Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7546.091 | uM | inf | 25.29620 | 0.6366 | 0.4707 | 0.8202 | 0.0468 | 0.9418 | 0.9137 | |
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7545.098 | uM | inf | 0.28442 | 0.4163 | 0.6197 | 0.6883 | 0.1888 | 0.5808 | 1.1555 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 12608.166 | uM | 131.28130 | 123.39570 | 0.7748 | 0.1328 | 4.9834 | 0.0232 | 0.6626 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7544.092 | uM | inf | inf | 0.8657 | 0.8657 | 0.0000 | 0.0626 | 0.0671 | 1.1147 | |
| T47DKBLUC | Unknown | Unknown | NU6102 | CDK1/2 | CDK | 12608.147 | uM | 39.84450 | 90.57230 | 0.2005 | -1.0000 | 1.3378 | 0.1063 | 0.9593 | 1.3009 | |
| T47DKBLUC | Unknown | Unknown | Temsirolimus | MTOR | MTOR | 12608.168 | uM | 27.11690 | 51.12810 | -0.7218 | -1.0000 | 1.7323 | 0.2848 | 0.9094 | 1.0486 | |
| T47DKBLUC | Unknown | Unknown | Nilotinib | ABL | nRTK | 12608.17 | uM | inf | inf | 0.9687 | 0.9687 | 0.0000 | 0.0606 | 0.0000 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 7544.098 | uM | inf | inf | 0.9586 | 0.9586 | 0.0000 | 0.0541 | -0.0405 | 1.2438 | |
| T47DKBLUC | Unknown | Unknown | Imatinib | ABL/KIT/PDGFR | nRTK | 7545.092 | uM | 21.72750 | 30.76630 | -0.9856 | -0.9957 | 3.1501 | 0.4575 | 0.9950 | 0.9794 | |
| T47DKBLUC | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 12608.171 | uM | 59.36460 | 784.13470 | 0.5749 | -1.0000 | 0.4257 | 0.1093 | 0.8147 | 1.0643 | |
| T47DKBLUC | Unknown | Unknown | Imatinib | ABL/KIT/PDGFR | nRTK | 7544.092 | uM | 22.78430 | 32.06150 | -0.9669 | -0.9803 | 3.1776 | 0.4751 | 0.9878 | 1.1147 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 12608.166 | uM | 28.92460 | 48.3580 | 0.3895 | -0.8971 | 1.9994 | 0.0582 | 0.9461 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | Ixabepilone | TUBB | TUBB | 7546.095 | uM | 0.01571 | 1.40280 | -0.9954 | -1.0000 | 0.2446 | 0.6612 | 0.6033 | 0.8399 | |
| T47DKBLUC | Unknown | Unknown | JNK-IN-5A | JNK | JNK | 12608.168 | uM | inf | inf | 0.9658 | 0.9658 | 0.0000 | 0.0146 | 0.0000 | 1.0486 | |
| T47DKBLUC | Unknown | Unknown | Nelfinavir | 13070.174 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0140 | 0.0000 | 0.7993 | |||
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7546.074 | uM | 1.40170 | 3.59650 | -0.9706 | -1.0000 | 1.1659 | 0.5733 | 0.9954 | 0.8465 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7546.074 | uM | 1.40170 | 3.59650 | -0.9706 | -1.0000 | 1.1659 | 0.5733 | 0.9954 | 0.8465 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 12608.17 | uM | inf | 4.16560 | 0.6154 | 0.6143 | 5.0000 | 0.1122 | 0.7923 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Dichloroacetate | PDK | PDK | 13070.176 | uM | inf | inf | 0.7638 | 0.7638 | 0.0000 | 0.0901 | 0.5163 | 0.9664 | |
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7545.092 | uM | inf | inf | 0.9211 | 0.9211 | 0.0000 | -0.0109 | 0.4842 | 0.9794 | |
| T47DKBLUC | Unknown | Unknown | Everolimus | MTOR | MTOR | 12608.164 | uM | 3.22850 | 44.48590 | -0.3473 | -1.0000 | 0.4188 | 0.3159 | 0.8078 | 1.1044 | |
| T47DKBLUC | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 12608.167 | uM | inf | inf | 0.9819 | 0.9819 | 0.0000 | -0.0030 | 0.1862 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 12608.169 | uM | inf | inf | 0.8859 | 0.8859 | 0.0000 | 0.0116 | 0.3497 | 1.2559 | ||
| T47DKBLUC | Unknown | Unknown | IKK16 | IKK | NFKB | 7545.1 | uM | 3.14960 | 3.99390 | -0.9669 | -0.9682 | 4.5357 | 0.4461 | 0.9927 | 1.1396 | |
| T47DKBLUC | Unknown | Unknown | Imatinib | ABL/KIT/PDGFR | nRTK | 7546.091 | uM | 15.51280 | 25.90320 | -0.9892 | -1.0000 | 2.1428 | 0.4938 | 0.9955 | 0.9137 |