Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
XRP44X
ELK3
MAPK
 0.7816 1.1482 1.8976 -0.2021 0.0602 0.2789 -0.1369 0.0575 0.2934 1.8769 3.3942 4.9998 0.2905 0.3686 0.4637 0.6561 1.0109 1.3678
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
Baicalein
Lipoxygenase
Metabolism
 41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
Disulfiram
Proteasome
Proteasome
 0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000
AG1478
EGFR
ErbB
 8.7673 51.6075 100.0000 -0.0710 0.2684 0.6341 -0.3109 -0.0273 0.4206 0.8939 1.7205 2.6373 0.0902 0.1531 0.2936 3.7212 36.6666 94.4655
Docetaxel
TUBB
TUBB
 0.0022 0.0051 0.0098 -0.3944 -0.0464 0.1697 -0.4257 -0.0477 0.1373 1.4024 1.6746 2.3040 0.4979 0.6215 0.8198 0.0027 0.0049 0.0080
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
Taxol
TUBB
TUBB
 0.0078 0.0104 0.0155 -0.5505 -0.2204 0.0319 -0.5168 -0.1393 0.1113 1.6357 2.0915 3.1238 0.5399 0.6855 0.9358 0.0096 0.0111 0.0153
Pevonedistat
NAE1
NAE1
 0.1439 0.3445 1.2615 -0.3074 -0.0880 0.0407 -0.4612 -0.1540 0.0480 0.6476 0.9529 1.4328 0.3433 0.4344 0.5442 0.1672 0.7014 1.4696
Erlotinib
EGFR
ErbB
 6.4716 35.2468 100.0000 0.0317 0.4006 0.6354 -0.8374 -0.1704 0.3788 0.3155 0.7139 1.8126 0.0351 0.1228 0.2396 13.2839 41.2968 100.0000
GSK923295
CENPE
Kinesin
 0.0392 0.0651 0.2250 -0.5702 -0.2653 -0.0001 -0.5044 -0.2084 0.0089 1.0722 2.1595 3.4297 0.3588 0.4764 0.6241 0.0452 0.0615 1.0057
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
Geldanamycin
HSP90
HSP90
 0.0092 0.0240 0.0425 -0.4324 -0.2962 -0.0904 -0.3507 -0.2347 -0.0323 1.6732 2.3748 3.3908 0.6486 0.7709 0.9035 0.0116 0.0269 0.0560
GSK461364
PLK1
PLK
 0.0087 0.0183 0.0805 -0.6111 -0.4222 -0.2111 -0.4745 -0.3080 -0.0919 2.4728 2.7172 4.9263 0.4701 0.6125 0.7345 0.0105 0.0265 0.3325
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
Valproic acid
HDAC
HDAC
 100.0000 100.0000 100.0000 -0.8969 -0.6820 -0.4277 -0.5381 -0.3207 -0.1180 1.1443 1.2884 1.4704 0.1935 0.2464 0.2891 100.0000 100.0000 100.0000
Triciribine
AKT
AKT
 0.1497 1.0069 10.2321 -0.2208 0.0730 0.3595 -0.6783 -0.3270 0.0049 0.3693 0.5173 0.9769 0.1961 0.3180 0.4712 0.2958 1.3169 18.2553
Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
 36.5873 68.4588 100.0000 -0.7737 -0.2023 0.2203 -0.7439 -0.3900 0.2345 0.6570 1.9429 3.4993 0.1339 0.2188 0.2978 54.8881 71.4700 100.0000
17-AAG
HSP90
HSP90
 0.0442 0.0876 0.1713 -0.7309 -0.6010 -0.3062 -0.5924 -0.4000 -0.2370 0.8987 1.8748 3.3051 0.4754 0.6987 0.8282 0.0680 0.1218 0.3890
Torkinib
MTOR
MTOR
 0.0008 0.0021 0.0184 -0.5713 -0.3826 -0.2014 -0.6715 -0.4047 -0.1504 0.3324 0.3720 0.5454 0.6694 0.8411 1.0104 0.0046 0.0211 0.0646
GSK1838705A
IGF1R
RTK
 4.0665 10.9435 23.1329 -0.6969 -0.3849 -0.1067 -0.7773 -0.4275 -0.2150 1.5275 2.6721 3.2208 0.2264 0.2964 0.4149 2.6121 7.6760 17.5013
Olomoucine II
CDK1
CDK
 3.7444 6.0358 7.3956 -0.7023 -0.3927 -0.1441 -0.7230 -0.4357 -0.1137 1.4260 2.7083 4.7257 0.2563 0.3202 0.3981 5.9885 7.0813 8.6384
Bosutinib
Src
nRTK
 1.2187 1.7497 4.1420 -0.6727 -0.4219 -0.1512 -0.7662 -0.4684 -0.1288 0.9612 1.6575 1.9534 0.3079 0.3819 0.4639 1.7722 2.5602 5.3523