Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

 Full screen view
Filter results: >>>>
Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Lapatinib
EGFR/HER2
ErbB
 31.2806 100.0000 100.0000 0.4954 0.7950 0.9113 0.2428 0.7519 0.9066 0.0000 0.2457 1.3492 0.0247 0.0703 0.1302 1.5972 63.5403 100.0000
XRP44X
ELK3
MAPK
 0.7816 1.1482 1.8976 -0.2021 0.0602 0.2789 -0.1369 0.0575 0.2934 1.8769 3.3942 4.9998 0.2905 0.3686 0.4637 0.6561 1.0109 1.3678
FR180204
ERK1/2
MAPK
 56.2203 100.0000 100.0000 0.4862 0.6317 0.8238 -0.1433 0.2500 0.7055 0.0180 0.6403 1.9539 0.0470 0.0722 0.1058 65.9938 100.0000 100.0000
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
PD173074
FGFR1/3
RTK
 7.0478 8.9285 13.6750 -0.8719 -0.6669 -0.2130 -1.0000 -0.9488 -0.5559 1.6563 2.2671 4.5022 0.0991 0.1926 0.2504 8.7381 13.6708 21.0369
Lestaurtinib
FLT3/JAK2/TrkA
RTK
 0.2491 0.7096 1.5478 -0.9565 -0.8762 -0.7290 -1.0000 -1.0000 -0.9202 0.6212 0.8572 1.4388 0.3615 0.4228 0.5481 1.3258 2.5025 5.3389
FTase Inhibitor I
Ftase
MAPK
 100.0000 100.0000 100.0000 0.7715 0.8851 0.9752 0.7468 0.8851 0.9752 0.0000 0.0000 0.0000 0.0099 0.0556 0.0941 100.0000 100.0000 100.0000
Valproic acid
HDAC
HDAC
 100.0000 100.0000 100.0000 -0.8969 -0.6820 -0.4277 -0.5381 -0.3207 -0.1180 1.1443 1.2884 1.4704 0.1935 0.2464 0.2891 100.0000 100.0000 100.0000
LBH589
HDAC
HDAC
 0.0792 0.1432 0.2719 -0.9159 -0.8072 -0.7128 -0.9155 -0.7955 -0.6832 1.1720 1.5004 2.1649 0.5471 0.6739 0.7846 0.1472 0.2600 0.4626
Oxamflatin
HDAC
HDAC
 0.6664 0.9513 1.6592 -0.9525 -0.8858 -0.8199 -1.0000 -0.9857 -0.8929 1.0334 1.2610 1.4776 0.4375 0.5175 0.6006 1.6681 2.6703 3.8183
Trichostatin A
HDAC
HDAC
 6.5374 11.5225 17.5553 -0.9202 -0.8512 -0.7541 -0.9053 -0.8178 -0.6756 1.3647 1.8955 2.2777 0.6490 0.7724 0.9158 11.0302 20.2024 30.2620
Vorinostat
HDAC
HDAC
 72.1503 100.0000 100.0000 -0.8970 -0.8099 -0.5591 -0.9320 -0.8403 -0.5970 1.0273 1.3201 1.6251 0.4794 0.5820 0.7389 100.0000 100.0000 100.0000
Geldanamycin
HSP90
HSP90
 0.0092 0.0240 0.0425 -0.4324 -0.2962 -0.0904 -0.3507 -0.2347 -0.0323 1.6732 2.3748 3.3908 0.6486 0.7709 0.9035 0.0116 0.0269 0.0560
17-AAG
HSP90
HSP90
 0.0442 0.0876 0.1713 -0.7309 -0.6010 -0.3062 -0.5924 -0.4000 -0.2370 0.8987 1.8748 3.3051 0.4754 0.6987 0.8282 0.0680 0.1218 0.3890
GSK1838705A
IGF1R
RTK
 4.0665 10.9435 23.1329 -0.6969 -0.3849 -0.1067 -0.7773 -0.4275 -0.2150 1.5275 2.6721 3.2208 0.2264 0.2964 0.4149 2.6121 7.6760 17.5013
AG1024
IGF1R
RTK
 14.2327 62.8199 100.0000 0.3069 0.5828 0.8614 -0.0340 0.2904 0.6353 0.3280 1.4424 3.0172 0.0186 0.0785 0.1208 8.3409 30.1991 100.0000
PS-1145
IKK
NFKB
 100.0000 100.0000 100.0000 0.8452 0.9304 0.9718 0.8353 0.9304 0.9695 0.0000 0.0000 0.8067 -0.0033 0.0200 0.0533 100.0000 100.0000 100.0000
TPCA-1
IKK
NFKB
 4.9121 23.5816 100.0000 0.0988 0.4346 0.6277 -0.1071 0.3912 0.5674 0.5796 1.2158 2.2892 0.0966 0.1616 0.2244 2.5700 5.7466 43.2238
IKK16
IKK
NFKB
 1.8767 3.1049 3.8519 -0.9668 -0.9445 -0.8619 -0.9890 -0.9578 -0.8641 2.2018 3.4729 4.3592 0.3739 0.4332 0.4763 3.1521 4.0389 4.8853
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
Ispinesib
KSP
Kinesin
 0.0263 0.0439 0.1261 -0.9817 -0.9567 -0.8688 -1.0000 -0.9800 -0.6258 0.4997 1.2912 3.1780 0.5293 0.6720 0.8104 0.0357 0.4315 1.3590
Baicalein
Lipoxygenase
Metabolism
 41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
Nutlin 3a
MDM2
MDM2
 15.2348 24.3890 41.8634 -0.3252 -0.0482 0.2155 -1.0000 -0.8163 -0.2697 1.1456 1.7429 2.5635 0.0828 0.1397 0.2099 23.6810 39.7952 62.9892
PD184352
MEK
MAPK
 31.0822 100.0000 100.0000 0.4258 0.7584 0.9084 -0.2272 0.7139 0.9084 0.0000 0.0524 0.4766 0.0368 0.0888 0.1432 63.7076 100.0000 100.0000