Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gemcitabine | DNA replication | DNA replication | 0.0255 | 0.1767 | 1.3221 | -0.1534 | 0.1060 | 0.2747 | -0.1430 | 0.1441 | 0.3026 | 0.5558 | 1.2204 | 2.6334 | 0.3723 | 0.5392 | 0.7460 | 0.0153 | 0.0741 | 0.2614 | |
| LBH589 | HDAC | HDAC | 0.0792 | 0.1432 | 0.2719 | -0.9159 | -0.8072 | -0.7128 | -0.9155 | -0.7955 | -0.6832 | 1.1720 | 1.5004 | 2.1649 | 0.5471 | 0.6739 | 0.7846 | 0.1472 | 0.2600 | 0.4626 | |
| Topotecan | TOP1 | TOP | 0.0324 | 0.1223 | 0.4672 | -0.7615 | -0.5906 | -0.2740 | -0.8265 | -0.6901 | -0.4582 | 0.5573 | 0.7931 | 1.1373 | 0.5801 | 0.7088 | 0.8375 | 0.0774 | 0.7078 | 1.2170 | |
| 17-AAG | HSP90 | HSP90 | 0.0442 | 0.0876 | 0.1713 | -0.7309 | -0.6010 | -0.3062 | -0.5924 | -0.4000 | -0.2370 | 0.8987 | 1.8748 | 3.3051 | 0.4754 | 0.6987 | 0.8282 | 0.0680 | 0.1218 | 0.3890 | |
| GSK923295 | CENPE | Kinesin | 0.0392 | 0.0651 | 0.2250 | -0.5702 | -0.2653 | -0.0001 | -0.5044 | -0.2084 | 0.0089 | 1.0722 | 2.1595 | 3.4297 | 0.3588 | 0.4764 | 0.6241 | 0.0452 | 0.0615 | 1.0057 | |
| Ispinesib | KSP | Kinesin | 0.0263 | 0.0439 | 0.1261 | -0.9817 | -0.9567 | -0.8688 | -1.0000 | -0.9800 | -0.6258 | 0.4997 | 1.2912 | 3.1780 | 0.5293 | 0.6720 | 0.8104 | 0.0357 | 0.4315 | 1.3590 | |
| Bortezomib | Proteasome | Proteasome | 0.0169 | 0.0283 | 0.0758 | -0.9074 | -0.8026 | -0.7299 | -0.9162 | -0.8011 | -0.7357 | 1.1703 | 1.8347 | 2.7508 | 0.9093 | 1.0406 | 1.1781 | 0.0266 | 0.0496 | 0.1485 | |
| Geldanamycin | HSP90 | HSP90 | 0.0092 | 0.0240 | 0.0425 | -0.4324 | -0.2962 | -0.0904 | -0.3507 | -0.2347 | -0.0323 | 1.6732 | 2.3748 | 3.3908 | 0.6486 | 0.7709 | 0.9035 | 0.0116 | 0.0269 | 0.0560 | |
| GSK461364 | PLK1 | PLK | 0.0087 | 0.0183 | 0.0805 | -0.6111 | -0.4222 | -0.2111 | -0.4745 | -0.3080 | -0.0919 | 2.4728 | 2.7172 | 4.9263 | 0.4701 | 0.6125 | 0.7345 | 0.0105 | 0.0265 | 0.3325 | |
| Omipalisib | PI3K | PI3K | 0.0049 | 0.0154 | 0.0397 | -0.8281 | -0.5752 | -0.4164 | -0.8004 | -0.5070 | -0.2908 | 0.6200 | 0.7592 | 0.9464 | 0.6332 | 0.8101 | 0.9689 | 0.0158 | 0.0370 | 0.0945 | |
| Vinorelbine | TUBB | TUBB | 0.0079 | 0.0130 | 0.0470 | -0.9358 | -0.8653 | -0.6758 | -1.0000 | -0.5683 | -0.3360 | 0.3815 | 2.2644 | 3.6055 | 0.6197 | 0.8320 | 1.0409 | 0.0132 | 0.0302 | 0.9743 | |
| Ixabepilone | TUBB | TUBB | 0.0045 | 0.0114 | 0.0487 | -0.9765 | -0.9460 | -0.8485 | -0.9892 | -0.7196 | -0.5742 | 0.3937 | 0.7623 | 1.6684 | 0.6842 | 0.8505 | 0.9658 | 0.0102 | 0.0892 | 0.7025 | |
| Taxol | TUBB | TUBB | 0.0078 | 0.0104 | 0.0155 | -0.5505 | -0.2204 | 0.0319 | -0.5168 | -0.1393 | 0.1113 | 1.6357 | 2.0915 | 3.1238 | 0.5399 | 0.6855 | 0.9358 | 0.0096 | 0.0111 | 0.0153 | |
| Docetaxel | TUBB | TUBB | 0.0022 | 0.0051 | 0.0098 | -0.3944 | -0.0464 | 0.1697 | -0.4257 | -0.0477 | 0.1373 | 1.4024 | 1.6746 | 2.3040 | 0.4979 | 0.6215 | 0.8198 | 0.0027 | 0.0049 | 0.0080 | |
| Torkinib | MTOR | MTOR | 0.0008 | 0.0021 | 0.0184 | -0.5713 | -0.3826 | -0.2014 | -0.6715 | -0.4047 | -0.1504 | 0.3324 | 0.3720 | 0.5454 | 0.6694 | 0.8411 | 1.0104 | 0.0046 | 0.0211 | 0.0646 |