Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 4.8478 | 6.2817 | 9.9436 | -0.9902 | -0.9623 | -0.8818 | -0.9966 | -0.9683 | -0.8864 | 1.4527 | 2.4005 | 3.5359 | 0.3679 | 0.4354 | 0.4695 | 8.0047 | 9.6271 | 12.8243 | |
| MG-132 | Proteasome | Proteasome | 0.1071 | 0.1768 | 0.5078 | -0.8632 | -0.7505 | -0.5413 | -0.8499 | -0.6667 | -0.5123 | 1.5044 | 2.4128 | 3.5768 | 0.6530 | 0.7329 | 0.8677 | 0.1559 | 0.2469 | 1.0059 | |
| GSK1838705A | IGF1R | RTK | 4.0665 | 10.9435 | 23.1329 | -0.6969 | -0.3849 | -0.1067 | -0.7773 | -0.4275 | -0.2150 | 1.5275 | 2.6721 | 3.2208 | 0.2264 | 0.2964 | 0.4149 | 2.6121 | 7.6760 | 17.5013 | |
| Taxol | TUBB | TUBB | 0.0078 | 0.0104 | 0.0155 | -0.5505 | -0.2204 | 0.0319 | -0.5168 | -0.1393 | 0.1113 | 1.6357 | 2.0915 | 3.1238 | 0.5399 | 0.6855 | 0.9358 | 0.0096 | 0.0111 | 0.0153 | |
| Baicalein | Lipoxygenase | Metabolism | 41.6425 | 70.6950 | 100.0000 | -0.0508 | 0.2583 | 0.5386 | -0.5772 | 0.0203 | 0.4255 | 1.6411 | 2.5826 | 3.9209 | 0.0595 | 0.1090 | 0.1450 | 32.6213 | 62.3319 | 100.0000 | |
| PD173074 | FGFR1/3 | RTK | 7.0478 | 8.9285 | 13.6750 | -0.8719 | -0.6669 | -0.2130 | -1.0000 | -0.9488 | -0.5559 | 1.6563 | 2.2671 | 4.5022 | 0.0991 | 0.1926 | 0.2504 | 8.7381 | 13.6708 | 21.0369 | |
| Geldanamycin | HSP90 | HSP90 | 0.0092 | 0.0240 | 0.0425 | -0.4324 | -0.2962 | -0.0904 | -0.3507 | -0.2347 | -0.0323 | 1.6732 | 2.3748 | 3.3908 | 0.6486 | 0.7709 | 0.9035 | 0.0116 | 0.0269 | 0.0560 | |
| Nelfinavir | N/A | N/A | 8.4034 | 9.7440 | 15.4339 | -0.8211 | -0.6445 | -0.2989 | -1.0000 | -1.0000 | -0.8006 | 1.6805 | 2.3548 | 2.7767 | 0.1130 | 0.1589 | 0.1970 | 12.4011 | 15.3815 | 22.7642 | |
| Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.4036 | 0.5478 | 1.0248 | -0.8567 | -0.7928 | -0.6682 | -0.8570 | -0.7958 | -0.6543 | 1.7769 | 2.1873 | 3.5139 | 0.5265 | 0.6392 | 0.6811 | 0.6073 | 0.7378 | 1.6091 | |
| NSC 663284 | CDC25 | CDC | 1.6689 | 2.2519 | 3.0742 | -0.9668 | -0.9336 | -0.8607 | -0.9846 | -0.9413 | -0.8554 | 1.8405 | 2.5456 | 4.2988 | 0.5484 | 0.5805 | 0.6318 | 2.2603 | 3.4718 | 5.7633 | |
| XRP44X | ELK3 | MAPK | 0.7816 | 1.1482 | 1.8976 | -0.2021 | 0.0602 | 0.2789 | -0.1369 | 0.0575 | 0.2934 | 1.8769 | 3.3942 | 4.9998 | 0.2905 | 0.3686 | 0.4637 | 0.6561 | 1.0109 | 1.3678 | |
| Fascaplysin | CDK4 | CDK | 0.1734 | 0.2805 | 0.3987 | -0.9809 | -0.9546 | -0.8701 | -0.9898 | -0.9538 | -0.8570 | 1.9348 | 2.3235 | 2.8230 | 0.5843 | 0.6643 | 0.7626 | 0.3281 | 0.4110 | 0.6267 | |
| IKK16 | IKK | NFKB | 1.8767 | 3.1049 | 3.8519 | -0.9668 | -0.9445 | -0.8619 | -0.9890 | -0.9578 | -0.8641 | 2.2018 | 3.4729 | 4.3592 | 0.3739 | 0.4332 | 0.4763 | 3.1521 | 4.0389 | 4.8853 | |
| Imatinib | ABL/KIT/PDGFR | nRTK | 18.5481 | 21.7914 | 25.5570 | -0.9852 | -0.9632 | -0.8948 | -0.9969 | -0.9814 | -0.8936 | 2.2328 | 2.7060 | 3.3541 | 0.3997 | 0.4467 | 0.4851 | 27.9144 | 31.9309 | 36.9254 | |
| GSK461364 | PLK1 | PLK | 0.0087 | 0.0183 | 0.0805 | -0.6111 | -0.4222 | -0.2111 | -0.4745 | -0.3080 | -0.0919 | 2.4728 | 2.7172 | 4.9263 | 0.4701 | 0.6125 | 0.7345 | 0.0105 | 0.0265 | 0.3325 |