Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MB 157
Unknown
Unknown
 Purvalanol A
CDK1
CDK
7482.067
uM
1.75670
1.74740
 0.1498 0.0132 5.0000 0.4222
0.7450
 1.9350
MB 157
Unknown
Unknown
 NU6102
CDK1/2
CDK
12580.147
uM
15.12290
15.03190
 0.0154 0.0149 4.9987 0.0904
0.9945
 2.2358
MB 157
Unknown
Unknown
 NSC 663284
CDC25
CDC
12580.152
uM
1.98170
2.38630
 -0.7558 -0.7659 5.0000 0.5664
0.9993
 2.2597
MB 157
Unknown
Unknown
 Valproic acid
HDAC
HDAC
12580.143
uM
3111.8610
999.99970
 0.1758 0.3973 1.3940 0.0819
0.7946
 2.2318
MB 157
Unknown
Unknown
 Selumetinib
MEK
MAPK
12580.155
uM
0.26308
0.08392
 0.2460 0.2091 0.4742 0.3920
0.9920
 2.2315
MB 157
Unknown
Unknown
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7482.095
uM
0.45491
0.21241
 0.3008 0.2970 1.1838 0.5367
0.9244
 2.2108
MB 157
Unknown
Unknown
 SB-3CT
MMP2/9
MMP
12580.168
uM
inf
999.49420
 0.9016 0.7834 0.1339 0.0552
0.5863
 2.0973
MB 157
Unknown
Unknown
 TCS PIM-1 1
Pim kinase
PIM
12580.135
uM
inf
150.77040
 0.8333 0.5221 4.9812 -0.0078
0.7813
 2.1782
MB 157
Unknown
Unknown
 TCS 2312
CHK1
CHK
12580.152
uM
0.39369
0.40867
 -0.1760 -0.1026 5.0000 0.3574
0.9921
 2.2597
MB 157
Unknown
Unknown
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7482.067
uM
3.83970
8.99340
 -0.9514 -1.0000 1.2908 0.5341
0.9614
 1.9350
HBL-100
Unknown
Unknown
 Trametinib
MEK
MAPK
7807.036
uM
inf
0.09670
 0.7568 0.7592 0.6422 0.1072
0.8697
 2.0706
HBL-100
Unknown
Unknown
 Vinorelbine
TUBB
TUBB
7807.042
uM
0.00755
0.00930
 -0.7909 -0.3868 2.7529 0.8927
0.9460
 2.0250
HBL-100
Unknown
Unknown
 Trametinib
MEK
MAPK
9226.012
uM
inf
0.03632
 0.8723 0.8653 0.3925 0.0676
0.6610
 2.5039
MB 157
Unknown
Unknown
 Nilotinib
ABL
nRTK
12580.17
uM
inf
inf
 0.8681 0.8681 0.0000 -0.0263
0.5610
 1.9993
MB 157
Unknown
Unknown
 MG-132
Proteasome
Proteasome
12580.17
uM
0.21638
0.29557
 -0.7447 -0.7340 2.8965 0.7295
0.9997
 1.9993
MB 157
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
7482.074
uM
0.06606
0.12226
 -0.9072 -0.9152 1.6901 1.0906
0.9972
 1.7663
MB 157
Unknown
Unknown
 FR180204
ERK1/2
MAPK
12580.166
uM
41.2180
19.53060
 0.4213 0.4065 2.2451 0.0457
0.9696
 1.8686
MB 157
Unknown
Unknown
 MG-132
Proteasome
Proteasome
12580.17
uM
0.21638
0.29557
 -0.7447 -0.7340 2.8965 0.7295
0.9997
 1.9993
MB 157
Unknown
Unknown
 Methotrexate
DHFR
Metabolism
7482.084
uM
0.00739
0.00686
 0.1498 0.1549 5.0000 0.6920
0.9484
 1.8697
MX1
Unknown
Unknown
 Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
14649.189
uM
0.70080
0.92660
 -0.9986 -0.9984 3.9295 0.6674
0.9968
 0.5692
MX1
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
14918.203
uM
0.00872
0.01466
 -0.9994 -0.9980 2.1115 1.3233
0.9984
 0.5296
MB 157
Unknown
Unknown
 Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
7482.084
uM
inf
inf
 1.0106 1.0106 0.0000 -0.0449
-13.5536
 1.8697
MX1
Unknown
Unknown
 Afatinib
EGFR/HER2
ErbB
12220.158
uM
0.17826
0.56481
 -0.9999 -1.0000 0.9526 0.7567
0.9683
 0.4308
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10874.145
uM
0.12033
0.15614
 -0.9820 -0.9785 4.1620 0.8984
0.9993
 0.8505
MX1
Unknown
Unknown
 Glycyl-H-1152
ROCK2
10874.15
uM
0.88473
3.17410
 -0.7532 -1.0000 0.8600 0.4557
0.9604
 0.9133