Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

 Full screen view
Filter results: >>>>
Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Topotecan
TOP1
TOP
 0.0324 0.1223 0.4672 -0.7615 -0.5906 -0.2740 -0.8265 -0.6901 -0.4582 0.5573 0.7931 1.1373 0.5801 0.7088 0.8375 0.0774 0.7078 1.2170
Gemcitabine
DNA replication
DNA replication
 0.0255 0.1767 1.3221 -0.1534 0.1060 0.2747 -0.1430 0.1441 0.3026 0.5558 1.2204 2.6334 0.3723 0.5392 0.7460 0.0153 0.0741 0.2614
Etoposide
TOP2
TOP
 1.1610 2.9708 7.6285 -0.6938 -0.4841 -0.2079 -0.7406 -0.5842 -0.4690 0.5531 0.8108 1.2247 0.3770 0.4769 0.5711 4.4274 7.6731 19.6965
5-FU
TYMS
TYMS
 43.5628 98.8715 100.0000 -0.6126 -0.4736 -0.0711 -0.8532 -0.6532 -0.1200 0.5225 0.5967 0.7832 0.3295 0.4853 0.6100 100.0000 100.0000 100.0000
Afatinib
EGFR/HER2
ErbB
 0.1253 1.5517 2.4757 -0.9553 -0.9200 -0.8460 -1.0000 -1.0000 -0.9391 0.5080 1.0283 1.7263 0.4620 0.5435 0.6679 1.1116 3.3143 4.9447
Ispinesib
KSP
Kinesin
 0.0263 0.0439 0.1261 -0.9817 -0.9567 -0.8688 -1.0000 -0.9800 -0.6258 0.4997 1.2912 3.1780 0.5293 0.6720 0.8104 0.0357 0.4315 1.3590
Tozasertib
AURK/FLT3/ABL/JAK2
AURK
 0.9523 4.3787 11.8540 -0.5661 -0.3376 -0.0359 -1.0000 -1.0000 -0.4350 0.4858 0.8218 1.3502 0.1794 0.3014 0.3656 4.7346 16.5294 34.8041
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
CGC-11047
Polyamine analogue
N/A
 43.1451 85.4630 100.0000 -0.8722 -0.7234 -0.2437 -1.0000 -0.9172 -0.4365 0.4134 0.5735 1.1488 0.3172 0.3971 0.4905 94.6485 100.0000 100.0000
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
Ixabepilone
TUBB
TUBB
 0.0045 0.0114 0.0487 -0.9765 -0.9460 -0.8485 -0.9892 -0.7196 -0.5742 0.3937 0.7623 1.6684 0.6842 0.8505 0.9658 0.0102 0.0892 0.7025
Vinorelbine
TUBB
TUBB
 0.0079 0.0130 0.0470 -0.9358 -0.8653 -0.6758 -1.0000 -0.5683 -0.3360 0.3815 2.2644 3.6055 0.6197 0.8320 1.0409 0.0132 0.0302 0.9743
Triciribine
AKT
AKT
 0.1497 1.0069 10.2321 -0.2208 0.0730 0.3595 -0.6783 -0.3270 0.0049 0.3693 0.5173 0.9769 0.1961 0.3180 0.4712 0.2958 1.3169 18.2553
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
Torkinib
MTOR
MTOR
 0.0008 0.0021 0.0184 -0.5713 -0.3826 -0.2014 -0.6715 -0.4047 -0.1504 0.3324 0.3720 0.5454 0.6694 0.8411 1.0104 0.0046 0.0211 0.0646
AG1024
IGF1R
RTK
 14.2327 62.8199 100.0000 0.3069 0.5828 0.8614 -0.0340 0.2904 0.6353 0.3280 1.4424 3.0172 0.0186 0.0785 0.1208 8.3409 30.1991 100.0000
Erlotinib
EGFR
ErbB
 6.4716 35.2468 100.0000 0.0317 0.4006 0.6354 -0.8374 -0.1704 0.3788 0.3155 0.7139 1.8126 0.0351 0.1228 0.2396 13.2839 41.2968 100.0000
AS-252424
PI3K
PI3K
 19.5544 36.2256 100.0000 0.2865 0.4240 0.5918 -0.9991 0.2157 0.5619 0.3148 0.6846 2.7243 0.0770 0.1059 0.1601 6.6689 89.5846 100.0000
Everolimus
MTOR
MTOR
 0.0432 0.6717 4.3873 -0.8294 -0.6714 -0.2303 -1.0000 -1.0000 -0.6838 0.2890 0.4230 0.7677 0.3295 0.4415 0.5925 1.5205 9.7227 26.2255
Sirolimus
MTOR
MTOR
 0.0785 2.7199 100.0000 -0.0907 0.1172 0.3521 -0.3854 0.0690 0.4042 0.2746 0.5743 1.0909 0.2471 0.4095 0.5054 0.0261 0.5698 12.7823
Temsirolimus
MTOR
MTOR
 0.1192 1.7003 10.0307 -0.9332 -0.8176 -0.6679 -1.0000 -1.0000 -0.9967 0.2520 0.4363 1.0813 0.3951 0.4933 0.6311 6.4751 18.8586 43.0334
Disulfiram
Proteasome
Proteasome
 0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000
ICRF-193
TOP2
TOP
 8.5852 100.0000 100.0000 0.3561 0.5910 0.6710 0.2252 0.4446 0.6698 0.1440 0.6745 1.5658 0.1152 0.1622 0.2393 0.3708 3.7956 100.0000
SB-3CT
MMP2/9
MMP
 69.9094 100.0000 100.0000 0.4441 0.6795 0.8316 -0.1049 0.6210 0.7846 0.0670 0.6905 2.4960 0.0290 0.0754 0.1306 27.8608 93.1362 100.0000
FR180204
ERK1/2
MAPK
 56.2203 100.0000 100.0000 0.4862 0.6317 0.8238 -0.1433 0.2500 0.7055 0.0180 0.6403 1.9539 0.0470 0.0722 0.1058 65.9938 100.0000 100.0000