Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
A-375 Vemurafenib PFI-1 1.0000 0.1067
uM
 48
hr
 2 2198 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 144.45 NGFR rabbit IgG(H+L) / donkey NGFR 167.49
A375-B2-rep2
B7
COLO 858 Vemurafenib C646 0.3160 2.6667
uM
 48
hr
 2 2543 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 313.83 NGFR rabbit IgG(H+L) / donkey NGFR 167.50
Colo858-A2-rep2
E3
A-375 Vemurafenib Decitabine 1.0000 0.5333
uM
 48
hr
 1 1887 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 172.55 NGFR rabbit IgG(H+L) / donkey NGFR 167.68
A375-B1-rep1
F2
A-375 Vemurafenib I-BET 1.0000 0.1067
uM
 48
hr
 2 2858 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 144.80 NGFR rabbit IgG(H+L) / donkey NGFR 167.95
A375-B2-rep2
E7
COLO 858 Vemurafenib Iniparib 0.3160 0.1067
uM
 48
hr
 2 1737 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 342.50 NGFR rabbit IgG(H+L) / donkey NGFR 168.06
Colo858-B2-rep2
B3
A-375 Vemurafenib Ischemin 1.0000 2.6667
uM
 48
hr
 2 1740 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 196.06 NGFR rabbit IgG(H+L) / donkey NGFR 168.62
A375-A2-rep2
G7
COLO 858 Vemurafenib (-)-JQ1 0.3160 0.1067
uM
 48
hr
 2 3368 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 384.19 NGFR rabbit IgG(H+L) / donkey NGFR 168.62
Colo858-B2-rep2
D7
A-375 Vemurafenib Garcinol 1.0000 0.1067
uM
 48
hr
 2 2577 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 178.61 NGFR rabbit IgG(H+L) / donkey NGFR 168.67
A375-B2-rep2
F3
COLO 858 Vemurafenib Rucaparib 0.3160 2.6667
uM
 48
hr
 2 2191 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 274.88 NGFR rabbit IgG(H+L) / donkey NGFR 168.71
Colo858-A2-rep2
C3
A-375 Vemurafenib Ischemin 1.0000 0.5333
uM
 48
hr
 2 1846 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 204.07 NGFR rabbit IgG(H+L) / donkey NGFR 168.74
A375-B1-rep2
G7
A-375 Vemurafenib Tranylcypromine 1.0000 0.5333
uM
 48
hr
 2 1765 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 166.51 NGFR rabbit IgG(H+L) / donkey NGFR 168.79
A375-B1-rep2
G6
COLO 858 Vemurafenib (-)-JQ1 0.3160 0.1067
uM
 48
hr
 1 3394 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 313.83 NGFR rabbit IgG(H+L) / donkey NGFR 168.87
Colo858-B2-rep1
D7
A-375 Vemurafenib Veliparib 1.0000 0.5333
uM
 48
hr
 1 2207 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 158.60 NGFR rabbit IgG(H+L) / donkey NGFR 168.87
A375-B1-rep1
C2
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2443 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 184.77 NGFR rabbit IgG(H+L) / donkey NGFR 168.94
A375-B2-rep1
A3
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2318 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 158.52 NGFR rabbit IgG(H+L) / donkey NGFR 169.15
A375-B1-rep1
A5
COLO 858 Vemurafenib Epigallocatechin gallate 0.3160 0.1067
uM
 48
hr
 1 2911 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 352.95 NGFR rabbit IgG(H+L) / donkey NGFR 169.38
Colo858-B2-rep1
E8
COLO 858 Vemurafenib Epigallocatechin gallate 0.3160 0.1067
uM
 48
hr
 2 3297 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 322.94 NGFR rabbit IgG(H+L) / donkey NGFR 169.39
Colo858-B2-rep2
E8
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 1 1105 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 336.45 NGFR rabbit IgG(H+L) / donkey NGFR 169.68
Colo858-B2-rep1
A9
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1350 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 187.39 NGFR rabbit IgG(H+L) / donkey NGFR 169.71
A375-A2-rep2
H2
A-375 Vemurafenib JW55 1.0000 0.1067
uM
 48
hr
 2 2703 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 149.09 NGFR rabbit IgG(H+L) / donkey NGFR 169.94
A375-B2-rep2
D3
A-375 Vemurafenib Anacardic acid 1.0000 2.6667
uM
 48
hr
 1 1318 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 145.31 NGFR rabbit IgG(H+L) / donkey NGFR 170.13
A375-A2-rep1
G3
COLO 858 Vemurafenib IOX2 0.3160 0.1067
uM
 48
hr
 1 3247 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 296.22 NGFR rabbit IgG(H+L) / donkey NGFR 170.23
Colo858-B2-rep1
D8
A-375 Vemurafenib Epigallocatechin gallate 1.0000 2.6667
uM
 48
hr
 1 2367 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 176.81 NGFR rabbit IgG(H+L) / donkey NGFR 170.27
A375-A2-rep1
E8
COLO 858 Vemurafenib UNC1215 0.3160 0.1067
uM
 48
hr
 2 2912 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 347.33 NGFR rabbit IgG(H+L) / donkey NGFR 170.30
Colo858-B2-rep2
C8
A-375 Vemurafenib Olaparib 1.0000 0.5333
uM
 48
hr
 1 2160 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 155.98 NGFR rabbit IgG(H+L) / donkey NGFR 170.41
A375-B1-rep1
B2