Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AG1478 | EGFR | ErbB | 8.7673 | 51.6075 | 100.0000 | -0.0710 | 0.2684 | 0.6341 | -0.3109 | -0.0273 | 0.4206 | 0.8939 | 1.7205 | 2.6373 | 0.0902 | 0.1531 | 0.2936 | 3.7212 | 36.6666 | 94.4655 | |
| (Z)-4-Hydroxytamoxifen | ESR1 | N/A | 38.2142 | 72.1652 | 100.0000 | -0.2149 | 0.3051 | 0.6418 | -0.8145 | -0.0997 | 0.5442 | 0.6236 | 1.8012 | 2.9451 | 0.0928 | 0.1395 | 0.2253 | 17.7725 | 43.7586 | 100.0000 | |
| TPCA-1 | IKK | NFKB | 4.9121 | 23.5816 | 100.0000 | 0.0988 | 0.4346 | 0.6277 | -0.1071 | 0.3912 | 0.5674 | 0.5796 | 1.2158 | 2.2892 | 0.0966 | 0.1616 | 0.2244 | 2.5700 | 5.7466 | 43.2238 | |
| JNK-IN-5A | JNK | JNK | 1.8491 | 14.2132 | 100.0000 | -0.1818 | 0.1302 | 0.4971 | -0.4099 | 0.0435 | 0.4984 | 0.0000 | 3.1821 | 4.9999 | 0.0989 | 0.2367 | 0.3549 | 1.4898 | 12.5032 | 100.0000 | |
| PD173074 | FGFR1/3 | RTK | 7.0478 | 8.9285 | 13.6750 | -0.8719 | -0.6669 | -0.2130 | -1.0000 | -0.9488 | -0.5559 | 1.6563 | 2.2671 | 4.5022 | 0.0991 | 0.1926 | 0.2504 | 8.7381 | 13.6708 | 21.0369 | |
| Nelfinavir | N/A | N/A | 8.4034 | 9.7440 | 15.4339 | -0.8211 | -0.6445 | -0.2989 | -1.0000 | -1.0000 | -0.8006 | 1.6805 | 2.3548 | 2.7767 | 0.1130 | 0.1589 | 0.1970 | 12.4011 | 15.3815 | 22.7642 | |
| ICRF-193 | TOP2 | TOP | 8.5852 | 100.0000 | 100.0000 | 0.3561 | 0.5910 | 0.6710 | 0.2252 | 0.4446 | 0.6698 | 0.1440 | 0.6745 | 1.5658 | 0.1152 | 0.1622 | 0.2393 | 0.3708 | 3.7956 | 100.0000 | |
| NU6102 | CDK1/2 | CDK | 12.2242 | 17.3275 | 31.6450 | -0.7759 | -0.4783 | -0.1439 | -1.0000 | -0.9972 | -0.6085 | 1.3221 | 1.8051 | 3.6950 | 0.1178 | 0.1554 | 0.2440 | 20.2928 | 27.4520 | 55.8294 | |
| CPT-11 | TOP1 | TOP | 3.1544 | 10.7270 | 20.8553 | -0.5980 | -0.2192 | 0.1666 | -0.9688 | -0.6234 | -0.1292 | 0.8799 | 1.3528 | 1.8883 | 0.1220 | 0.2195 | 0.2928 | 7.3583 | 23.7091 | 36.8667 | |
| Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 36.5873 | 68.4588 | 100.0000 | -0.7737 | -0.2023 | 0.2203 | -0.7439 | -0.3900 | 0.2345 | 0.6570 | 1.9429 | 3.4993 | 0.1339 | 0.2188 | 0.2978 | 54.8881 | 71.4700 | 100.0000 | |
| ZM-447439 | AURK | AURK | 3.5193 | 19.1991 | 100.0000 | -0.0403 | 0.4141 | 0.5578 | -0.1176 | 0.3301 | 0.5652 | 0.5578 | 1.0337 | 2.9596 | 0.1428 | 0.2012 | 0.3024 | 0.6732 | 2.5837 | 16.4745 | |
| Disulfiram | Proteasome | Proteasome | 0.2148 | 13.4616 | 100.0000 | -0.6139 | 0.0054 | 0.4486 | -0.9836 | -0.0088 | 0.5061 | 0.2242 | 2.0208 | 4.9998 | 0.1469 | 0.2459 | 0.3654 | 0.1623 | 16.2617 | 100.0000 | |
| Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.9523 | 4.3787 | 11.8540 | -0.5661 | -0.3376 | -0.0359 | -1.0000 | -1.0000 | -0.4350 | 0.4858 | 0.8218 | 1.3502 | 0.1794 | 0.3014 | 0.3656 | 4.7346 | 16.5294 | 34.8041 | |
| Valproic acid | HDAC | HDAC | 100.0000 | 100.0000 | 100.0000 | -0.8969 | -0.6820 | -0.4277 | -0.5381 | -0.3207 | -0.1180 | 1.1443 | 1.2884 | 1.4704 | 0.1935 | 0.2464 | 0.2891 | 100.0000 | 100.0000 | 100.0000 | |
| Triciribine | AKT | AKT | 0.1497 | 1.0069 | 10.2321 | -0.2208 | 0.0730 | 0.3595 | -0.6783 | -0.3270 | 0.0049 | 0.3693 | 0.5173 | 0.9769 | 0.1961 | 0.3180 | 0.4712 | 0.2958 | 1.3169 | 18.2553 | |
| Ibandronate | FDPS | N/A | 49.3295 | 82.7741 | 100.0000 | -0.5209 | -0.1213 | 0.0387 | -0.7048 | -0.2169 | -0.0113 | 0.9599 | 1.4483 | 1.9155 | 0.2062 | 0.2750 | 0.3199 | 66.6332 | 98.6899 | 100.0000 | |
| GSK1070916 | AURK | AURK | 0.6046 | 3.0981 | 6.6549 | -0.8474 | -0.6391 | -0.3610 | -1.0000 | -1.0000 | -0.9999 | 0.6499 | 0.9902 | 1.5949 | 0.2113 | 0.2924 | 0.4314 | 3.5405 | 8.2453 | 15.6107 | |
| Dactolisib | PI3K | PI3K | 0.1885 | 0.5181 | 100.0000 | 0.2549 | 0.5042 | 0.6208 | 0.2262 | 0.4314 | 0.5885 | 0.0000 | 2.2633 | 4.9147 | 0.2133 | 0.2744 | 0.3494 | 0.1148 | 0.3521 | 100.0000 | |
| GSK1838705A | IGF1R | RTK | 4.0665 | 10.9435 | 23.1329 | -0.6969 | -0.3849 | -0.1067 | -0.7773 | -0.4275 | -0.2150 | 1.5275 | 2.6721 | 3.2208 | 0.2264 | 0.2964 | 0.4149 | 2.6121 | 7.6760 | 17.5013 | |
| Sigma A6730 | AKT | AKT | 2.0327 | 6.5660 | 11.2198 | -0.9178 | -0.8320 | -0.6777 | -1.0000 | -1.0000 | -0.9546 | 0.9310 | 1.3794 | 2.0044 | 0.2439 | 0.2875 | 0.4042 | 6.3004 | 13.6236 | 19.0461 | |
| Sirolimus | MTOR | MTOR | 0.0785 | 2.7199 | 100.0000 | -0.0907 | 0.1172 | 0.3521 | -0.3854 | 0.0690 | 0.4042 | 0.2746 | 0.5743 | 1.0909 | 0.2471 | 0.4095 | 0.5054 | 0.0261 | 0.5698 | 12.7823 | |
| Olomoucine II | CDK1 | CDK | 3.7444 | 6.0358 | 7.3956 | -0.7023 | -0.3927 | -0.1441 | -0.7230 | -0.4357 | -0.1137 | 1.4260 | 2.7083 | 4.7257 | 0.2563 | 0.3202 | 0.3981 | 5.9885 | 7.0813 | 8.6384 | |
| 5-DFUR | TYMS | TYMS | 68.5295 | 100.0000 | 100.0000 | -0.1871 | -0.0208 | 0.0399 | -0.5625 | -0.3158 | -0.1425 | 0.3943 | 0.5084 | 0.6195 | 0.2584 | 0.3100 | 0.3856 | 100.0000 | 100.0000 | 100.0000 | |
| Carboplatin | DNA cross-linker | DNA cross-linker | 30.4522 | 52.4276 | 91.0569 | -0.9081 | -0.7672 | -0.5844 | -0.9460 | -0.8644 | -0.7390 | 1.2433 | 1.6402 | 2.1619 | 0.2714 | 0.3706 | 0.4859 | 52.1319 | 91.7409 | 100.0000 | |
| Cisplatin | DNA cross-linker | DNA cross-linker | 4.4823 | 11.6380 | 25.2438 | -0.8850 | -0.6449 | -0.2565 | -0.9047 | -0.5931 | -0.2921 | 1.0217 | 1.3698 | 2.2177 | 0.2715 | 0.3752 | 0.4391 | 8.7984 | 21.1543 | 38.4325 |