Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14233.189 | uM | 0.23986 | 0.55671 | -0.9876 | -0.9894 | 1.2963 | 0.7600 | 0.9937 | 0.3780 | |
| BT-474 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14119.189 | uM | 1.43850 | 2.09160 | -0.5407 | -0.5210 | 1.9072 | 0.4272 | 0.9968 | 1.2143 | |
| MX1 | Unknown | Unknown | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14649.189 | uM | 0.70080 | 0.92660 | -0.9986 | -0.9984 | 3.9295 | 0.6674 | 0.9968 | 0.5692 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 11058.15 | uM | 3.80470 | 1.74960 | 0.2789 | 0.2083 | 0.6935 | 0.2046 | 0.9511 | 2.2684 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10816.15 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3031 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10754.15 | uM | 2.41910 | 3.480 | -0.0159 | -0.1762 | 0.8303 | 0.2555 | 0.9648 | 1.1628 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 11056.15 | uM | inf | 0.46426 | 0.6809 | 0.6831 | 2.5666 | 0.1026 | 0.9909 | 3.0207 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 10520.138 | uM | 2.50290 | 0.69273 | 0.2033 | 0.4113 | 1.3463 | 0.2226 | 0.8598 | 3.3183 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 12365.169 | uM | inf | 0.64004 | 0.6059 | 0.6378 | 3.4420 | 0.1185 | 0.9695 | 2.1831 | |
| ZR75B | HR+ | Luminal | ZM-447439 | AURK | AURK | 11939.16 | uM | inf | 0.38150 | 0.3784 | 0.5796 | 4.9967 | 0.1978 | 0.7753 | 1.6749 | |
| 184A1 | NM | Basal | ZM-447439 | AURK | AURK | 12509.169 | uM | inf | 1.20210 | 0.5422 | 0.5277 | 0.9240 | 0.1592 | 0.9369 | 1.5064 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 11852.16 | uM | 5.49590 | 6.65840 | 0.1000 | -0.0752 | 0.7303 | 0.2739 | 0.8993 | 1.2383 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 12192.16 | uM | 1.27190 | 0.63873 | 0.1767 | 0.2379 | 0.9378 | 0.3421 | 0.9088 | 0.7363 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 12098.16 | uM | 13.38460 | 65.75340 | -0.2414 | -1.0000 | 0.6902 | 0.2552 | 0.8253 | 0.9575 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10937.15 | uM | 72.81410 | 997.6140 | 0.5754 | -0.5774 | 0.2933 | 0.1313 | 0.9014 | 1.3769 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 11938.16 | uM | inf | inf | 0.2260 | 0.2260 | 0.0000 | 0.3323 | 0.5322 | 0.6405 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 10998.15 | uM | inf | 0.4260 | 0.5290 | 0.5770 | 2.1068 | 0.1652 | 0.8990 | 0.8386 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 12269.16 | uM | 29.68990 | 62.01540 | -0.3594 | -1.0000 | 1.4915 | 0.1898 | 0.9050 | 0.6567 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 12319.169 | uM | inf | inf | 0.3374 | 0.3374 | 0.0000 | 0.2734 | 0.4729 | 0.9948 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 11057.15 | uM | inf | 0.43340 | 0.6315 | 0.6227 | 5.0000 | 0.1138 | 0.9875 | 4.0042 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 11851.16 | uM | 26.1590 | 5.3650 | 0.4229 | 0.3228 | 0.6549 | 0.1836 | 0.9224 | 1.1668 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 10939.15 | uM | 20.19260 | 258.04830 | 0.4108 | -1.0000 | 0.4312 | 0.1438 | 0.9441 | 1.6881 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12084.16 | uM | 10.36280 | 49.94910 | -0.3937 | -1.0000 | 0.6985 | 0.2339 | 0.8776 | 1.1178 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10580.138 | uM | inf | inf | 0.1979 | 0.1979 | 0.0000 | 0.3064 | 0.5198 | 0.9584 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12000.169 | uM | 1.98770 | 4.28150 | -0.8539 | -0.9196 | 1.3600 | 0.4011 | 0.9959 | 0.8565 |