Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | 5-FU | TYMS | TYMS | 7872.017 | uM | inf | inf | 1.0126 | 1.0126 | 0.0000 | 0.1656 | 0.1751 | 1.5155 | |
| MCF 10F | NM | - | 5-FU | TYMS | TYMS | 9566.017 | uM | inf | inf | -0.5228 | -0.5228 | 0.0000 | 0.9440 | 0.5049 | 2.1734 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 7487.066 | uM | 3.16780 | 3.58670 | -0.2159 | -0.2180 | 2.9137 | 0.2458 | 0.9890 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 7486.066 | uM | 6.10380 | 6.67550 | -0.2819 | -0.2824 | 5.0000 | 0.1371 | 0.9935 | 1.0443 | |
| MCF 10F | NM | - | AS-252424 | PI3K | PI3K | 12254.165 | uM | inf | 7.11430 | 0.5640 | 0.5638 | 4.9952 | 0.0226 | 0.9503 | 1.6980 | |
| MCF 10F | NM | - | Baicalein | Lipoxygenase | Metabolism | 7486.072 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0295 | -0.4179 | 1.0885 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 14751.203 | uM | 0.00760 | 0.02274 | -0.7561 | -0.6964 | 0.7957 | 1.0581 | 0.9771 | 1.8391 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 14751.203 | uM | 0.00760 | 0.02274 | -0.7561 | -0.6964 | 0.7957 | 1.0581 | 0.9771 | 1.8391 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| MCF 10F | NM | - | Carboplatin | DNA cross-linker | DNA cross-linker | 9566.011 | uM | 50.05840 | 101.28940 | -0.7823 | -0.8360 | 1.3945 | 0.3717 | 0.9990 | 2.3358 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7871.018 | uM | inf | inf | 0.9011 | 0.9011 | 0.0000 | -0.0407 | -0.0154 | 1.1973 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13719.174 | uM | inf | 0.02944 | 0.8637 | 0.8697 | 4.9974 | 0.0852 | 0.6419 | 0.8124 | |
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14607.189 | uM | 0.09589 | 0.20341 | -0.9029 | -0.9017 | 1.3707 | 0.8886 | 0.9922 | 1.3733 | |
| 21MT-1 | HER2amp | - | Nelfinavir | 13719.174 | uM | 10.30820 | 13.49270 | -0.9513 | -1.0000 | 4.0808 | 0.1693 | 0.9959 | 0.8124 | |||
| 21MT-1 | HER2amp | - | Ribavirin | 15382.211 | uM | inf | inf | 0.9683 | 0.9683 | 0.0000 | 0.0416 | 0.0000 | 1.1714 | |||
| 21NT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14783.203 | uM | 3.0610 | 4.70130 | -0.8093 | -0.8292 | 2.2786 | 0.4078 | 0.9883 | 1.8667 | |
| 21NT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14783.203 | uM | 3.0610 | 4.70130 | -0.8093 | -0.8292 | 2.2786 | 0.4078 | 0.9883 | 1.8667 | |
| 21NT | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13575.174 | uM | 25.85920 | 36.60680 | -0.6014 | -0.8791 | 2.9191 | 0.1524 | 0.9863 | 1.5845 | |
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 7872.017 | uM | inf | inf | 1.0147 | 1.0147 | 0.0000 | 0.0576 | 0.1865 | 1.5155 | |
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 9566.026 | uM | 528.70890 | 925.43090 | -0.8038 | -0.8874 | 1.8230 | 0.3767 | 0.9064 | 2.1367 |