Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
A-375 Vemurafenib Decitabine 1.0000 2.6667
uM
 48
hr
 2 2092 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 222.42 NGFR rabbit IgG(H+L) / donkey NGFR 140.13
A375-A2-rep2
F2
A-375 Vemurafenib Pracinostat 1.0000 2.6667
uM
 48
hr
 2 215 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 234.28 NGFR rabbit IgG(H+L) / donkey NGFR 35.01
A375-A2-rep2
F4
A-375 Vemurafenib BIX-01294 1.0000 2.6667
uM
 48
hr
 2 1250 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 292.19 NGFR rabbit IgG(H+L) / donkey NGFR 42.51
A375-A2-rep2
F5
A-375 Vemurafenib I-BET151 1.0000 2.6667
uM
 48
hr
 2 1718 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 145.96 NGFR rabbit IgG(H+L) / donkey NGFR 72.08
A375-A2-rep2
F7
A-375 Vemurafenib CX-5461 1.0000 2.6667
uM
 48
hr
 2 1191 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 130.69 NGFR rabbit IgG(H+L) / donkey NGFR 133.97
A375-A2-rep2
F8
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1915 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 204.90 NGFR rabbit IgG(H+L) / donkey NGFR 199.36
A375-A2-rep2
A10
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1793 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 164.73 NGFR rabbit IgG(H+L) / donkey NGFR 197.31
A375-A2-rep2
A11
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 2177 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 175.69 NGFR rabbit IgG(H+L) / donkey NGFR 218.26
A375-A2-rep2
A3
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 2355 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 209.47 NGFR rabbit IgG(H+L) / donkey NGFR 230.86
A375-A2-rep2
A4
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1797 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 197.36 NGFR rabbit IgG(H+L) / donkey NGFR 224.46
A375-A2-rep2
A7
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1871 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 184.59 NGFR rabbit IgG(H+L) / donkey NGFR 210.13
A375-A2-rep2
A8
A-375 Vemurafenib Olaparib 1.0000 2.6667
uM
 48
hr
 2 2229 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 159.21 NGFR rabbit IgG(H+L) / donkey NGFR 210.77
A375-A2-rep2
B2
A-375 Vemurafenib Iniparib 1.0000 2.6667
uM
 48
hr
 2 2597 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 177.05 NGFR rabbit IgG(H+L) / donkey NGFR 176.99
A375-A2-rep2
B3
A-375 Vemurafenib PFI-1 1.0000 2.6667
uM
 48
hr
 2 2464 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 137.44 NGFR rabbit IgG(H+L) / donkey NGFR 154.43
A375-A2-rep2
B7
A-375 Vemurafenib UNC669 1.0000 2.6667
uM
 48
hr
 2 2373 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 210.68 NGFR rabbit IgG(H+L) / donkey NGFR 209.48
A375-A2-rep2
B8
A-375 Vemurafenib Rucaparib 1.0000 2.6667
uM
 48
hr
 2 2477 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 156.42 NGFR rabbit IgG(H+L) / donkey NGFR 200.11
A375-A2-rep2
C3
A-375 Vemurafenib Belinostat 1.0000 2.6667
uM
 48
hr
 2 319 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 360.58 NGFR rabbit IgG(H+L) / donkey NGFR 26.94
A375-A2-rep2
C4
A-375 Vemurafenib (+)-JQ1 1.0000 2.6667
uM
 48
hr
 2 2251 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 165.40 NGFR rabbit IgG(H+L) / donkey NGFR 86.81
A375-A2-rep2
C7
A-375 Vemurafenib UNC1215 1.0000 2.6667
uM
 48
hr
 2 2981 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 185.94 NGFR rabbit IgG(H+L) / donkey NGFR 204.11
A375-A2-rep2
C8
A-375 Vemurafenib JW55 1.0000 2.6667
uM
 48
hr
 2 2911 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 155.15 NGFR rabbit IgG(H+L) / donkey NGFR 159.22
A375-A2-rep2
D3
A-375 Vemurafenib Entinostat 1.0000 2.6667
uM
 48
hr
 2 3308 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 589.21 NGFR rabbit IgG(H+L) / donkey NGFR 306.13
A375-A2-rep2
D4
A-375 Vemurafenib Azacitidine 1.0000 2.6667
uM
 48
hr
 2 1303 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 286.33 NGFR rabbit IgG(H+L) / donkey NGFR 62.73
A375-A2-rep2
E2
A-375 Vemurafenib C646 1.0000 2.6667
uM
 48
hr
 2 2465 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 167.50 NGFR rabbit IgG(H+L) / donkey NGFR 173.88
A375-A2-rep2
E3
A-375 Vemurafenib Tranylcypromine 1.0000 2.6667
uM
 48
hr
 2 1762 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 188.67 NGFR rabbit IgG(H+L) / donkey NGFR 224.08
A375-A2-rep2
G6
A-375 Vemurafenib UNC0638 1.0000 2.6667
uM
 48
hr
 2 1362 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 190.15 NGFR rabbit IgG(H+L) / donkey NGFR 72.59
A375-A2-rep2
G5