Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 9566.132 | uM | inf | inf | 0.8030 | 0.8030 | 0.0000 | 0.1021 | 0.1442 | 2.4013 | ||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7488.016 | uM | inf | inf | 0.7328 | 0.7328 | 0.0000 | 0.0898 | 0.5484 | 1.2238 | ||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7872.016 | uM | 7.35710 | 5.64830 | 0.1459 | 0.2589 | 2.7594 | 0.2512 | 0.8956 | 1.4834 | ||
| MCF 10F | NM | - | 17-AAG | HSP90 | HSP90 | 9566.037 | uM | 0.02204 | 0.02960 | -0.6811 | -0.4104 | 2.0316 | 0.8581 | 0.9734 | 2.3981 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13719.174 | uM | inf | 0.02944 | 0.8637 | 0.8697 | 4.9974 | 0.0852 | 0.6419 | 0.8124 | |
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14607.189 | uM | 0.09589 | 0.20341 | -0.9029 | -0.9017 | 1.3707 | 0.8886 | 0.9922 | 1.3733 | |
| 21MT-1 | HER2amp | - | Nelfinavir | 13719.174 | uM | 10.30820 | 13.49270 | -0.9513 | -1.0000 | 4.0808 | 0.1693 | 0.9959 | 0.8124 | |||
| 21MT-1 | HER2amp | - | Ribavirin | 15382.211 | uM | inf | inf | 0.9683 | 0.9683 | 0.0000 | 0.0416 | 0.0000 | 1.1714 | |||
| 21NT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14783.203 | uM | 3.0610 | 4.70130 | -0.8093 | -0.8292 | 2.2786 | 0.4078 | 0.9883 | 1.8667 | |
| 21NT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14783.203 | uM | 3.0610 | 4.70130 | -0.8093 | -0.8292 | 2.2786 | 0.4078 | 0.9883 | 1.8667 | |
| 21NT | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13575.174 | uM | 25.85920 | 36.60680 | -0.6014 | -0.8791 | 2.9191 | 0.1524 | 0.9863 | 1.5845 | |
| 21NT | HER2amp | - | Mebendazole | 13575.174 | uM | 0.70544 | 0.60467 | 0.2760 | 0.2687 | 5.0000 | 0.2944 | 0.9408 | 1.5845 | |||
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14194.189 | uM | 0.10310 | 0.10891 | -0.3512 | -0.1578 | 5.0000 | 0.6651 | 0.5943 | 2.3616 | |
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14610.189 | uM | 0.09536 | 0.14625 | -0.9556 | -0.9536 | 2.4958 | 0.9558 | 0.9950 | 1.0787 | |
| 21NT | HER2amp | - | Nelfinavir | 13575.174 | uM | 19.74930 | 24.7910 | -0.2090 | -0.6289 | 3.5820 | 0.0991 | 0.9947 | 1.5845 | |||
| 21NT | HER2amp | - | Ribavirin | 15383.211 | uM | inf | inf | 1.0074 | 1.0074 | 0.0000 | 0.0469 | 0.0000 | 1.0341 | |||
| 21PT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14715.203 | uM | 0.01691 | 0.02685 | -0.7771 | -0.7768 | 2.0279 | 1.0962 | 0.9968 | 2.0168 | |
| CAL-148 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15276.203 | uM | 0.04767 | 0.09858 | -0.8960 | -0.9196 | 1.4362 | 1.0010 | 0.9955 | 1.6831 | |
| MCF 10F | NM | - | 5-FU | TYMS | TYMS | 7872.017 | uM | inf | inf | 1.0126 | 1.0126 | 0.0000 | 0.1656 | 0.1751 | 1.5155 | |
| MCF 10F | NM | - | 5-DFUR | TYMS | TYMS | 12254.143 | uM | 63.3380 | 706.87470 | -0.1749 | -0.7057 | 0.3649 | 0.3869 | 0.9817 | 1.4110 |