Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Valproic acid
HDAC
HDAC
 100.0000 100.0000 100.0000 -0.8969 -0.6820 -0.4277 -0.5381 -0.3207 -0.1180 1.1443 1.2884 1.4704 0.1935 0.2464 0.2891 100.0000 100.0000 100.0000
Geldanamycin
HSP90
HSP90
 0.0092 0.0240 0.0425 -0.4324 -0.2962 -0.0904 -0.3507 -0.2347 -0.0323 1.6732 2.3748 3.3908 0.6486 0.7709 0.9035 0.0116 0.0269 0.0560
17-AAG
HSP90
HSP90
 0.0442 0.0876 0.1713 -0.7309 -0.6010 -0.3062 -0.5924 -0.4000 -0.2370 0.8987 1.8748 3.3051 0.4754 0.6987 0.8282 0.0680 0.1218 0.3890
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
GSK923295
CENPE
Kinesin
 0.0392 0.0651 0.2250 -0.5702 -0.2653 -0.0001 -0.5044 -0.2084 0.0089 1.0722 2.1595 3.4297 0.3588 0.4764 0.6241 0.0452 0.0615 1.0057
Ispinesib
KSP
Kinesin
 0.0263 0.0439 0.1261 -0.9817 -0.9567 -0.8688 -1.0000 -0.9800 -0.6258 0.4997 1.2912 3.1780 0.5293 0.6720 0.8104 0.0357 0.4315 1.3590
PD 98059
MEK
MAPK
 100.0000 100.0000 100.0000 0.5235 0.6650 0.8191 -0.1517 0.5395 0.8149 0.0000 0.2473 0.7779 0.0463 0.0842 0.1501 32.4005 100.0000 100.0000
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
Selumetinib
MEK
MAPK
 3.4703 100.0000 100.0000 0.2888 0.6993 0.8618 0.1384 0.6524 0.8687 0.0000 0.4990 0.9393 0.0510 0.1233 0.3040 0.3246 2.6951 100.0000
PD184352
MEK
MAPK
 31.0822 100.0000 100.0000 0.4258 0.7584 0.9084 -0.2272 0.7139 0.9084 0.0000 0.0524 0.4766 0.0368 0.0888 0.1432 63.7076 100.0000 100.0000
FTase Inhibitor I
Ftase
MAPK
 100.0000 100.0000 100.0000 0.7715 0.8851 0.9752 0.7468 0.8851 0.9752 0.0000 0.0000 0.0000 0.0099 0.0556 0.0941 100.0000 100.0000 100.0000
FR180204
ERK1/2
MAPK
 56.2203 100.0000 100.0000 0.4862 0.6317 0.8238 -0.1433 0.2500 0.7055 0.0180 0.6403 1.9539 0.0470 0.0722 0.1058 65.9938 100.0000 100.0000
XRP44X
ELK3
MAPK
 0.7816 1.1482 1.8976 -0.2021 0.0602 0.2789 -0.1369 0.0575 0.2934 1.8769 3.3942 4.9998 0.2905 0.3686 0.4637 0.6561 1.0109 1.3678
L-779450
BRAF
MAPK
 12.8318 28.9246 48.0158 -0.2622 0.2749 0.3891 -1.0000 -0.6190 -0.1023 1.0435 1.8204 3.7221 0.0544 0.0922 0.1394 20.7244 44.1580 61.2878
Nutlin 3a
MDM2
MDM2
 15.2348 24.3890 41.8634 -0.3252 -0.0482 0.2155 -1.0000 -0.8163 -0.2697 1.1456 1.7429 2.5635 0.0828 0.1397 0.2099 23.6810 39.7952 62.9892
Baicalein
Lipoxygenase
Metabolism
 41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
SB-3CT
MMP2/9
MMP
 69.9094 100.0000 100.0000 0.4441 0.6795 0.8316 -0.1049 0.6210 0.7846 0.0670 0.6905 2.4960 0.0290 0.0754 0.1306 27.8608 93.1362 100.0000
Everolimus
MTOR
MTOR
 0.0432 0.6717 4.3873 -0.8294 -0.6714 -0.2303 -1.0000 -1.0000 -0.6838 0.2890 0.4230 0.7677 0.3295 0.4415 0.5925 1.5205 9.7227 26.2255
Sirolimus
MTOR
MTOR
 0.0785 2.7199 100.0000 -0.0907 0.1172 0.3521 -0.3854 0.0690 0.4042 0.2746 0.5743 1.0909 0.2471 0.4095 0.5054 0.0261 0.5698 12.7823
Temsirolimus
MTOR
MTOR
 0.1192 1.7003 10.0307 -0.9332 -0.8176 -0.6679 -1.0000 -1.0000 -0.9967 0.2520 0.4363 1.0813 0.3951 0.4933 0.6311 6.4751 18.8586 43.0334
Torkinib
MTOR
MTOR
 0.0008 0.0021 0.0184 -0.5713 -0.3826 -0.2014 -0.6715 -0.4047 -0.1504 0.3324 0.3720 0.5454 0.6694 0.8411 1.0104 0.0046 0.0211 0.0646
Ribavirin
N/A
N/A
 100.0000 100.0000 100.0000 0.6045 0.7146 0.9546 0.4725 0.6701 0.9546 0.0000 0.0000 0.9838 0.0119 0.0416 0.0703 50.4745 100.0000 100.0000
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000