Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib I-BET 3.1600 0.3160 0.0000
uM
 72
hr
 2 1410 662 0.2187 0.2088 0.4695 0.4815
WM-115 Vemurafenib Trametinib I-BET 3.1600 0.3160 0.0000
uM
 72
hr
 3 1338 639 0.2044 0.2088 0.4776 0.4815
WM-115 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 1 707 543 0.0479 0.0559 0.7680 0.7596
WM-115 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 2 887 702 0.0541 0.0559 0.7914 0.7596
WM-115 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 3 802 577 0.0658 0.0559 0.7195 0.7596
WM-115 Vemurafenib Trametinib I-BET151 0.0000 0.0000 0.0000
uM
 72
hr
 1 3813 221 1.0424 1.0000 0.0580 0.0587
WM-115 Vemurafenib Trametinib I-BET151 0.0000 0.0000 0.0000
uM
 72
hr
 2 3685 224 1.0044 1.0000 0.0608 0.0587
WM-115 Vemurafenib Trametinib I-BET151 0.0000 0.0000 0.0000
uM
 72
hr
 3 3485 200 0.9533 1.0000 0.0574 0.0587
WM-115 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 1 2847 156 0.7809 0.7502 0.0548 0.0571
WM-115 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 2 2826 160 0.7737 0.7502 0.0566 0.0571
WM-115 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 3 2552 153 0.6962 0.7502 0.0600 0.0571
WM-115 Vemurafenib Trametinib I-BET151 0.1000 0.0100 0.0000
uM
 72
hr
 1 1928 441 0.4315 0.4501 0.2287 0.2143
WM-115 Vemurafenib Trametinib I-BET151 0.1000 0.0100 0.0000
uM
 72
hr
 2 2007 413 0.4626 0.4501 0.2058 0.2143
WM-115 Vemurafenib Trametinib I-BET151 0.1000 0.0100 0.0000
uM
 72
hr
 3 1986 414 0.4562 0.4501 0.2085 0.2143
WM-115 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 1 1287 796 0.1425 0.1185 0.6185 0.6600
WM-115 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 2 1296 876 0.1219 0.1185 0.6759 0.6600
WM-115 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 3 999 685 0.0911 0.1185 0.6857 0.6600
WM-115 Vemurafenib Trametinib I-BET151 0.3160 0.0316 0.0000
uM
 72
hr
 1 1775 523 0.3633 0.3801 0.2946 0.2659
WM-115 Vemurafenib Trametinib I-BET151 0.3160 0.0316 0.0000
uM
 72
hr
 2 1764 453 0.3804 0.3801 0.2568 0.2659
WM-115 Vemurafenib Trametinib I-BET151 0.3160 0.0316 0.0000
uM
 72
hr
 3 1812 446 0.3964 0.3801 0.2461 0.2659
WM-115 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 1 1053 678 0.1088 0.0936 0.6439 0.6738
WM-115 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 2 1005 688 0.0920 0.0936 0.6846 0.6738
WM-115 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 3 899 623 0.0801 0.0936 0.6930 0.6738
WM-115 Vemurafenib Trametinib I-BET151 1.0000 0.1000 0.0000
uM
 72
hr
 1 1628 532 0.3180 0.3359 0.3268 0.2966
WM-115 Vemurafenib Trametinib I-BET151 1.0000 0.1000 0.0000
uM
 72
hr
 2 1669 460 0.3508 0.3359 0.2756 0.2966