Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 9860.019 | uM | inf | 0.66920 | 0.6943 | 0.6826 | 1.3958 | 0.1614 | 0.7691 | 1.6927 | |
| SUM229PE | TNBC | - | Baicalein | Lipoxygenase | Metabolism | 11058.072 | uM | inf | 999.9990 | 0.7363 | 0.5109 | 0.1359 | 0.1245 | 0.6645 | 2.3023 | |
| SUM229PE | TNBC | - | Baicalein | Lipoxygenase | Metabolism | 7535.072 | uM | 50.49310 | 39.54220 | 0.3408 | 0.3400 | 4.6606 | 0.0824 | 0.9254 | 1.0923 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7535.074 | uM | 0.75051 | 3.36660 | -0.9254 | -1.0000 | 0.7320 | 0.6555 | 0.9722 | 1.0507 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 15338.203 | uM | 0.00224 | 0.00478 | -0.7351 | -0.7103 | 1.1636 | 1.2624 | 0.9965 | 1.9034 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 15338.203 | uM | 0.00224 | 0.00478 | -0.7351 | -0.7103 | 1.1636 | 1.2624 | 0.9965 | 1.9034 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 13009.177 | uM | 0.02778 | 0.03439 | -0.9703 | -0.9534 | 5.0000 | 1.0656 | 0.9991 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 13062.177 | uM | 0.03738 | 0.04574 | -0.8823 | -0.8489 | 4.9175 | 0.9640 | 0.9994 | 1.7820 | |
| SUM229PE | TNBC | - | CGC-11047 | Polyamine analogue | 9860.125 | uM | 72.45260 | 605.28790 | -0.8188 | -1.0000 | 0.5175 | 0.4253 | 0.9106 | 1.6001 | ||
| SUM229PE | TNBC | - | Chloroquine | 13009.177 | uM | 12.99640 | 13.93620 | -0.2084 | -0.2089 | 5.0000 | 0.2147 | 0.8774 | 1.2366 | |||
| SUM229PE | TNBC | - | Cisplatin | DNA cross-linker | DNA cross-linker | 9860.017 | uM | 5.30820 | 6.87760 | -0.5188 | -0.4096 | 2.3102 | 0.3798 | 0.9912 | 1.7158 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 9860.121 | uM | 7.0970 | 19.66470 | -0.6646 | -1.0000 | 1.0780 | 0.2568 | 0.9930 | 1.7546 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13062.174 | uM | inf | inf | 0.9527 | 0.9527 | 0.0000 | 0.0333 | 0.0263 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13009.174 | uM | 15.01220 | 22.51350 | -0.9124 | -1.0000 | 2.7109 | 0.2119 | 0.9846 | 1.4104 | |
| SUM229PE | TNBC | - | Docetaxel | TUBB | TUBB | 13062.002 | uM | 0.01265 | 0.01189 | 0.0675 | 0.0500 | 1.6910 | 0.4907 | 0.9973 | 1.6470 | |
| SUM229PE | TNBC | - | Docetaxel | TUBB | TUBB | 9860.002 | uM | 0.00390 | 0.00430 | -0.1347 | -0.1014 | 1.9159 | 0.6524 | 0.9980 | 1.5734 | |
| SUM229PE | TNBC | - | Epirubicin | TOP2 | TOP | 9860.017 | uM | 0.25418 | 0.41053 | -0.9694 | -0.4570 | 1.3542 | 0.6519 | 0.8910 | 1.7158 | |
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7536.09 | uM | inf | inf | 0.4561 | 0.4561 | 0.0000 | 0.2955 | 0.4278 | 1.1257 | |
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7537.091 | uM | 28.06160 | 33.68310 | 0.4130 | -0.0340 | 0.3606 | 0.1825 | 0.9730 | 2.0227 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 7535.074 | uM | 0.7680 | 1.77280 | -0.8127 | -0.7914 | 1.1343 | 0.7541 | 0.9949 | 1.0507 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7537.071 | uM | 0.64321 | 3.09880 | -0.8120 | -1.0000 | 0.6987 | 0.5906 | 0.9838 | 1.9607 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7535.092 | uM | 0.57156 | 1.34310 | -0.9514 | -0.8961 | 1.2018 | 0.6138 | 0.9831 | 1.1267 |