Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Docetaxel
TUBB
TUBB
 0.0022 0.0051 0.0098 -0.3944 -0.0464 0.1697 -0.4257 -0.0477 0.1373 1.4024 1.6746 2.3040 0.4979 0.6215 0.8198 0.0027 0.0049 0.0080
Nutlin 3a
MDM2
MDM2
 15.2348 24.3890 41.8634 -0.3252 -0.0482 0.2155 -1.0000 -0.8163 -0.2697 1.1456 1.7429 2.5635 0.0828 0.1397 0.2099 23.6810 39.7952 62.9892
Pevonedistat
NAE1
NAE1
 0.1439 0.3445 1.2615 -0.3074 -0.0880 0.0407 -0.4612 -0.1540 0.0480 0.6476 0.9529 1.4328 0.3433 0.4344 0.5442 0.1672 0.7014 1.4696
Gefitinib
EGFR
ErbB
 6.6704 12.9191 28.3915 -0.2671 0.0424 0.3018 -0.8465 -0.5620 -0.2259 0.9170 1.3719 2.5436 0.0767 0.1382 0.2408 9.0805 26.2291 41.5832
L-779450
BRAF
MAPK
 12.8318 28.9246 48.0158 -0.2622 0.2749 0.3891 -1.0000 -0.6190 -0.1023 1.0435 1.8204 3.7221 0.0544 0.0922 0.1394 20.7244 44.1580 61.2878
Triciribine
AKT
AKT
 0.1497 1.0069 10.2321 -0.2208 0.0730 0.3595 -0.6783 -0.3270 0.0049 0.3693 0.5173 0.9769 0.1961 0.3180 0.4712 0.2958 1.3169 18.2553
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
XRP44X
ELK3
MAPK
 0.7816 1.1482 1.8976 -0.2021 0.0602 0.2789 -0.1369 0.0575 0.2934 1.8769 3.3942 4.9998 0.2905 0.3686 0.4637 0.6561 1.0109 1.3678
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
Gemcitabine
DNA replication
DNA replication
 0.0255 0.1767 1.3221 -0.1534 0.1060 0.2747 -0.1430 0.1441 0.3026 0.5558 1.2204 2.6334 0.3723 0.5392 0.7460 0.0153 0.0741 0.2614
Sirolimus
MTOR
MTOR
 0.0785 2.7199 100.0000 -0.0907 0.1172 0.3521 -0.3854 0.0690 0.4042 0.2746 0.5743 1.0909 0.2471 0.4095 0.5054 0.0261 0.5698 12.7823
AG1478
EGFR
ErbB
 8.7673 51.6075 100.0000 -0.0710 0.2684 0.6341 -0.3109 -0.0273 0.4206 0.8939 1.7205 2.6373 0.0902 0.1531 0.2936 3.7212 36.6666 94.4655
Baicalein
Lipoxygenase
Metabolism
 41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
ZM-447439
AURK
AURK
 3.5193 19.1991 100.0000 -0.0403 0.4141 0.5578 -0.1176 0.3301 0.5652 0.5578 1.0337 2.9596 0.1428 0.2012 0.3024 0.6732 2.5837 16.4745
Erlotinib
EGFR
ErbB
 6.4716 35.2468 100.0000 0.0317 0.4006 0.6354 -0.8374 -0.1704 0.3788 0.3155 0.7139 1.8126 0.0351 0.1228 0.2396 13.2839 41.2968 100.0000
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
Purvalanol A
CDK1
CDK
 25.2896 54.7310 100.0000 0.0757 0.5333 0.7416 -0.0675 0.5068 0.7450 1.0817 2.5000 4.2404 0.0335 0.0774 0.1767 18.1854 35.4887 52.3768
TPCA-1
IKK
NFKB
 4.9121 23.5816 100.0000 0.0988 0.4346 0.6277 -0.1071 0.3912 0.5674 0.5796 1.2158 2.2892 0.0966 0.1616 0.2244 2.5700 5.7466 43.2238
Dactolisib
PI3K
PI3K
 0.1885 0.5181 100.0000 0.2549 0.5042 0.6208 0.2262 0.4314 0.5885 0.0000 2.2633 4.9147 0.2133 0.2744 0.3494 0.1148 0.3521 100.0000
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
AS-252424
PI3K
PI3K
 19.5544 36.2256 100.0000 0.2865 0.4240 0.5918 -0.9991 0.2157 0.5619 0.3148 0.6846 2.7243 0.0770 0.1059 0.1601 6.6689 89.5846 100.0000
Selumetinib
MEK
MAPK
 3.4703 100.0000 100.0000 0.2888 0.6993 0.8618 0.1384 0.6524 0.8687 0.0000 0.4990 0.9393 0.0510 0.1233 0.3040 0.3246 2.6951 100.0000
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000