| T47D | Doxorubicin | 0.01 | Chemo | Chemotherapy | -0.0015 | 0.03141 |
| T47D | Taxol | 1.0 | Chemo | Chemotherapy | -0.1337 | 0.41010 |
| T47D | Doxorubicin | 0.0031623 | Chemo | Chemotherapy | 0.2335 | 0.02430 |
| T47D | Doxorubicin | 1.0 | Chemo | Chemotherapy | -0.3611 | 0.36359 |
| T47D | Doxorubicin | 0.031623 | Chemo | Chemotherapy | -0.0535 | 0.04115 |