Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 1 3652 225 1.0019 1.0000 0.0616 0.0597
WM-115 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 2 3643 214 1.0025 1.0000 0.0587 0.0597
WM-115 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 3 3617 212 0.9955 1.0000 0.0586 0.0597
WM-115 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 1 3137 190 0.8616 0.8640 0.0606 0.0525
WM-115 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 2 3247 152 0.9049 0.8640 0.0468 0.0525
WM-115 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 3 2972 149 0.8254 0.8640 0.0501 0.0525
WM-115 Vemurafenib Trametinib I-BET 0.1000 0.0100 0.0000
uM
 72
hr
 1 1926 470 0.4257 0.4443 0.2440 0.2238
WM-115 Vemurafenib Trametinib I-BET 0.1000 0.0100 0.0000
uM
 72
hr
 2 1996 430 0.4579 0.4443 0.2154 0.2238
WM-115 Vemurafenib Trametinib I-BET 0.1000 0.0100 0.0000
uM
 72
hr
 3 1950 413 0.4494 0.4443 0.2118 0.2238
WM-115 Vemurafenib Trametinib I-BET 0.1000 0.0100 1.0000
uM
 72
hr
 1 1432 947 0.1418 0.1368 0.6613 0.6352
WM-115 Vemurafenib Trametinib I-BET 0.1000 0.0100 1.0000
uM
 72
hr
 2 1284 828 0.1333 0.1368 0.6449 0.6352
WM-115 Vemurafenib Trametinib I-BET 0.1000 0.0100 1.0000
uM
 72
hr
 3 1156 693 0.1354 0.1368 0.5995 0.6352
WM-115 Vemurafenib Trametinib I-BET 0.3160 0.0316 0.0000
uM
 72
hr
 1 1937 559 0.4029 0.3800 0.2886 0.2843
WM-115 Vemurafenib Trametinib I-BET 0.3160 0.0316 0.0000
uM
 72
hr
 2 1729 486 0.3634 0.3800 0.2811 0.2843
WM-115 Vemurafenib Trametinib I-BET 0.3160 0.0316 0.0000
uM
 72
hr
 3 1783 505 0.3736 0.3800 0.2832 0.2843
WM-115 Vemurafenib Trametinib I-BET 0.3160 0.0316 1.0000
uM
 72
hr
 1 1086 753 0.0974 0.0978 0.6934 0.6770
WM-115 Vemurafenib Trametinib I-BET 0.3160 0.0316 1.0000
uM
 72
hr
 2 1068 727 0.0997 0.0978 0.6807 0.6770
WM-115 Vemurafenib Trametinib I-BET 0.3160 0.0316 1.0000
uM
 72
hr
 3 962 632 0.0965 0.0978 0.6570 0.6770
WM-115 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 1 1680 611 0.3125 0.3094 0.3637 0.3523
WM-115 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 2 1641 571 0.3128 0.3094 0.3480 0.3523
WM-115 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 3 1582 546 0.3029 0.3094 0.3451 0.3523
WM-115 Vemurafenib Trametinib I-BET 1.0000 0.1000 1.0000
uM
 72
hr
 1 959 689 0.0789 0.0709 0.7185 0.7196
WM-115 Vemurafenib Trametinib I-BET 1.0000 0.1000 1.0000
uM
 72
hr
 2 908 668 0.0702 0.0709 0.7357 0.7196
WM-115 Vemurafenib Trametinib I-BET 1.0000 0.1000 1.0000
uM
 72
hr
 3 738 520 0.0637 0.0709 0.7046 0.7196
WM-115 Vemurafenib Trametinib I-BET 3.1600 0.3160 0.0000
uM
 72
hr
 1 1385 689 0.2035 0.2088 0.4975 0.4815