Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7814.016 | uM | 86.84590 | 1000.00000 | 0.3508 | -0.6755 | 0.3498 | 0.1708 | 0.7839 | 0.8623 | ||
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7815.016 | uM | 47.30110 | 203.97620 | 0.0252 | -1.0000 | 0.7517 | 0.1275 | 0.9086 | 0.4370 | ||
| BT-474 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 5905.096 | uM | 63.96990 | 112.68570 | 0.6808 | -0.3704 | 0.9791 | 0.0316 | 0.8092 | 0.9091 | ||
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7816.016 | uM | 39.77890 | 185.42730 | -0.0051 | -1.0000 | 0.7137 | 0.1857 | 0.9465 | 1.1183 | ||
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7813.016 | uM | 38.11570 | 46.84880 | -0.8358 | -0.8400 | 4.7784 | 0.1276 | 0.9950 | 0.8531 | ||
| AU565 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 10880.15 | uM | 9.07190 | 75.67630 | 0.2009 | -1.0000 | 0.5179 | 0.1669 | 0.9797 | 1.5829 | ||
| HCC1143 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 12112.16 | uM | 13.0250 | 4.55930 | 0.3445 | 0.2984 | 0.8653 | 0.1600 | 0.9739 | 1.7073 | ||
| HCC70 | TNBC | Basal A | Ibandronate | FDPS | 12400.143 | uM | 78.39170 | 75.29820 | 0.0680 | 0.0702 | 3.7592 | 0.2421 | 0.9652 | 1.3002 | ||
| HCC3153 | TNBC | Basal A | Ibandronate | FDPS | 10937.143 | uM | 76.74170 | 86.08140 | -0.1089 | -0.1059 | 1.6725 | 0.2383 | 0.9923 | 1.3133 | ||
| BT-20 | TNBC | Basal A | Torkinib | 15385.211 | uM | 0.00007 | 0.00943 | -0.7410 | -0.9904 | 0.2213 | 1.1960 | 0.990 | 0.7321 | |||
| MDA-MB-453 | TNBC | Luminal | Methylglyoxal | 13647.184 | uM | inf | inf | -0.8749 | -0.8749 | 0.0000 | 0.3852 | 0.4269 | 1.2942 | |||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 10817.15 | uM | inf | 2.06940 | 0.5134 | 0.5168 | 4.9958 | 0.1013 | 0.9788 | 1.3689 | ||
| MDA-MB-453 | TNBC | Luminal | Mebendazole | 12964.174 | uM | 0.21977 | 0.29241 | -0.4032 | -0.2943 | 1.6205 | 0.5795 | 0.9637 | 0.7885 | |||
| MDA-MB-453 | TNBC | Luminal | Mebendazole | 13562.174 | uM | 0.10597 | 0.12962 | -0.3553 | -0.2507 | 2.0171 | 0.6156 | 0.9838 | 0.7219 | |||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 12365.169 | uM | inf | 2.76580 | 0.7240 | 0.7388 | 5.0000 | 0.0520 | 0.9488 | 2.1831 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 9386.026 | uM | 1.40510 | 14.81740 | -0.8956 | -0.9802 | 0.4607 | 0.8841 | 0.9611 | 1.5583 | ||
| MDA-MB-415 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7897.016 | uM | 32.84980 | 48.58170 | -0.9480 | -1.0000 | 2.8076 | 0.2266 | 0.9871 | 0.7300 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9254.124 | uM | 26.98710 | 1000.00000 | 0.1010 | -0.7823 | 0.2607 | 0.2991 | 0.7092 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9258.026 | uM | 0.44087 | 35.50130 | -1.0000 | -1.0000 | 0.2503 | 0.8247 | 0.7494 | 0.5632 | ||
| MDA-MB-175-VII | HR+ | Luminal | Ibandronate | FDPS | 12126.143 | uM | 83.13350 | 138.95970 | -0.8487 | -0.8720 | 1.9648 | 0.4595 | 0.9467 | 0.6729 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7813.018 | uM | 67.35460 | 248.74160 | -0.9987 | -1.0000 | 0.8409 | 0.6221 | 0.8654 | 0.8420 | ||
| HCC3153 | TNBC | Basal A | Mebendazole | 13583.174 | uM | 0.16580 | 0.26708 | -0.6804 | -0.5978 | 1.6495 | 0.6918 | 0.9714 | 0.3654 | |||
| SUM225CWN | HER2amp | Basal A | Ribavirin | 15403.211 | uM | inf | inf | 0.4799 | 0.4799 | 0.0000 | 0.2473 | 0.3950 | 0.7553 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 12964.174 | uM | 5.03420 | 8.04630 | -0.9964 | -1.0000 | 2.3427 | 0.2872 | 0.9802 | 0.7885 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 13562.174 | uM | 9.50690 | 8.91340 | 0.1303 | 0.1283 | 4.5978 | 0.0948 | 0.9810 | 0.7219 |