Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Baicalein
Lipoxygenase
Metabolism
 41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
AG1478
EGFR
ErbB
 8.7673 51.6075 100.0000 -0.0710 0.2684 0.6341 -0.3109 -0.0273 0.4206 0.8939 1.7205 2.6373 0.0902 0.1531 0.2936 3.7212 36.6666 94.4655
Sirolimus
MTOR
MTOR
 0.0785 2.7199 100.0000 -0.0907 0.1172 0.3521 -0.3854 0.0690 0.4042 0.2746 0.5743 1.0909 0.2471 0.4095 0.5054 0.0261 0.5698 12.7823
Gemcitabine
DNA replication
DNA replication
 0.0255 0.1767 1.3221 -0.1534 0.1060 0.2747 -0.1430 0.1441 0.3026 0.5558 1.2204 2.6334 0.3723 0.5392 0.7460 0.0153 0.0741 0.2614
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
XRP44X
ELK3
MAPK
 0.7816 1.1482 1.8976 -0.2021 0.0602 0.2789 -0.1369 0.0575 0.2934 1.8769 3.3942 4.9998 0.2905 0.3686 0.4637 0.6561 1.0109 1.3678
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Triciribine
AKT
AKT
 0.1497 1.0069 10.2321 -0.2208 0.0730 0.3595 -0.6783 -0.3270 0.0049 0.3693 0.5173 0.9769 0.1961 0.3180 0.4712 0.2958 1.3169 18.2553
L-779450
BRAF
MAPK
 12.8318 28.9246 48.0158 -0.2622 0.2749 0.3891 -1.0000 -0.6190 -0.1023 1.0435 1.8204 3.7221 0.0544 0.0922 0.1394 20.7244 44.1580 61.2878
Gefitinib
EGFR
ErbB
 6.6704 12.9191 28.3915 -0.2671 0.0424 0.3018 -0.8465 -0.5620 -0.2259 0.9170 1.3719 2.5436 0.0767 0.1382 0.2408 9.0805 26.2291 41.5832
Pevonedistat
NAE1
NAE1
 0.1439 0.3445 1.2615 -0.3074 -0.0880 0.0407 -0.4612 -0.1540 0.0480 0.6476 0.9529 1.4328 0.3433 0.4344 0.5442 0.1672 0.7014 1.4696
Nutlin 3a
MDM2
MDM2
 15.2348 24.3890 41.8634 -0.3252 -0.0482 0.2155 -1.0000 -0.8163 -0.2697 1.1456 1.7429 2.5635 0.0828 0.1397 0.2099 23.6810 39.7952 62.9892
Docetaxel
TUBB
TUBB
 0.0022 0.0051 0.0098 -0.3944 -0.0464 0.1697 -0.4257 -0.0477 0.1373 1.4024 1.6746 2.3040 0.4979 0.6215 0.8198 0.0027 0.0049 0.0080
Geldanamycin
HSP90
HSP90
 0.0092 0.0240 0.0425 -0.4324 -0.2962 -0.0904 -0.3507 -0.2347 -0.0323 1.6732 2.3748 3.3908 0.6486 0.7709 0.9035 0.0116 0.0269 0.0560
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
Taxol
TUBB
TUBB
 0.0078 0.0104 0.0155 -0.5505 -0.2204 0.0319 -0.5168 -0.1393 0.1113 1.6357 2.0915 3.1238 0.5399 0.6855 0.9358 0.0096 0.0111 0.0153
Tozasertib
AURK/FLT3/ABL/JAK2
AURK
 0.9523 4.3787 11.8540 -0.5661 -0.3376 -0.0359 -1.0000 -1.0000 -0.4350 0.4858 0.8218 1.3502 0.1794 0.3014 0.3656 4.7346 16.5294 34.8041
GSK923295
CENPE
Kinesin
 0.0392 0.0651 0.2250 -0.5702 -0.2653 -0.0001 -0.5044 -0.2084 0.0089 1.0722 2.1595 3.4297 0.3588 0.4764 0.6241 0.0452 0.0615 1.0057
Torkinib
MTOR
MTOR
 0.0008 0.0021 0.0184 -0.5713 -0.3826 -0.2014 -0.6715 -0.4047 -0.1504 0.3324 0.3720 0.5454 0.6694 0.8411 1.0104 0.0046 0.0211 0.0646
CPT-11
TOP1
TOP
 3.1544 10.7270 20.8553 -0.5980 -0.2192 0.1666 -0.9688 -0.6234 -0.1292 0.8799 1.3528 1.8883 0.1220 0.2195 0.2928 7.3583 23.7091 36.8667
GSK461364
PLK1
PLK
 0.0087 0.0183 0.0805 -0.6111 -0.4222 -0.2111 -0.4745 -0.3080 -0.0919 2.4728 2.7172 4.9263 0.4701 0.6125 0.7345 0.0105 0.0265 0.3325
5-FU
TYMS
TYMS
 43.5628 98.8715 100.0000 -0.6126 -0.4736 -0.0711 -0.8532 -0.6532 -0.1200 0.5225 0.5967 0.7832 0.3295 0.4853 0.6100 100.0000 100.0000 100.0000
Disulfiram
Proteasome
Proteasome
 0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000